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| 1 | 筛状神经上皮性肿瘤(CRINET):具有SMARCB1缺失分子特征的预后好的非横纹肌样肿瘤显示文摘非典型畸胎样/横纹肌样肿瘤(ATRT)是以横纹肌样形态及SMARCB1(INI1)表达缺失为特征的脑肿瘤。筛状神经上皮性肿瘤(CRINETs)为筛状生长模式伴有SMARCB1表达缺失的罕见非横纹肌样脑肿瘤。小的病例系列报道提示CRINETs可能具有相对良好的预后,然而长期预后还不清楚,且CRINET是一个独立的肿瘤还是ATRT的变异亚型仍不明确。 | Johann P D Hovestadt V Thomas C 蔡珊珊 王行富 | 2017 | 临床与实验病理学杂志2017，33，2： | 4 |
| 2 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 3 | Acid‐suppressive therapy is associated with spontaneous bacterial peritonitis in cirrhotic patients: A meta‐analysis显示文摘 | Abhishek Deshpande Vinay Pasupuleti Priyaleela Thota Chaitanya Pant Sulaiman Mapara Sohaib Hassan David D K Rolston Thomas J Sferra Adrian V Hernandez | 2013 | J Gastroenterol Hepatol2013，，2： | 3 |
| 4 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 5 | Post-collisional magmatism in the central East African orogen: The Maevarano suite of north Madagascm显示文摘 | Goodenough K M Thomas R J De Waele B Key R M Schofield D I Bauer W Tucker R D Kafahatelo J M Rabrimanana M Ralison A V Randriamananjma T | 2010 | Lithos2010，116，12： | 1 |
| 6 | Partial Least-squares Methods for Spectral Analyses Relation to Other Quantitative Calibration Methods and the Extraction of Qualitative Information 显示文摘 | Haaland D M Thomas E V | 1988 | Anal Chem1988，60，： | 1 |
| 7 | Improving the nutritive value of full-fat rice bran for broiler chickens using a lipase-basedenzyme preparation显示文摘 | Tan S H Thomas D V Cumden B Je t al | 2000 | Asian Australasian Journal of Animal Sciences2000，13，3： | 1 |
| 8 | A phenyl-thiadiazolyli- dene-amine derivative ejects zinc from retroviral nuc-leo- capsid zinc fingers and inactivates HIV virions 显示文摘 | Thomas V Beata B Wim D | 2012 | Retro- virology2012，95，： | 1 |
| 9 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 10 | Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB显示文摘 | Maus M V Thomas A K Leonard D G | 2002 | Nat Biotechnol2002，20，： | 1 |
| 11 | Age-associated defect in human TLR-1/2 function显示文摘 | van Duin D Mohanty S Thomas V | 2007 | J Immunol2007，178，2： | 1 |
| 12 | Modelling pressure drop in HEPA filters during dynamic filtration 显示文摘 | THOMAS D CONTAL P RENAUDIN V | 1999 | Aerosol Sci1999，30，2： | 1 |
| 13 | Effects of simultane- ous ozone exposme and nitrogen loads on carbohydrate concentrations, biomass and growth of young spruce trees(Picea abies) 显示文摘 | THOMAS V F D BRAUN S FLOCKIGER W | 2005 | Environ- mental Pollution2005，137，3： | 1 |
| 14 | Nanostructured biomaterials for regenerative medicine 显示文摘 | Thomas V Dean D Vohra YK | 2006 | Curr Nanosci2006，2，3： | 1 |
| 15 | Isolated myeloid sarcoma presenting in all four eyelids 显示文摘 | Thomas S A Durairaj V D | 2007 | Ophthal Plast Reconstr Surg2007，23，4： | 1 |
| 16 | Germinal transpositions of the maize element Dissocia-tion from T-DNA loci in tomato显示文摘 | Carroll B J Klimyuk V I Thomas C M Bishop G J HarrisonK Scofield S R Jones J D G | | 0，，： | 1 |
| 17 | Imagequality assessment based on a degradation model显示文摘 | NARANJAN D V THOMAS D K WILSONS S G | 2000 | IEEE Trans Image Proceedings2000，9，4： | 1 |
| 18 | Performance and welfare of broilers as affected by stocking density and zinc bacitracin supplementation显示文摘 | Ravindran V Thomas D | 2006 | Animal Science Journal2006，77，1： | 1 |
| 19 | Circadian genomics of the chick pineal gland in vitro显示文摘 | Karaganis S P Kumar V Beremand P D Bailey M J Thomas T L Cassone V M | 2008 | BMC Genomics2008，9206，： | 1 |
| 20 | Effect of strepzototocin-in-duced diabetes mellitus on release of vasoactive intestinal polypeptidefrom rodent small intestine显示文摘 | Thomas V Nowak M D William W | 1995 | Dig Dis Sci1995，40，47： | 1 |
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