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| 1 | Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED. | ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu | 2003 | Asian Journal of Andrology2003，5，1： | 38 |
| 2 | Molecular and cellular characterization during chondrogenic differentiation of adipose tissue-derived stromal cells in vitro and cartilage formation in vivo显示文摘 | Lin Y Luo E Chen X Liu L Qiao J Yan Z Li Z Tang W Zheng X Tian W | 2006 | 中国生物学文摘2006，20，5： | 31 |
| 3 | Multilineage differentiation of adipose-derived stromal cells from GFP transgenic mice显示文摘 | Lin Y Chen X Yan Z Liu L Tang W Zheng X Li Z Qiao J Li S Tian W | 2006 | 中国生物学文摘2006，20，5： | 16 |
| 4 | Proliferation and pluripotency potential of ectomesenchymal cells derived from first branchial arch显示文摘 | Lin Y Yan Z Liu L Qiao J Jing W Wu L Chert X Li Z Tang W Zheng X Tian W | 2006 | 中国生物学文摘2006，20，5： | 3 |
| 5 | Image enhancement and minutiae matching in fingerprint verification显示文摘 | He Y L Tian J Luo X P | 2003 | Pattem Recognition Letters2003，24，910： | 1 |
| 6 | A neural network for setting target yields显示文摘 | Liu J Goering C E Tian L | 2001 | Transactions of the ASAE2001，44，3： | 1 |
| 7 | Organizational decision support system for effective R&D project selection 显示文摘 | TIAN Q MA J LIANG J RON C W K OU L | 2005 | Decision Support Systems2005，39，3： | 1 |
| 8 | Fabrication and application of nearfield optical fiber probe显示文摘 | Sun J L Xu J H Tian G Y | 2001 | Chinese Physics2001，10，7： | 1 |
| 9 | Active immunogene therapy of cancer with vaccine on the basis of chicken homologous matrix metalloproteinase-2显示文摘 | Su J M Wei Y Q Tian L | 2003 | Cancer Res2003，63，： | 1 |
| 10 | Adv Mater显示文摘 | Liu F Tian J F Bao L H | 2008 | 20(13): 26092008，20，13： | 1 |
| 11 | Artificial gynogenesis and sex determination in half-smooth tongue sole ( Cynoglossus semilaevis) 显示文摘 | Chen S L Tian Y S Yang J F | 2009 | Marine Biotechnology2009，11，2： | 1 |
| 12 | Lipopolysaccharide- activated B ceils down-regulate Thl immunity and prevent autoimmune diabetes in nonobese diabetic mice 显示文摘 | Tian J Zekzer D Hanssen L | 2001 | J Immunol2001，167，2： | 1 |
| 13 | RGD targeting hyaluronic acid coating system for PEI-PBLG polycation gene carriers显示文摘 | Tian H Lin L Chen J | 2011 | J Control Release2011，155，： | 1 |
| 14 | A review of kinetic models for inactivating microorganisms and enzymes by pulsed electric field processing显示文摘 | Huang K Tian H Gai L Wang J | 2012 | Journal of Food Engineering2012，111，2： | 1 |
| 15 | Effect of summer cover crop and residue management on cucumber growth in intensive Chinese production systems: soil nutrients, microbial properties and nematodes 显示文摘 | Tian Y Q Zhang X Y Liu J Gao L H | 2011 | Plant and Soil2011，339，12： | 1 |
| 16 | Electrochemical treatment of graphite anode to enhance power production in microbial fuel cell显示文摘 | TANG X H GUO K TIAN J L DU Z W LI H R | | 0，，： | 1 |
| 17 | Fishery biology of pur-pleback squid,Sthenoteuthis oualaniensis,in the northwest Indian Ocean显示文摘 | Chen X J Liu B L Tian S Q | | 0，，： | 1 |
| 18 | Effect of dietary lipid level on growth, feed utilization and body compo- sition by juvenile grass carp (Ctenopharyngodon idel- la) 显示文摘 | DU Z Y LIU Y J TIAN L X | 2005 | Aquaculture Nutrition2005，11，2： | 1 |
| 19 | Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages显示文摘 | Cao J Han Z Tian L | 2014 | J Transl Mcd2014，12，1： | 1 |
| 20 | Utilization of different raw and pre-gelatinized starch sources by juvenile yellowfin sea- bream Sparus latus 显示文摘 | WU X Y LIU Y J TIAN L X | 2007 | Aquaculture Nutrition2007，13，5： | 1 |
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