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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 3 | Evaluation of bone healing following immediate and delayed dental implant placement显示文摘 | Younis L Taher A Abu - Hassan MI Tin O | 2009 | J Contemp Dent Pract2009，10，4： | 1 |
| 4 | Market emergence and transition:arbitrage,transaction cost and autarky in China grain markets显示文摘 | PARK A TIN H ROZELLE S | 2002 | American Journal of Agricultural Economics2002，84，3： | 1 |
| 5 | Surface properties and foam sta-bility of protein/ surfactantmixtures:theory and exper-iment显示文摘 | MALDONADO -VALDERRAMAJ LANGEVIN D MAR -TIN - MOLINA A | 2007 | Journal of Physical Chemistry C2007，111，6： | 1 |
| 6 | Limita tion of conventional two dimensional radiation therapy planning in nasopharyngeal carcinoma 显示文摘 | WALDRON J TIN M M KELLER A | 2003 | Radiother Oncol2003，68，： | 1 |
| 7 | Limitation of conventional two dimensional radiation therapy planning in nasopharyngeal carcinoma 显示文摘 | Waldron J Tin MM Keller A | 2003 | Radiother Oncol2003，68，2： | 1 |
| 8 | Cine MRI using steady state free precession in the radial long axis orientation is a fast accurate method for obtaining volumetric data of the left ventricle显示文摘 | Bloomer TIN Plein S Radjenovic A | 2001 | J Magn Reson Imaging2001，14，： | 1 |
| 9 | Effect of Ru on the high temperature phase stability of Ni-base single crystal superalloys 显示文摘 | YEH A C TIN S | 2006 | Metallurgical and Materials Transactions A2006，37，： | 1 |
| 10 | Efficacy of vinblastin in central vervous system Langer- hans cell histiocytosis: a nation wide retrospective study 显示文摘 | Ng Wing Tin S Martin -Duverneuil N Idbaih A | 2011 | Orphanet J Rare Dis2011，6，1： | 1 |
| 11 | The effect of ruthenium on the intermediate to high temperature creep response of high refractory content single crystal suepralloy 显示文摘 | HOBBS R A ZHANG L RAE C M F TIN S | 2008 | Materials Science and Engineering A2008，489，： | 1 |
| 12 | Market emergence and transi- tion: arbitrage, transaction cost and autarky in Ch - ina grain markets 显示文摘 | PARK A TIN H ROZELLE S | 2002 | American Journal of Agricultural Economics2002，84，1： | 1 |
| 13 | Non-linear In-plane Buckling of Rationally Restrained Shallow Arches under a Central Con centrated Load显示文摘 | Pi Y L Bradford M A TIN L F | 2008 | International Journal of Non-Linear Me- chanics2008，43，1： | 1 |
| 14 | L imitation of conventional two dimensional radiation therapy planning in nasopharyngeal carcinoma 显示文摘 | Waldron J Tin MM Keller A | 2003 | Radiother Oneo12003，68，2： | 1 |
| 15 | Directional solidification of large superalloy castings with radiation and liquid-metal cooling:a comparative assessment显示文摘 | Elliott A J Tin S Pollock T M | 2004 | Metallurgical and Materials Transactions A2004，35，： | 1 |
| 16 | Nonlinear Analysis and Buckling of Elastically Supported Circular Shallow Arches 显示文摘 | Pi Y L Bradford M A TIN L F | 2007 | International Journal of Solids andStructures2007，44，78： | 1 |
| 17 | A castability model based onelemental solid-liquid partitioning in advanced nickel-base single-crystal superalloys 显示文摘 | HOBBS R A TIN S RAE C M F | 2005 | Metallurgical and Materials Transactions A2005，36，27： | 1 |
| 18 | Determining factors in the success of R&D coopera- tive agreements between firms and research organizations显示文摘 | Mora - Valentin E M Montoro - Sanchez A Guerras - Mar- tin L A | 2004 | Research Policy2004，33，1： | 1 |
| 19 | Practice of sedation and ana- lgesia in German intensive care units:resuhs of a national sur- vey显示文摘 | Mar tin J Parsch A Martin F | 2005 | Crit Care2005，9，2： | 1 |
| 20 | Gu idel ines on the d iagnosis and m anagem ent of acu te pu lm onary em bo-lism:the T ask Force for the D iagnos is andM anagem ent ofAcu te Pu lm onary Embo lism of the Eu ropean S ociety of C ar-d io logy (ESC)显示文摘 | T orb ick iA Perrier A K onstan tin id es S | | 0，，： | 1 |
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