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| 1 | Treatment of functional dyspepsia with sertraline:A double-blind randomized placebo-controlled pilot study显示文摘AIM:To evaluate sertraline,a selective serotonin reuptake inhibitor in the treatment of patients with functional dyspepsia.METHODS:Consecutive tertiary hospital patients with a clinical diagnosis of functional dyspepsia(FD) according to the Rome Ⅱ criteria with a Hong Kong dyspepsia index(HKDI) of greater than 16 were recruited.Patients commenced enrolment prior to the inception of the Rome Ⅲ criteria for functional dyspepsia.All patients were ethnic Chinese,had a normal upper endoscopy and were Helicobacter pylori negative prior to enrolment.Study patients were randomized to receive sertraline 50 mg or placebo daily for 8 wk.HKDI symptom scores,quality of life,hospital anxiety and depression(HAD) scale and global symptom relief were evaluated before,during and after treatment.Adverse effects were monitored during and after treatment.RESULTS:A total of 193 patients were randomized in the intention to treat(ITT),and 150 patients were included in the per protocol(PP) analysis.In both the ITT and PP,there was no difference in the primary outcome of global dyspepsia symptoms between the sertraline and placebo groups at week 8.In the ITT analysis,98 and 95 patients were randomized to the sertraline and placebo groups respectively.A total of 43 patients withdrew from the study(22.3%) by week 8,with 23 of the 24 drop-outs in the sertraline group occurring prior to week 4(95.8%).In contrast,in the placebo arm,11 of 19 patients dropped out by week 4(57.9%).Utilizing the last response carried forward to account for the drop-outs,there were no differences between the sertraline and placebo groups at baseline in terms of the HKDI,HKDI 26.08 ± 6.19 vs 26.70 ± 5.89,P = 0.433;and at week 8,HKDI 22.41 ± 6.36 vs 23.25 ± 7.30,P = 0.352 respectively.In the PP analysis,74 and 76 patients were randomized to the sertraline and placebo groups respectively.At baseline,there were no statistically significant differences between the sertraline and placebo groups,HKDI 25.83 ± 6.313 vs 27.19 ± 5.929 respectively,P = 0.233;however by week 8,patients in the sertraline group demonstrated a statistically significant difference in their Hong Kong Dyspepsia Index compared to placebo,HKDI 20.53 ± 6.917 vs 23.34 ± 7.199,P = 0.02,respectively).There was also no statistically significant difference in overall quality of life measures or the HAD scale related to treatment in either the ITT or PP analysis at week 8.CONCLUSION:This pilot study,the first to examine sertraline,a selective serotonin reuptake inhibitor,for the management of FD,did not find that it was superior to placebo. | Victoria PY Tan Tin K Cheung Wai M Wong Roberta Pang Benjamin CY Wong | 2012 | World Journal of Gastroenterology2012，18，42： | 14 |
| 2 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 3 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 4 | Nickel-based superalloys for advanced turbine engines: Chemistry, microstructure, and properties显示文摘 | POLLOCK T M TIN S | 2006 | Journal of Propulsion and Power2006，22，2： | 1 |
| 5 | The shaft resistance of axially loaded Piles in clay 显示文摘 | Potts D M Mas'tins J P | 1982 | Geotechnique1982，32，4： | 1 |
| 6 | Nickel-based superalloys for advanced turbine engines: Chemistry, microstructure and properties 显示文摘 | Pollock T M Tin S | 2006 | Journal of Propulsion and Power2006，22，2： | 1 |
| 7 | Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft显示文摘 | Tin M M Cho C H Chan K | 2007 | Carcinogenesis2007，28，13： | 1 |
| 8 | Limita tion of conventional two dimensional radiation therapy planning in nasopharyngeal carcinoma 显示文摘 | WALDRON J TIN M M KELLER A | 2003 | Radiother Oncol2003，68，： | 1 |
| 9 | Phase instabilities and carbon additions in single-crystal nickel-base superalloys 显示文摘 | TIN S POLLOCK T M | 2003 | Materials Science and EngineeringA2003，348，： | 1 |
| 10 | A randomized controlled trial to compare steroid with cyclosporine for theopical treatment of oral lichen planus显示文摘 | Yoke PC Tin GB Kim M J | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2006，102，1： | 1 |
| 11 | The need of the family of critical ill neurosurgical patients:A comparison of nurses' and family members' perceptions显示文摘 | Tin M K Peter F Leung K K | 1999 | J Neurosci Nurs1999，31，6： | 1 |
| 12 | The effect of ruthenium on the intermediate to high temperature creep response of high refractory content single crystal suepralloy 显示文摘 | HOBBS R A ZHANG L RAE C M F TIN S | 2008 | Materials Science and Engineering A2008，489，： | 1 |
| 13 | Non-linear In-plane Buckling of Rationally Restrained Shallow Arches under a Central Con centrated Load显示文摘 | Pi Y L Bradford M A TIN L F | 2008 | International Journal of Non-Linear Me- chanics2008，43，1： | 1 |
| 14 | Directional solidification of large superalloy castings with radiation and liquid-metal cooling:a comparative assessment显示文摘 | Elliott A J Tin S Pollock T M | 2004 | Metallurgical and Materials Transactions A2004，35，： | 1 |
| 15 | Effect of Saccharomyces boulardii in the treatment of acute watery diarrhea in Myanmar children:a randomized controlled study显示文摘 | Htwe K Yee KS Tin M | | 0，，02： | 1 |
| 16 | Nonlinear Analysis and Buckling of Elastically Supported Circular Shallow Arches 显示文摘 | Pi Y L Bradford M A TIN L F | 2007 | International Journal of Solids andStructures2007，44，78： | 1 |
| 17 | A castability model based onelemental solid-liquid partitioning in advanced nickel-base single-crystal superalloys 显示文摘 | HOBBS R A TIN S RAE C M F | 2005 | Metallurgical and Materials Transactions A2005，36，27： | 1 |
| 18 | Determining factors in the success of R&D coopera- tive agreements between firms and research organizations显示文摘 | Mora - Valentin E M Montoro - Sanchez A Guerras - Mar- tin L A | 2004 | Research Policy2004，33，1： | 1 |
| 19 | Stress inducible transcription factor chopz' gdd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms显示文摘 | May tin E V Ubeda M LinJ C | 2001 | Exp Cell Res2001，267，2： | 1 |
| 20 | Anterior Chamber Depth and the risk of Primary Angle Closure in 2 East Asian Populations 显示文摘 | Tin A Winifred P David M | 2005 | Arch Ophthalmol2005，123，4： | 1 |
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