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| 1 | Colorectal cancer in patients under 50 years of age:A retrospective analysis of two institutions' experience显示文摘AIM:To investigate the epidemiological characteristics of colorectal cancer(CRC)in patients under 50 years of age across two institutions.METHODS:Records of patients under age 50 years of age who had CRC surgery over a 16 year period were assessed at two institutions.The following documents where reviewed:admission notes,operative notes,and discharge summaries.The main study variables included:age,presenting symptoms,family history,tumor location,operation,stage/differentiation of disease,and post operative complications.Stage of disease was classified according to the American Joint Committee on Cancer TNM staging system:tumor depth;node status;and metastases.RESULTS:CRC was found in 180 patients under age50 years(87 females,93 males;mean age 41.4±6.2years).Young patients accounted for 11.2%of cases during a 6 year period for which the full data set wasavailable.Eight percent had a 1stdegree and 12%a 2nd degree family CRC history.Almost all patients(94%)were symptomatic at diagnosis;common symptoms included:bleeding(59%),obstruction(9%),and abdominal/rectal pain(35%).Evaluation was often delayed and bleeding frequently attributed to hemorrhoids.Advanced stage CRC(Stage 3 or 4)was noted in 53%of patients.Most tumors were distal to the splenic flexure(77%)and 39%involved the rectum.Most patients(95%)had segmental resections;6 patients had subtotal/total colectomy.Poorly differentiated tumors were noted in 12%and mucinous lesions in 19%of patients of which most had Stage 3 or 4 disease.Twenty-two patients(13%)developed recurrence and/or progression of disease to date.Three patients(ages 42,42and 49 years)went on to develop metachronous primary colon cancers within 3 to 4 years of their initial resection.CONCLUSION:CRC was common in young patients with no family history.Young patients with symptoms merit a timely evaluation to avoid presentation with late stage CRC. | Elizabeth A Myers Daniel L Feingold Kenneth A Forde Tracey Arnell Joon Ho Jang Richard L Whelan | 2013 | World Journal of Gastroenterology2013，19，34： | 9 |
| 2 | Lipid dysregulation in hepatitis C virus, and impact of statin therapy upon clinical outcomes显示文摘The hepatitis C virus(HCV) is one of the most common causes of chronic liver disease and the leading indication for liver transplantation worldwide. Every aspect of the HCV life cycle is closely tied to human lipid metabolism. The virus circulates as a lipid-rich particle, utilizing lipoprotein cell receptors to gain entry into the hepatocyte. It has also been shown to upregulate lipid biosynthesis and impair lipid degradation, resulting in significant intracellular lipid accumulation and circulating hypocholesterolemia. Patients with chronic hepatitis C(CHC) are at increased risk of hepatic steatosis, fibrosis, and cardiovascular disease including accelerated atherosclerosis. HMG Co A Reductase inhibitors, or statins, have been shown to play an important role in the modulation of hepatic steatosis and fibrosis, and recent attention has focused upon their potential therapeutic role in CHC. This article reviews the hepatitis C viral life cycle as it impacts host lipoproteins and lipid metabolism. It then describes the pathogenesis of HCV-related hepatic steatosis, hypocholesterolemia and atherosclerosis, and finally describes the promising anti-viral and anti-fibrotic effects of statins, for the treatment of CHC. | Tracey G Simon Adeel A Butt | 2015 | World Journal of Gastroenterology2015，21，27： | 5 |
| 3 | Dissociating pain from its anticipation in the human brain显示文摘 | Tracey I Gati JS | 1999 | Science1999，284，： | 1 |
| 4 | Dynamically vulcanized alloy innerlin- ers显示文摘 | Tracey D S Tsou A H | 2007 | Rubber World2007，236，6： | 1 |
| 5 | Tumor necrosis factor, other cytokines and disease显示文摘 | Tracey K J Cerami A | 1993 | Annu Rev Cell Biol1993，9，： | 1 |
| 6 | Tumor necrosis factor and other cyto- kines and disease 显示文摘 | Tracey KJ Cerami A | 1993 | Annu Rev Cell Biol1993，9，： | 1 |
| 7 | Tumor necrosis factor in the malnutrition (cachexia) of infection and cancer显示文摘 | Tracey K Cerami A | 1992 | Am J Trop Med Hyg1992，47，12： | 1 |
| 8 | Social entrepre- neurship: A critique and future directions显示文摘 | Dacin M T Dacin P A Tracey P | 2011 | Or- ganization Science2011，22，5： | 1 |
| 9 | Elevatedlevels of acute phase proteins and plasminogen activator inhibitor-1 predict the develppment of type 2 diabetes:the insulin resistance atherosclerosis study显示文摘 | Festa A D Agostion R Tracey R P | 2002 | Diabetes2002，51，4： | 1 |
| 10 | Metabolic responses to cachectin/TNF显示文摘 | Tracey K Cerami A | 1990 | Ann New York Acade Sci1990，587，： | 1 |
| 11 | Manuf acturing technology and strategy formulation :keys to enhanc- ing competitiveness and improving performance 显示文摘 | Michael Tracey Mark A Vonderembse Jeen-Su Lim | 1999 | Journal of Operator Theory1999，，： | 1 |
| 12 | MicroRNA- 34a is a potent tumor suppressor molecule in vivo in neuroblastoma 显示文摘 | Tivnan A Tracey L Buckley PG | 2011 | BMC Cancer2011，11，： | 1 |
| 13 | Tumor necrosis factor:a pleiotropic cytokine and therapeutic target显示文摘 | Tracey K J Cerami A | 1994 | Annual review of medicine1994，45，： | 1 |
| 14 | Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease 显示文摘 | Hong Ye Tracey A R | 2010 | Biochemistry2010，49，24： | 1 |
| 15 | Cachectin/tumor necrosis factor and other cytokines in infectious disease显示文摘 | Tracey K Cerami A | 1989 | Cur Opin Immunol1989，1，3： | 1 |
| 16 | Persistent poststroke hypergly- cemia is independently associated with infarct expansion and worse clinical outcome 显示文摘 | Tracey A Mark Baird Parsons W | 2003 | Stroke2003，34，： | 1 |
| 17 | Advanced glyccaylafion end products quenchnitric oxide and mediate defective endothelium-dependent vasodilation in experimental diabetes 显示文摘 | Bucala R Tracey K J Cerami A | 1991 | J Clin Invest1991，87，2： | 1 |
| 18 | Cachectin/tumournecrosis factor显示文摘 | Vlassara H Cerami A | 1989 | Lancet1989，8647，1： | 1 |
| 19 | A root's ability to retain K+ correlates with salt tolerance in wheat显示文摘 | TRACEY A C BETTS S A REMI CHALMANDRIER | 2008 | Journal of Experimental Botany2008，59，10： | 1 |
| 20 | Advanced glycation end products quench nitrite oxide and mediate defectibe endothelium-dependent vasodilation in experimental diabetes显示文摘 | Bucala R Tracey K J Cerami A | 1991 | Clin Invest1991，87，： | 1 |
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