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| 1 | Cancer epigenetics: linking basic biology to clinical medicine显示文摘癌症进化根本,阶段被 epigenetic 畸形以及基因改变驾驶。epigenetic 控制事件的 Dysregulation 可以导致 DNA methylation 和染色质配置的反常模式,哪个是到癌症的致病的批评贡献者。这些 epigenetic 畸形被在他们的单个部件之间的多重蛋白质建筑群和相互影响包括 DNA methylation 机械放并且坚持说, histone 修饰词,特别地 polycomb (PcG ) 蛋白质,和染色质改变蛋白质。在染色体宽的技术的最近的进展表明了这些 dysregulated epigenetic 部件的参与看起来广泛。而且,作为为癌症的一个驱动力有关像茎的房间 subpopulations 在在癌症和概念的 epigenetic 畸形之间有一个成长连接。新兴的数据建议对正常胚胎、成年的干细胞固有的 epigenetic 风景的方面可以帮助促进在长期的发炎或积累的反应的氧种类的压力下面,恶意的 subpopulations 的进化。最后,理解在癌症的所有类型涉及 epigenetic 畸形的开始和维护的分子的机制为翻译目的有大潜力。这为 epigenetic biomarker 开发已经是明显的,并且为指向的药理学瞄准颠倒癌症特定的 epigenetic 改变。 | Hsing-Chen Tsai Stephen B Baylin | 2011 | Cell Research2011，21，3： | 18 |
| 2 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 3 | Charge control and mobility studies for an AlGaN/GaN high electron mobility transistor显示文摘 | Zhang Y Zhang H B Lin G D Chen P, Yuan Y Z, Tsai K R | | 0，，： | 3 |
| 4 | Computer simulation and stress analysis of helical gears involute teeth显示文摘 | Tsay C B Fong Z H | 1991 | Mech Mach Theory1991，26，2： | 2 |
| 5 | The role of current limitations in Fowler–Nordheim electron emission from carbon films显示文摘 | Cui J B Teo K B K Tsai J T H | 2000 | Appl Phys Lett2000，77，： | 1 |
| 6 | Reversible watermarking: current status and key issues 显示文摘 | FENG J B LIN I C TSAI C S | 2006 | International Journal of Network Security2006，2，3： | 1 |
| 7 | CXC chemo- kine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneu- monia 显示文摘 | Tsai WC Strieter RM Mehrad B | 2000 | Infect Immun2000，68，7： | 1 |
| 8 | Rapid method for separation of bacterial DNA from humic substances in sediments for polymerase chain reaction显示文摘 | Tsai Y L Olson B H 1992 | 1992 | Appl Envir Mivrobiol1992，58，7： | 1 |
| 9 | A case study on ground treatment for a rock tunnel with high groundwater ingression in Taiwan显示文摘 | TSENG D J TSAI B R CHANG L C | 2001 | Tunnelling and Underground Space Technology2001，16，3： | 1 |
| 10 | Amazonian anthrosols sup- port similar microbial communities that differ distinctly from those extant in adjacent,unmodified soils of the same mineralogy显示文摘 | GROSSMAN J ONEILL B E TSAI S M | 2010 | Microbial Ecolo- gy2010，60，： | 1 |
| 11 | Surface conjugation of zwitterionie polymers to inhibit cell adhesion and protein ad- sorption 显示文摘 | CHIEN H W TSAI C C TSAI W B | 2013 | Colloids and Surface B: Biointerfaces2013，107，： | 1 |
| 12 | Fuel/cladding compatibility in U-19Pu-10Zr/HT9-clad fuel at elevated temperature显示文摘 | Cohen A B Tsai H Neimark L A | | 0，，： | 1 |
| 13 | A portable device for real time drowsiness detection using novel active dry electrode system显示文摘 | TSAI P Y HU W KU0 T B | | 0，，06： | 1 |
| 14 | The status of diabetes control in Asia: a cross sectional survey of 24 317 patients with diabetes mellitus in 1998 显示文摘 | CHUANG L M TSAI S T HUANG B Y | 2002 | Diabetic Medicine2002，19，2： | 1 |
| 15 | Growth inhibitors promote differentiation of insulin producing tissue from embryonic stem cells显示文摘 | Hori Y Rulifson I C Tsai B C | 2002 | Proc Natl Acad Sci USA2002，99，16： | 1 |
| 16 | Inhibition of fibrobast proliferation by actinobacillus actinomycetemcomitans显示文摘 | Shenker B J Kushner ME Tsai CC | 1982 | Infect Immun1982，38，： | 1 |
| 17 | Discretization of Dirac delta functions in level set methods 显示文摘 | ENGQUIST B TORNBERG A TSAI R | 2005 | Journal of Computational Physics2005，207，1： | 1 |
| 18 | Efficient inverted solar cells using TiO, nanotube arrays 显示文摘 | YU B Y TSAI A TSAI S P | 2008 | Nanotechnology2008，19，25： | 1 |
| 19 | Template-imprinted nanostructured surface for protein recognition 显示文摘 | Shi H Q Tsai W B Garrison M D | 1999 | Nature1999，398，： | 1 |
| 20 | DC Reactive Sputter Deposition of ZnO:Al Thin Film on Glass显示文摘 | Ting Jyh Ming Tsai B S | 2001 | Materials Chemistry and Physics2001，72，： | 1 |
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