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| 1 | Effect of sunitinib on metastatic gastrointestinal stromal tumor in patients with neurofibromatosis type 1: A case report显示文摘Gastrointestinal stromal tumor (GIST) represents the most common mesenchymal malignancy of the gastrointestinal (GI) tract. In neurofibromatosis (NF), the increased incidence of tumor needs to be considered even in non-symptomatic individuals. Patients with neurofibromatosis NF type 1 have an increased risk of developing GI tumors including rare types such as GIST. We report a case of GIST in a 53-year-old male patient with neurofibromatosis. The patient was diagnosed with NF four years ago and his medical history revealed that he was hospitalized 5 times with a provisional diagnosis of massive lower gastrointestinal bleeding. GIST was diagnosed at explorative laparotomy and the tumor was 21 cm × 13 cm × 7 cm in size. Immunohistochemical examination showed that vimentin, actin and CD117 were positive. Computerized tomography showed peritoneal implants three months later. Imatinib mesylate (600 mg/d) was initiated. However, control computerized tomography revealed liver and omental metastasis. The dosage was elevated to 800 mg/d. Despite high dosage, the progression of the metastatic lesions continued in the liver and omentum. The patient started oral sunitinib malate (Sutent? Pfizer Inc, New York, NY, USA) 50 mg per day for 4 consecutive weeks, followed by 2 wk off per treatment cycle. The metastatic lesions in the liver and omentum were decreased in size after four courses, suggesting that sunitinib is also an effective treatment modality for metastatic GIST in NF patients. | M Emin Kalender Alper Sevinc Ediz Tutar Akif Sirikci Celalettin Camci | 2007 | World Journal of Gastroenterology2007，13，18： | 5 |
| 2 | Therapeutic effect of caffeic acid phenethyl ester on cerulein-induced acute pancreatitis显示文摘AIM: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of ceruleaninduced acute pancreatitis (AP).METHODS: Seventy male Wistar albino rats were divided into seven groups. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 μg/kg) four times at 1-h intervals. CAPE (30 mg/kg) was given by subcutaneous injection at the beginning (CAPE 1 group) and 12 h after the last cerulein injection (CAPE 2 group). Serum amylase, lipase, white blood cell count, and tumor necrosis factor (TNF)-α levels were measured, and pancreatic histopathology was assessed. RESULTS: In the AP group, amylase and lipase levels were found to be elevated and the histopathological evaluation showed massive edema and inflammation of the pancreas, with less fatty necrosis when compared with sham and control groups. Amylase and lipase levels and edema formation decreased signif icantly in the CAPE therapy groups (P < 0001); especially in the CAPE 2 group, edema was improved nearly completely (P = 0001). Inflammation and fatty necrosis were partially recovered by CAPE treatment. The pathologicalresults and amylase level in the placebo groups were similar to those in the AP group. White blood cell count and TNF-α concentration was nearly the same in the CAPE and placebo groups.CONCLUSION: CAPE may be useful agent in treatment of AP but more experimental and clinical studies are needed to support our observation of benef icial effects of CAPE before clinical usage of this agent. | Mehmet Buyukberber M Cemil Savas Cahit Bagci Mehmet Koruk Murat T Gulsen Ediz Tutar Tugba Bilgic Nurdan Ceylan | 2009 | World Journal of Gastroenterology2009，15，41： | 4 |
| 3 | Large eddy simulation of a smooth circular cylinder oscillating normal to a uniform flow 显示文摘 | Tutar M Holdo A E | 2000 | Journal of Fluids Engineering2000，122，： | 1 |
| 4 | Increase in soluble E-selectin level after PTCA and stent implantation : a potential marker of restenosls显示文摘 | Kilickap M Tutar E Aydintug O | 2004 | lnt J Cardiol2004，93，1： | 1 |
| 5 | Computational modeling of airflow patterns and heat transfer prediction through products in a vented box during cooling显示文摘 | Tutar M Erdogdu F Toka B | 2009 | International Journal of Refrigeration2009，32，2： | 1 |
| 6 | Incident cases of heart failure in a community cohort: importance and outcomes of patients with preserved systolic function显示文摘 | Maria Ansari Mark Alexander Ali Tutar Barry M Massie | 2003 | American Heart Journal2003，，1： | 1 |
| 7 | Large eddy simulation of wind flow around parallel buildings with varying configurations显示文摘 | Tutar M Oguz G | 2002 | Fluid Dynamics Research2002，31，12： | 1 |
| 8 | Large eddy simulation of wind flow around parallel buildings with varying configurations显示文摘 | TUTAR M and OGUZ G | 2002 | Fluid Dynamics Research2002，31，12： | 1 |
| 9 | Large eddy simulation of a smooth circular cylinder oscillating normal to a uni- form flow 显示文摘 | Tutar M Holdo A E | 2000 | ASME Journal of Fluids Enginee- ring2000，122，4： | 1 |
| 10 | Numerical simulation for heat transfer and velocity field characteristics of two-phase flow sys- tems in axially rotating horizontal cans显示文摘 | Tutar M Erdogdu F | 2012 | Journal of Food Engineering2012，111，2： | 1 |
| 11 | Large Eddy Simulation of Wind Flow around parallel buildings with varying configuration 显示文摘 | Tutar M Oguz G | 2002 | Fluid Dynamics Research2002，31，56： | 1 |
| 12 | A computational study for axial rotation effects on heat transfer in rotating cans containing hquid water, semi-fluid food system and headspace显示文摘 | Erdogdu F Tutar M | 2012 | International Journal of Heat and Mass Transfer2012，55，1314： | 1 |
| 13 | Large Eddy Simulation of a smooth circular cylinder oscillating normal to a uniform flow 显示文摘 | Tutar M Holdo A E | 2000 | ASME Journal of Fluids Engineering2000，122，： | 1 |
| 14 | Numerical simulation for heat transfer and velocity field characteristics of two-phase flow systems in axially rotating horizontal cans显示文摘 | Tutar M Erdogdu F | 2012 | Journal of Food Engineering2012，111，2： | 1 |
| 15 | Computational modelling of flow around a circular cylinder in sub-critical flow regime with various turbulence models显示文摘 | Tutar M Holdo A E | 2001 | International Journal Numerical Methods in Fluids2001，35，： | 1 |
| 16 | A computational study for axial rotation effects on heat transfer in rotating cans containing liquid water,semi-fluid food system and headspace显示文摘 | Erdogdu F Tutar M | 2012 | International Journal of Heat and Mass Transfer2012，55，1314： | 1 |
| 17 | Heart rate variability during asympomatic periods in children with recurrent neurocardiogenic syncope显示文摘 | Akcaboy M Atalay S Ucar T Tutar E | 2011 | Turk J Pediatr2011，53，1： | 1 |
| 18 | Large eddy simulation of wind flow around parallel buildings with varying configu- ration 显示文摘 | Tutar M Oguz C | 2002 | Fluid Dynamics Research2002，9，： | 1 |
| 19 | Nonvascular complications in pediatric liver recipients:multidetector computed tomography evaluation显示文摘 | Tutar N Coskun M Cevik B | 2006 | Transplant Proc2006，38，2： | 1 |
| 20 | Red blood cell distri- bution and survival in patients with chronic obstructive pulmonary disease显示文摘 | Seyhan E C zgtll M A Tutar N | 2013 | COPD2013，10，4： | 1 |
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