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| 1 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 2 | The hepatocyte growth factor/ Met pathway in development,tumorigenesis,and Bcell differentiation显示文摘 | van der Voort R Taher TE Derksen PW | 2000 | Adv Cancer Res2000，79，1： | 1 |
| 3 | Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met显示文摘 | VOORT R TAHER T I WIELENGA V M | 1999 | J Biol Chem1999，274，10： | 1 |
| 4 | The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B- cell differentiation 显示文摘 | van der Voort R Taher T E Derksen P W | 2000 | Adv Cancer Res2000，79，： | 1 |
| 5 | Exact solutions for free flexural vibration of Lovy- type rectangular thick plates via third-order shear deformation plate theory 显示文摘 | Hosseini-HashemiS Fadaee M Taher H R D | 2011 | Appl Math Mod2011，35，2： | 1 |
| 6 | An investigation on effects of heat treatment on corrosion properties of Ni-P electroless nano coatings 显示文摘 | TAHER R SAEED R A ARMAN Z | 2010 | Mater Design2010，31，： | 1 |
| 7 | Heparan sulfate- modified CD44 promotes hepatocyte growth factor/scatter factor- induced signal transduction through the receptor tyrosion kinasc c-Met 显示文摘 | Van der Voort R Taher TE Wielenga VJ | 1999 | J Biol Chem1999，274，10： | 1 |
| 8 | Exact acoustical analysis of vibrating rectangular plates with two opposite edges simply supported via Mindlin plate theory显示文摘 | HASHEMI S H KHORSHIDI K TAHER H R D | 2009 | Journal of Sound and Vibration2009，322，45： | 1 |
| 9 | Corrosion resistance en- hancement of Ni-P electroless coatings by incorpora- tion of nano-SiOz particles显示文摘 | TAHER R SAEED R A | 2011 | Materials and Design2011，32，1： | 1 |
| 10 | Derivative spectrophotometric determination of iridium after preconcentration of its 1-(2-pyridylazo)-2-naphthol complex on microcrystalline naphthalene 显示文摘 | TAHER M A PURl S BANSAL R K | 1997 | Talanta1997，45，： | 1 |
| 11 | The hepa- tocyte growth factor/Met pathway in development, tu- morigenesis, and B-cell differentiation显示文摘 | Vander Voort R Taher T E Derksen P W | 2000 | Adv Cancer Res2000，79，： | 1 |
| 12 | Bone disease and skeletal complications in patients with 13 thalassemia major 显示文摘 | Haidar R Musallam KM Taher AT | 2011 | Bone2011，48，： | 1 |
| 13 | Dynamic response of concrete pavements to moving aircraft显示文摘 | Taher M R Zaman M M Alvappillai A | 1990 | Applied Mathematic Modelling1990，14，11： | 1 |
| 14 | The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation 显示文摘 | Van Der Voort R Taher T Derksen P W | 2000 | Advances in Cancer Research2000，79，： | 1 |
| 15 | Amyloid-显示文摘 | Taher N McKenzie C Garrett R | 2014 | J Alzheimers Dis2014，38，： | 1 |
| 16 | Derivative spectrophotometric determination of iridium after preconcentration of its 1-(2-pyridylazo)-2-naphthol complex onmicroerystalline naphthalene显示文摘 | Taher M Ali Bansal S Puri b Puri b R K B K | 1997 | Talanta1997，，45： | 1 |
| 17 | Sinus of valsalva rupture with dissection into the interventricular septum: diagnosis by echocardiography and magnetic resonance imaging显示文摘 | Taher T Singal R Sonnenberg B et ah Images in cardiovascular medicine | 2005 | Circulation2005，111，7： | 1 |
| 18 | 查看详情显示文摘 | Jin M J Taher A Kang H J Choi M Ryoo R | | 0，，： | 1 |
| 19 | Indoleamine,3-dioxygenase-dependent tryptophan metabolites contribute to tolerance induction during allergen immunotherapy in a mouse model显示文摘 | Taher Y A Piavaux B J Gras R | 2008 | J Allergy Clin Immunol2008，121，4： | 1 |
| 20 | The hepatocyte growth factor/Met pathway in development, tumorigenesis, and Bcell differentiation显示文摘 | van der Voort R Taher TE Derksen PW | 2000 | Adv Cancer Res2000，79，1： | 1 |
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