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| 1 | 妊娠期使用拉莫三嗪与其致畸形的风险 | Cunnington M. Tennis P. 李一明 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，8： | 3 |
| 2 | Mechanical activation of spike fosters SARS-CoV-2 viral infection显示文摘The outbreak of SARS-CoV-2(SARS2)has caused a global COVID-19 pandemic.The spike protein of SARS2(SARS2-S)recognizes host receptors,including ACE2,to initiate viral entry in a complex biomechanical environment.Here,we reveal that tensile force,generated by bending of the host cell membrane,strengthens spike recognition of ACE2 and accelerates the detachment of spike’s S1 subunit from the S2 subunit to rapidly prime the viral fusion machinery.Mechanistically,such mechano-activation is fulfilled by force-induced opening and rotation of spike’s receptor-binding domain to prolong the bond lifetime of spike/ACE2 binding,up to 4 times longer than that of SARS-S binding with ACE2 under 10 pN force application,and subsequently by force-accelerated S1/S2 detachment which is up to~103 times faster than that in the no-force condition.Interestingly,the SARS2-S D614G mutant,a more infectious variant,shows 3-time stronger force-dependent ACE2 binding and 35-time faster force-induced S1/S2 detachment.We also reveal that an anti-S1/S2 non-RBD-blocking antibody that was derived from convalescent COVID-19 patients with potent neutralizing capability can reduce S1/S2 detachment by 3×106 times under force.Our study sheds light on the mechano-chemistry of spike activation and on developing a non-RBD-blocking but S1/S2-locking therapeutic strategy to prevent SARS2 invasion. | Wei Hu Yong Zhang Panyu Fei Tongtong Zhang Danmei Yao Yufei Gao Jia Liu Hui Chen Qiao Lu Tenny Mudianto Xinrui Zhang Chuxuan Xiao Yang Ye Qiming Sun Jing Zhang Qi Xie Pei-Hui Wang Jun Wang Zhenhai Li Jizhong Lou Wei Chen | 2021 | Cell Research2021，31，10： | 2 |
| 3 | Additive mixing modulation for public key eneryption based on distributed dynamics显示文摘 | TENNY R TSIMRING L S | 2005 | IEEE Transactions on Circuits and Systems2005，52，3： | 1 |
| 4 | Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics显示文摘 | Mockenhaupt M Messenheimer J Tennis P | 2005 | Neurology2005，64，7： | 1 |
| 5 | Idazoxan treatmant in progressive supranuclear palsy显示文摘 | Ghika J Tennis M Hoffman E | 1991 | Neurology1991，41，7： | 1 |
| 6 | A postmarketing evaluation of the frequency of use and safety of live attenuated influenza vaccineuse in no- nrecommended children younger than 5 years显示文摘 | Tennis P Toback SL Andrews E | 2011 | Vaccine2011，29，31： | 1 |
| 7 | Risk of Stevens-Johnson syndrome and toxic epidermal neerolysis in new users of antiepileptics显示文摘 | Mockenhaupt M Messenheimer J Tennis P | 2005 | Neurology2005，64，7： | 1 |
| 8 | A model for two types of calcium silicate hydrate in the microstructure of Portland cement pastes 显示文摘 | Tennis P D Jennings H M | 2000 | Cement and Concrete Research2000，30，6： | 1 |
| 9 | Additive Mixing Modulation for Public Key Encryption Based on Distributed Dynamics显示文摘 | Tenny R Tsimring L S | 2005 | IEEE Transactions on Circuits and Systems2005，52，3： | 1 |
| 10 | Assessing the distribution of sulfate in Portland cement and clinker and its influence on expansion in mortar显示文摘 | TENNIS P D BHATTACHARJA S KLEMM W A | 1999 | Cem Concr Aggreg1999，21，2： | 1 |
| 11 | Age but not diagnosis is the main predictor of plasmabeta - amyloid levels 显示文摘 | Fukumoto H Tennis M Locascio J J | 2003 | Arch Neurol2003，60，： | 1 |
| 12 | Synovial fibro- blasts spread rheumatoid arthritis to unaffected joints 显示文摘 | Lefevre S Knedla A Tennie C | 2009 | Nat Med2009，15，12： | 1 |
| 13 | Opportunities and Challenges in Using Epidemiologic Methods to Monitor Drug Safety in the Era of Large Automated Health Databases显示文摘 | Elizabeth B Andrews Andrea V Margulis Patricia Tennis | 2014 | Curr Epidemiol Rep2014，1，： | 1 |
| 14 | Sudden unexplained death among subjects with refractory epilepsy显示文摘 | Derby LE Tennis P Jick H | 1996 | Epilepsia1996，37，： | 1 |
| 15 | Age but not diagnosis is main predictor of plasma amyloid β-protein levels 显示文摘 | Fukumoto H Tennis M Locascio JJ | 2003 | Arch Neurol2003，60，7： | 1 |
| 16 | Cohort study of incidence of sudden unexplained death in persons with seizure disorder treated with antiepileptic drugs in Saskatchewan, Canada显示文摘 | Tennis P Cole TB Annegers JF | 1995 | Epilepsia1995，36，： | 1 |
| 17 | Are one or twodangerous? Exposure in toddlers显示文摘 | Tenny J Thomas Denis Pauze Jeffrey N Love | 2008 | The Journal of EmergencyMedicine2008，34，1： | 1 |
| 18 | Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: a record linkage study显示文摘 | Tennis P Stern R S | 1997 | Neurology1997，49，2： | 1 |
| 19 | Age but not diagnosis is the main predictor of plasma amyloid beta- protein levels 显示文摘 | Fukumoto H Tennis M Locascio J J | 2003 | Arch Neurol2003，60，7： | 1 |
| 20 | Cohort study of inci dence of sudden unexplained death in persons with seizure dis order treated with antiepileptic drugs in Saskatchewan, Cana da显示文摘 | Tennis P Cole TB Annegers JF | 1995 | Epilepsia1995，36，1： | 1 |
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