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| 1 | Hepatitis C virus genotypes distribution and transmission risk factors in Luxembourg from 1991 to 2006显示文摘AIM:To analyze the Hepatitis C virus (HCV) genotype distribution and transmission risk factors in a population of unselected patients in Luxembourg. METHODS:Epidemiological information (gender, age and transmission risks) were collected from 802 patients newly diagnosed for hepatitis C and living in Luxembourg, among whom 228 patients referred from prison. Genotyping using 5'noncoding (5'NC) sequencing was performed. We compared categorical data using the Fisher's exact F-test and odds ratios (OR) were calculated for evaluating association of HCV genotype and risk factors. RESULTS:The sex ratio was predominantly male (2.2) and individuals aged less than 40 years represented 49.6% of the population. Genotype 1 was predominant (53.4%) followed by genotype 3 (33%). Among risk factors, intravenous drug usage (IVDU) was the most frequently reported (71.4%) followed by medical-related transmission (17.6%) including haemophilia, transfusion recipients and other nosocomial reasons. Genotype 3 was significantly associated to IVDU (OR = 4.84, P < 0.0001) whereas genotype 1 was significantly associated with a medical procedure (OR = 2.42, P < 0.001). The HCV genotype distribution from inmate patients differed significantly from the rest of the population (Chi-square test with four degrees of freedom, P < 0.0001) with a higher frequency of genotype 3 (46.5% vs 27.5%) and a lower frequency of genotype 1 and 4 (44.7% vs 56.8% and 5.3% vs 9.6%, respectively). IVDU was nearly exclusively reported as a risk factor in prison. CONCLUSION:We report the first description of the HCV genotype distribution in Luxembourg. The repartition is similar to other European countries, with one of the highest European prevalence rates of genotype 3 (33%). Since serology screening became available in 1991, IVDU remains the most common way of HCV transmission in Luxembourg. | Francois Roman Karin Hawotte Daniel Struck Anne-Marie Ternes Jean-Yves Servais Vic Arendt Patrick Hoffman Robert Hemmer Thérèse Staub Carole Seguin-Devaux Jean-Claude Schmit | 2008 | World Journal of Gastroenterology2008，14，8： | 3 |
| 2 | Determination of anti- biotics in different water compartments via liquid chromatography electrospray tandem mass spectrometry 显示文摘 | Hirsch R Ternes T A Haberer K | 1998 | Journal of Chromatography A1998，815，： | 1 |
| 3 | A compact power-efficient 3V CMOS rail-to-rail input/output operational amplifier for VLSI cell libraries显示文摘 | Tern J P Eschauzier R G H | 1994 | IEEE Journal of Solid-State Circuits1994，29，12： | 1 |
| 4 | Occurrence of an- tibiotics in the aquatic environment 显示文摘 | Hirsch R Ternes T Haberer K | 1999 | Sci Total Envi- ron1999，225，1： | 1 |
| 5 | Occurrence of antibiotics in the aquatic environment 显示文摘 | Hirsch R Ternes T Haberer K | 1999 | Science of the Total Environment1999，225，12： | 1 |
| 6 | A sensitive method for the determination of iodine containing diagnostic agents in aqueous matrices using LC-electruspray-tandem-MS detection显示文摘 | Hirsch R Ternes T A Lindart A | 2000 | Fresenius Journal of Analytical Chemistry2000，366，8： | 1 |
| 7 | Occurrence of antibiotics in the aquatic environment显示文摘 | HIRSCH R TERNES T HABERER K | 1999 | Science of Total Environment1999，225，12： | 1 |
| 8 | Determination of antibiotics in different water compartments via liquid chromatography-electrospray tandem mass spectrometry显示文摘 | HIRSCH R TERNES T A HABERER K | 1998 | J Chromatogr A1998，815，： | 1 |
| 9 | Occurrence of antibiotics in the aquatic environment显示文摘 | Hirsch R Ternes T Haberer K | 1999 | Sci Total Environ1999，225，： | 1 |
| 10 | Occurrence of antibiotics in the aquatic environment 显示文摘 | Hirsch R Ternes T Haberer K | 1999 | Science of the Total Environment1999，225，12： | 1 |
| 11 | Occurrence of antibiotics in the aquatic environment 显示文摘 | Hirsch R Ternes T Haberer K | 1999 | Science of the Total Environment1999，255，12： | 1 |
| 12 | Occurrence of\santibiotics in the aquatic environment显示文摘 | Hirsch R Ternes T Haberer K | 1999 | Science of\sthe Total Environment1999，225，12： | 1 |
| 13 | Occurrence of antibiotics in the aquatic environment显示文摘 | Hirsch R Ternes T Haberer K | 1999 | Sci Total Environ1999，225，： | 1 |
| 14 | Occurrence of antibiotics in the aquatic environment 显示文摘 | HIRSCH R TERNES T HABERER K | 1999 | Sci Total Environ1999，225，1： | 1 |
| 15 | Occurrence of antibiotics in the aquatic environment显示文摘 | Hirsch R Ternes T A Haberer K | 1999 | Science of the Total Environment1999，225，： | 1 |
| 16 | Determination of antibiotics in different water compartments via liquid chromatography electrospray tandem mass spectrometry显示文摘 | Hirsch R Ternes T A Haberera K | 1998 | J Chromatogr A1998，815，： | 1 |
| 17 | Polar drug residues in sewage and natural waters in the state of Rio de Janeiro,Brazil显示文摘 | Stumpf M Ternes T A Wilken R D | 1999 | The Science of The Total Environment1999，225，12： | 1 |
| 18 | Determination of antibiotics in different water compartments via liquid chromatography - electrospray tandem mass spectrometry 显示文摘 | HIRSCH R TERNES Th A HABERER K | 1998 | Journal of Chromatography A1998，815，2： | 1 |
| 19 | Interactionof the Cas6 riboendonuclease with CRISPR RNAs: recognition and cleavage 显示文摘 | WANG R PREAMPLUME G TERNS M P | 2011 | Structure2011，19，2： | 1 |
| 20 | Occurrence of antibiotics in the aquatic environment 显示文摘 | HIRSCH R TERNES Th HABERER K | 1999 | Science of the Total Environment1999，225，1： | 1 |
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