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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | 闪速加热导致以地震速率滑动的地壳岩石摩擦强度降低显示文摘地震期间断层的抗滑阻力是地震物理学中的一个关键未知数。实验室中慢滑速率下岩石的摩擦系数为0.6~0.8,与地壳内高应力测量结果一致。我们的研究结果表明,在很高的、地震滑移速率下,地壳硅酸盐岩石摩擦系数的明显降低缘于微观粗糙接触体的强烈'闪速'加热以及由此引起的抗剪强度的衰减。由闪速加热产生的摩擦系数值可以解释沿某些活断层———如圣安德烈斯断层———实测热流异常的缺失。而由闪速加热导致的近乎纯粹的速度弱化摩擦则可以解释地震破裂是如何以自愈合滑动脉冲模式传播的。 | David L Goldsby Terry E Tullis 左玉玲(译) 郑需要(校) | 2011 | 国际地震动态2011，，12： | 5 |
| 3 | Immunoreactivity of CD45,a protein phosphotyrosine phosphatase,in Alzheimer' s disease 显示文摘 | Masliah E Mallory M Hansen L Alford M Albright T Terry R | 1991 | Acta Neuropathol( Berl )1991，83，1： | 2 |
| 4 | Interactions among age, adiposity, bodyweight, lifestyle factors and sex steroid hormones in healthy Singaporean Chinese men显示文摘瞄准:为了在年龄,生活方式因素,人体测量的参数,百分比身体脂肪和类固醇之中检验相互关系,在 531 个健康新加坡人中国人的荷尔蒙参数在 29 和 72 岁之间变老。方法:各种各样的生活方式参数通过调查,和睾丸激素被确定(T) , estradiol (E2 ) , dehydroepi 雄甾酮硫酸盐(DHEAS ) 和性别荷尔蒙绑定血球素(SHBG ) 用确定的方法被测量。人体测量的参数镇定、计算,并且百分比身体脂肪(Siri ) 用 DEXA 扫描仪被测量。结果:SHBG, DHEAS, bioavailable-T (Bio-T ) , E2, Siri, Ht, W/H, W/Ht 和工作应力独立地与年龄被相关。多使用变量分析并且好久调整,吸烟并且另外的相关因素,锻练并且白酒消费在雄激素层次和身体作文上有积极影响。然而,黑色和绿茶消费在身体作文上并且与 E2 和免费 Estradiol 索引(FEI ) 的高水平与否定效果被联系。有更短的睡觉持续时间的人与夜里的睡觉的 6 h 或更多作为与那些相比有显著地更低的 T 层次。更高的 T 层次与脂肪过多的底层和脂肪过多的另外的索引被联系,而更高的 E2 层次与脂肪过多的高水平有关。有更高的 DHEAS 的人比有低 DHEAS 层次的那些显著地更高、重。结论:学习在 gonadal/adrenal 和新陈代谢的分隔空间之中显示出靠近的相互作用,与是的年龄在他们的相互作用的一个关键决定因素。生活方式因素象锻练那样,吸烟,睡觉并且酒精和茶消费可能显著地在在人决定健康的地位起作用。 | Victor H. H. Goh Terry Y. Y. Tong Helen E E Mok Baharudin Said | 2007 | Asian Journal of Andrology2007，9，5： | 2 |
| 5 | Biology of somatotrpin in growth and lactation of domestic animals 显示文摘 | Etherton T D Terry D Bauman D E | 1998 | Physio Rev1998，78，： | 1 |
| 6 | Cadmium tolerance and accumulation in Indian mustard is enhanced by overexpressing- glutamylcysteine synthetase显示文摘 | ZHU Y PILON-SMITS E A H TERRY N | 1999 | Plant Physiol1999，121，4： | 1 |
| 7 | Imaging perinatal brain injury in premature infants显示文摘 | Jeffrey J Terrie E | 2004 | Semin Perinatol2004，28，6： | 1 |
| 8 | Factors affecting incidence reporting by registered nurse:the relationship of perceptions of environ-ment for reporting errors,knowledge of the nursing practice act,and demographics on intent to report errors显示文摘 | Terry T Jason E | | 0，，06： | 1 |
| 9 | Physical basis of cognitive alterations in Alzheimer's disease:synapse loss is the major correlate of cognitive impairment显示文摘 | Terry RD Masliah E Salmon DP | 1991 | Ann Neurol1991，30，： | 1 |
| 10 | Management of Obstructive Sleep Apnea by Continuous Positive Airway Pressure 显示文摘 | Terri E Weaver AS | 2009 | Oral and Maxillo- facial Surgery Clinics of North America2009，4，： | 1 |
| 11 | Minimally invasive thyroidectomy:basic and advanced techniques显示文摘 | Terris DJ Gourin CG Chin E | 2006 | Laryngoscope2006，116，3： | 1 |
| 12 | Transforming growth factor-beta1 (TGF-β1) and TGF-β1 receptors in normal,cirrhotic,and neoplastic human livers显示文摘 | Bedossa P Peltier E Terris B | 1995 | Hepatology1995，21，3： | 1 |
| 13 | Programma- ble imaging: towards a flexible camera显示文摘 | Shree K Nayar Vlad Branzoi Terry E Boult | 2006 | International Journal of Computer Vision2006，78，1： | 1 |
| 14 | Clinical implementation of endoscopic Thyroideetomy in selected patients显示文摘 | Terris DJ Chin E | 2006 | Laryngosco pe2006，，： | 1 |
| 15 | The physcomitrella genome reveals evolutionary insights into the conquest of land by plants 显示文摘 | Rensing S A Lang D Zimmer A D Terry A Salamov A Shapiro H Nishiyama T Perroud P F Lindquist E A Kamisugi Y | 2008 | Science2008，319，5859： | 1 |
| 16 | Gas chromatography olfactometry of dairy products 显示文摘 | Jane E F Terry E A | 1998 | Dairy Journal1998，8，3： | 1 |
| 17 | Immunohistochemical quantific-tion of the synapse-related protein synaptophysin in Alzheimer's disease显示文摘 | Masliah E Terry RD DeTeresa R | 1989 | Neurosci Lett1989，103，2： | 1 |
| 18 | Lube Oil Processing--Conclusion:Catalytic Hydroprocessing a Good Alternative to Solvent Processing 显示文摘 | Terry E Helton Thpmas F Degnan Jr | 1998 | Oil & Gas Journal1998，96，29： | 1 |
| 19 | Random systematic versus directed ultrasound guided transrectal core biopsies of the prostate显示文摘 | Hodge K K McNeal J E Terris M K | 1989 | J Urol1989，142，1： | 1 |
| 20 | High resolution pattern replication utilizing siloxane-modified acrylate networks stamps 显示文摘 | BEST M E MCCLELLAND G TERRIS B D | 2001 | Polymer Preprints2001，42，1： | 1 |
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