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| 1 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 2 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 3 | Stent-angioplasty of intracranial vertebral and basilar artery stenoses in symptomatic patients 显示文摘 | Weber W Mayer TE Henkes H | 2005 | Eur J Radiol2005，55，2： | 1 |
| 4 | Necrotizing sarcoid granulomatosis: computed tomography and pathologic findings显示文摘 | Niimi H Hartman TE Muller NL | 1995 | J Comput Assist Tomogr1995，19，： | 1 |
| 5 | High-resolution CT of the temporal bone in dysplasia of the auricle and external auditory canal显示文摘 | Mayer TE Brueckmann H Siegert R | 1997 | AJNR Am J Neuroradiol1997，18，1： | 1 |
| 6 | Phase Ⅲ trial comparing supportive care alone with supportive care with oral to-potecan in patients with relapsed small cell lung cancer 显示文摘 | O'Brien ME Ciuleanu TE Tsekov H | 2006 | J Clin Oncol2006，24，： | 1 |
| 7 | Risk factors for 30-daymortality after resection of lung cancer and prediction of theirmagnitude显示文摘 | Strand TE Rostad H Damhuis RA | 2007 | Thorax2007，62，11： | 1 |
| 8 | Should monitoring of Vancomycin he delayed?A case of likely nephrotoxieity occasioned by morbid obesityand minimal monitoring显示文摘 | Jones TE Vasilef H Hewton C | 2012 | BrJ Clin Pharmacol2012，74，6： | 1 |
| 9 | Effect of genetic variants of the heart fatty acid-binding protein gene on intramuscular fat and performan-ce traits in pigs显示文摘 | A J van Erp F L Hardem F J Verburg T H Meuwissen J HVeerkamp and M F te Pas | | 0，，04： | 1 |
| 10 | Improved tech- niques for lower bounds for odd perfect numbors显示文摘 | Brent R P Cohen G L te Riele H J J | 1991 | Math Comput1991，196，57： | 1 |
| 11 | Phase Ⅲ trial comparing supportive care alone with supportive care with oral topotecan in patients with relapsed small-cell lung cancer显示文摘 | O'Brien ME Ciuleanu TE Tsekov H | 2006 | J Clin Oncol2006，24，34： | 1 |
| 12 | Depressive symptoms and history of depression predict rehabilitation efficiency in stroke patients 显示文摘 | Gillen R Tennen H McKee TE | 2001 | Arch Phys Med Rehabil2001，82，： | 1 |
| 13 | Adaptive chanhes in early and late blind: A Fmri Study of braille reading显示文摘 | Burton H Snyder AZ Conturo TE | 2002 | J Neurophysiol2002，87，： | 1 |
| 14 | Evidence based selection of housekeeping genes显示文摘 | de Jonge H J Fehrmann R S de Bont E S Hofstra R M Gerbens F Kamps W A de Vries E G van der Zee A G te Meerman G J ter Elst A | | 0，，： | 1 |
| 15 | Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane显示文摘 | te Welscher YM ten Napel HH Balague MM Souza CM Rieaman H de Kruijff B et ol | 2008 | J Biol Chem2008，283，10： | 1 |
| 16 | Progressions of alcohol,cigarette,and marijuana use in adolescence显示文摘 | Duncan SC Duncan TE Hop s H | 1998 | J Behav Med1998，21，： | 1 |
| 17 | Burst abdomen and incisionalhemia:a prospective study of 1129 major laparotomies显示文摘 | Bucknall TE Cox PJ Ellis H | 1982 | BMJ1982，284，6320： | 1 |
| 18 | Instability of the thermohaline ocean circulation on interdecadal timescales显示文摘 | Te RAA L A DIJKSTRA H A | 2002 | Journal of Physical Oceanography2002，32，1： | 1 |
| 19 | Phase Ⅲ trial comparing supportive carealone with supportive carewith oral topotecan in patients with relapsed small-cell lung cancer显示文摘 | O'Brien ME Ciuleanu TE Tsekov H | 2006 | J Clin Oncol2006，24，34： | 1 |
| 20 | Phase Ⅲ trial comparing supportive care alone with supportive care with oral topotecan in patients with relapsed small-cell lung cancer显示文摘 | O'Brien ME Ciuleanu TE Tsekov H | 2006 | J Clin Oncol2006，24，34： | 1 |
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