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| 1 | mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan显示文摘AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis stage.METHODS: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) level.RESULTS: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P < 0.04). When analyzing mi RNA expression in relation to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P < 0.05). ALT levels displayed a positive correlation with mi R-21(P < 0.04). Negative correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P < 0.05), and in the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune liver diseases(P < 0.03). The results also revealed a strong correlation between fibrosis stage and LS values(P < 0.01) when etiology of fibrosis was not taken into account.CONCLUSION: Reduced expression of mi R-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies. | Tünde Halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai | 2015 | World Journal of Gastroenterology2015，21，25： | 11 |
| 2 | Clinical significance of lymphadenectomy in patients with gastric cancer显示文摘Approximately thirty percent of patients with gastric cancer undergo an avoidable lymph node dissection with a higher rate of postoperative complication. Comparing the D1 and D2 dissections,it was found that there is a significant difference in morbidity,favoured D1 dissection without any difference in overall survival. Subgroup analysis of patients with T3 tumor shows a survival difference favoring D2 lymphadenectomy,and there is a better gastric cancer-related death and non-statistically significant improvement of survival for node-positive disease in patients with D2 dissection. However,the extended lymphadenectomy could improve stage-specific survival owing to the stage migration phenomenon. The deployment of centralization and application of national guidelines could improve the surgical outcomes. The Japanese and European guidelines enclose the D2 lymphadenectomy as the gold standard in R0 resection. In the individualized,stageadapted gastric cancer surgery the Maruyama computer program(MCP) can estimate lymph node involvement preoperatively with high accuracy and in addition the Maruyama Index less than 5 has a better impact on survival,than D-level guided surgery. For these reasons,the preoperative application of MCP is recommended routinely,with an aim to perform 'low Maruyama Index surgery'. The sentinel lymph node biopsy(SNB) may decrease the number of redundant lymphadenectomy intraoperatively with a high detection rate(93.7%) and an accuracy of 92%. More accurate stage-adapted surgery could be performed using the MCP and SNB in parallel fashion in gastric cancer. | dezso tóth jános plósz miklós torok | 2016 | World Journal of Gastrointestinal Oncology2016，8，2： | 8 |
| 3 | 沥青自修复微胶囊研究进展显示文摘微胶囊技术在世界上已应用于多个领域,包括医药、食品和化工等,具有广阔的应用前景。将微胶囊引入到沥青材料自修复中,可提高沥青材料的自修复能力并在裂缝产生初期即可自我修复,延长路面使用寿命。与传统的裂缝修补方法相比,微胶囊自修复技术具有节能减排、降低养护成本和防止微裂缝扩展至宏观裂缝等优势。然而,沥青自修复微胶囊技术仍处于初步探索阶段,将微米级微胶囊应用于沥青材料自修复领域还存在着微胶囊强度控制范围不够明确,微胶囊破裂理论尚不成熟,且微胶囊制备工艺参数设计尚不统一等问题。因此,研究者们除研究制备工艺的影响外,还主要从选择合适的制备工艺影响参数和微胶囊的结构与性能方面不断尝试,并取得了丰硕的成果。随着制备工艺的不断成熟和影响参数的不断优化,经原位聚合法制备的微胶囊结构致密、性能优良。目前对掺微胶囊的沥青材料自修复的研究仍存在对沥青材料自修复提升效果的评价方法和评价指标尚不统一等问题。掺微胶囊的沥青材料自修复效果主要通过不同的指标来体现,包括延度、复数模量、拉伸强度、试件的载荷和沥青混合料的疲劳寿命等。其中,还对掺微胶囊的沥青混合料进行了路用性能研究。通过不同的评价指标表明,微胶囊显著提升了沥青材料的自修复效果;掺微胶囊的沥青混合料的水稳定性和高温稳定性略有下降,低温抗裂性下降较大,但仍满足规范要求。为总结沥青自修复微胶囊的研究进展,本文对比分析了多种自修复微胶囊制备方法的优势和特点,解析了影响微胶囊质量的主要因素(芯壁比、反应温度、终点pH值、乳化转速、酸化时间),总结了微胶囊的结构与性能的表征方法,介绍了掺微胶囊沥青材料自修复性能的评价方法与提升效果,阐述了微胶囊对沥青混合料路用性能的影响,探讨了借助分子动力学手段研究掺微胶囊的沥青材料自修复行为理论的可行性并展望了其未来发展前景,以期为微米级微胶囊的应用与发展提供参考。 | 何亮 黄胡端 Wim Van den bergh Tóth Csaba 高杰 Karol Kowalski Jan Valentin | 2020 | 材料导报2020，34，15： | 7 |
| 4 | Diagnosis of focal liver lesions with deep learning-based multichannel analysis of hepatocyte-specific contrast-enhanced magnetic resonance imaging显示文摘BACKGROUND The nature of input data is an essential factor when training neural networks.Research concerning magnetic resonance imaging(MRI)-based diagnosis of liver tumors using deep learning has been rapidly advancing.Still,evidence to support the utilization of multi-dimensional and multi-parametric image data is lacking.Due to higher information content,three-dimensional input should presumably result in higher classification precision.Also,the differentiation between focal liver lesions(FLLs)can only be plausible with simultaneous analysis of multisequence MRI images.AIM To compare diagnostic efficiency of two-dimensional(2D)and three-dimensional(3D)-densely connected convolutional neural networks(DenseNet)for FLLs on multi-sequence MRI.METHODS We retrospectively collected T2-weighted,gadoxetate disodium-enhanced arterial phase,portal venous phase,and hepatobiliary phase MRI scans from patients with focal nodular hyperplasia(FNH),hepatocellular carcinomas(HCC)or liver metastases(MET).Our search identified 71 FNH,69 HCC and 76 MET.After volume registration,the same three most representative axial slices from all sequences were combined into four-channel images to train the 2D-DenseNet264 network.Identical bounding boxes were selected on all scans and stacked into 4D volumes to train the 3D-DenseNet264 model.The test set consisted of 10-10-10 tumors.The performance of the models was compared using area under the receiver operating characteristic curve(AUROC),specificity,sensitivity,positive predictive values(PPV),negative predictive values(NPV),and f1 scores.RESULTS The average AUC value of the 2D model(0.98)was slightly higher than that of the 3D model(0.94).Mean PPV,sensitivity,NPV,specificity and f1 scores(0.94,0.93,0.97,0.97,and 0.93)of the 2D model were also superior to metrics of the 3D model(0.84,0.83,0.92,0.92,and 0.83).The classification metrics of FNH were 0.91,1.00,1.00,0.95,and 0.95 using the 2D and 0.90,0.90,0.95,0.95,and 0.90 using the 3D models.The 2D and 3D networks'performance in the diagnosis of HCC were 1.00,0.80,0.91,1.00,and 0.89 and 0.88,0.70,0.86,0.95,and 0.78,respectively;while the evaluation of MET lesions resulted in 0.91,1.00,1.00,0.95,and 0.95 and 0.75,0.90,0.94,0.85,and 0.82 using the 2D and 3D networks,respectively.CONCLUSION Both 2D and 3D-DenseNets can differentiate FNH,HCC and MET with good accuracy when trained on hepatocyte-specific contrast-enhanced multi-sequence MRI volumes. | Róbert Stollmayer Bettina K Budai Ambrus Tóth IldikóKalina Erika Hartmann Péter Szoldán Viktor Bérczi Pál Maurovich-Horvat Pál N Kaposi | 2021 | World Journal of Gastroenterology2021，27，35： | 6 |
| 5 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 6 | Comparison of different lymph node staging systems in prognosis of gastric cancer:a bi-institutional study from Hungary显示文摘Objective: The Union for International Cancer Control(UICC) Node(N) classification is the most common used staging method for the prognosis of gastric cancer. It demands adequate, at least 16 lymph nodes(LNs) to be dissected; therefore different staging systems were invented.Methods: Between March 2005 and March 2010, 164 patients were evaluated at the Department of General Surgery in the Kenézy Gyula Hospital and at the Department of General, Thoracic and Vascular Surgery in the Kaposi Mór Hospital. The 6th, 7th and 8th UICC N-staging systems, the number of examined LNs, the number of harvested negative LNs, the metastatic lymph node ratio(MLR) and the log odds of positive LNs(LODDS) were determined to measure their 5-year survival rates and to compare them to each other.Results: The overall 5-year survival rate for all patients was 55.5% with a median overall survival time of 102 months. The tumor stage, gender, UICC N-stages, MLR and the LODDS were significant prognostic factors for the 5-year survival with univariate analysis. The 6th UICC N-stage did not follow the adequate risk in comparing N2 vs. N0 and N3 vs. N0 with multivariate investigation. Comparison of performances of the residual N classifications proved that the LODDS system was first in the prediction of prognosis during the evaluation of all patients and in cases with less than 16 harvested LNs. The MLR gave the best prognostic prediction when adequate(more than or equal to 16) lymphadenectomy was performed.Conclusions: We suggest the application of LODDS system routinely in western patients and the usage of MLR classification in cases with extended lymphadenectomy. | dezso tóth adrienn bíró zsolt varga miklós torok péterárkosy | 2017 | Chinese Journal of Cancer Research2017，29，4： | 4 |
| 7 | Microscopic colitis: A retrospective study of clinical presentation in 53 patients显示文摘AIM: To evaluate the relationship between symptoms and microscopic colitis (MC) subtypes: to test whether collagenous colitis (CC) and/or lymphocytic colitis (LC)might be related to both constipation and diarrhea.METHODS: A cohort of patients with independently confirmed typical histopathological changes was investigated. Fifty-three patients with histologically proved MC (46 with CC, 7 with LC) were included. The existence of diarrhea or constipation and the co-existence of autoimmune diseases were also investigated and all data were retrospectively analyzed.RESULTS: Twenty-three (43.39%) of MC patients had chronic constipation (20 in CC, 3 in LC patients). Twentyfour(45.28%) of MC patients had autoimmune disease and the diagnosis of autoimmune disease was always prior to MC. Sjogren's syndrome was associated only with the constipation subgroup.CONCLUSION: The Janus face of MC resembles the subgroups of irritable bowel syndrome. The co-existence of autoimmune diseases and MC is confirmed in both the constipation and diarrhea subgroups. | Zsolt Barta Gabriella Mekkel István Csíp(o|') László Tóth Szabolcs Szakáll Gábor G.Szabó Gyula Bakó Gyula Szegedi Margit Zeher | 2005 | World Journal of Gastroenterology2005，11，9： | 3 |
| 8 | Relationship between diabetes mellitus and cataract in Hungary显示文摘AIM:To examine the coexistence of diabetes mellitus(DM)and cataract in Hungary.The effects of DM on the cataract surgical results were also in the focus of analysis.METHODS:Statistical data analysis of the results of the Rapid Assessment of Avoidable Blindness with Diabetic Retinopathy(RAAB+DR)module conducted in Hungary in 2015.This cross-sectional,population-based,national survey included 3523 people aged 50 years and over.Participants of the survey were examined on-site.Visual acuity,main cause for visual impairment(using direct and indirect ophthalmoscopes),in case of best corrected visual acuity(BCVA)≤0.5 and blood glucose level(random test with glucometer)were examined.RESULTS:The prevalence of cataract was 23.4%,and DM was 20.0%.The occurrence of cataract steadily increased with age.Among the examined participants with DM,the prevalence of cataract was significantly(P=0.012)higher(+35%)than that in non-diabetic subjects(29.5%vs 21.8%).Following aging(OR=15.2%,P<0.001),DM proved to be the most independent influencing risk factor(OR=49.9%,P<0.001).The presence of DM was neither an influencing factor for complications of cataract surgery,nor for postoperative visual acuity.CONCLUSION:DM appears to be one of the main risk factors for developing cataract.Other risk factors,such as age,sex and environment also play an influencing role.Diabetes does not seem to affect the occurrence of cataract surgical complications. | Anita Pék Dorottya Szabó Gábor LászlóSándor Gábor Tóth András Papp Zoltán Zsolt Nagy Hans Limburg János Németh | 2020 | International Journal of Ophthalmology(English edition)2020，13，5： | 2 |
| 9 | 显示文摘 | Péter Antal Torok Gabriella Tóth Géza | 1998 | Journal of Chromatography A1998，797，： | 2 |
| 10 | Drying of suspensions and solutions on inert particle surface in mechanically spouted bed dryer显示文摘To eliminate some disadvantages of the conventional spouted bed dryers the mechanically spouted bed (MSB) system was developed. This dryer type is convenient to use inert particles providing an increased surface area for drying of materials of high-moisture content and heat sensitive materials. On three different drying tasks are demonstrated the experimental optimization of process parameters to obtain products of demanded quality. The main object was at drying of AlO(OH) suspension to preserve the particle size under 2.5 m and to obtain product with a moisture content of about 0.05 kg/kg (d.b.). For this reason a very thin particle coating and intensive abrasion had to be assured. At drying of tomato concentrates the thermoplasticity makes the process very difficult. To jump over the deliquescent and sticky state developed at the critical temperature-moisture content values a very short drying time (8-10 s) must be provided. The third task was to form powder-like product from bovine serum albumin (BSA) solution having very low solid content (2-4%). The selected process parameters given in this paper resulted in a mean particle size of less than 20 m while the soluble preserved protein content was higher than 90%. | Elisabeth Pallai-Varsányi Judit Tóth János Gyenis | 2007 | China Particuology2007，5，5： | 2 |
| 11 | Pulse cyclophosphamide therapy for inflammatory bowel disease显示文摘AIM:To assess the efficacy of intravenous cyclophos-phamide pulse therapy for refractory inflammatory boweldisease(IBD).METHODS:We included in our cohort eight patientswith(moderate/severe)steroid refractory IBD(4 withulcerative colitis and 4 with Crohn's disease).They allreceived 6 cycles of intravenous cyclophosphamide(800mg)per month.RESULTS:Patients entered into remission after the sec-ond/third cyclophosphamide pulse.Disease activity de-creased.There were no side effects and toxicity.All thepatients went into long lasting remission.All Crohn's diseasepatients and 3 of 4 ulcerative colitis patients achievedcomplete remission.One patient with ulcerative colitisshowed an impressive clinical response but did not enterinto remission.For the maintenance,patients with Crohn'sdisease were treated with methotrexate(15 mg/wk)andpatients with ulcerative colitis were treated with azathio-prine(2.5 mg/kg body weight/d).CONCLUSION:Remission was maintained in all pa-tients for 6 mo on the average.The drug was well toler-ated.These findings suggest that aggressive immuno-suppressive therapy may be useful in some refractorypatients and further controlled study should be consid-ered in order to fully evaluate this type of treatment as apotential therapy for IBD. | Zsolt Barta László Tóth Margit Zeher | 2006 | World Journal of Gastroenterology2006，12，8： | 2 |
| 12 | Gain-of-Function Mutations Associated with Hereditary Pancreatitis Enhance Autoactivation of Human Cationic Trypsinogen显示文摘 | Miklós Sahin-Tóth Miklós Tóth | 2000 | Biochemical and Biophysical Research Communications2000，，2： | 2 |
| 13 | The evolution of microstructure in a laser clad TiB-Ti composite coating 显示文摘 | KOOI B J PEI Y T DE HOSSON J Th M | 2003 | Acta Mater2003，51，2： | 2 |
| 14 | Peptide aggregation and pore formation in a lipid bilayer:a combined coarse-grained and all atom molecular dynamics study显示文摘 | Th(o)gersen L Schi(o)tt B Vosegaard T | | 0，，09： | 1 |
| 15 | Functionally Graded Materials Produced by Laser Cladding显示文摘 | Y T pei J TH M DE hosson | 2000 | Functionally Graded Materials2000，，48： | 1 |
| 16 | Epithelial cells from human fallopian tube in culture显示文摘 | Henriksen T Tanbo T Abyholn Th | 1990 | Human Reprod1990，，5： | 1 |
| 17 | Assessment of baseline hemodynamic parameters within infarct progression areas in acute stroke patients using perfusion-weighted MRI显示文摘 | Ritzenthaler T Cho TH Wiart M | | 0，，： | 1 |
| 18 | Value of sentinel lymphnode mapping using a blue dye-only method in gastric cancer: a single-center experience from North-East Hungary显示文摘 | Tóth D1 Kincses Z Plósz J | 2011 | Gastric Cancer2011，14，4： | 1 |
| 19 | Expression of Xanthophyllo-myces dendrorhous cytochrome-P450 hydroxylase and reductase in Mucor circinelloides显示文摘 | Cserneticsá Tóth E Farkas A | 2014 | World Journal of Microbiology and Biotechnology2014，31，2： | 1 |
| 20 | p62/AQATM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy显示文摘 | PANKIV S CLAUSEN TH LUMARK T | 2007 | J Biol Chem2007，282，24： | 1 |
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