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| 1 | Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry显示文摘Background In a three-month report from the CGA-TAVI registry, we found the Multidimensional Prognostic Index (MPI) and Short Physical Performance Battery (SPPB) to be of value for predicting short-term outcomes in elderly patients undergoing transcatheter aortic valve implantation (TAVI). In the present analysis, we examined the association of these tools with outcomes up to one year post-TAVI. Methods CGA-TAVI is an international, observational registry of geriatric patients undergoing TAVI. Patients were assessed using the MPI and SPPB. Efficacy of baseline values and any postoperative change for predicting outcome were established using logistic regression. Kaplan- Meier analysis was carried out for each comprehensive geriatric assessment tool, with survival stratified by risk category. Results One year after TAVI, 14.1% of patients deceased, while 17.4% met the combined endpoint of death and/or non-fatal stroke, and 37.7% the combined endpoint of death and/or hospitalisation and/or non-fatal stroke. A high-risk MPI score was associated with an increased risk of all-cause mortality (aOR = 36.13, 95% CI: 2.77–470.78, P = 0.006) and death and/or non-fatal stroke (aOR = 10.10, 95% CI: 1.48–68.75, P = 0.018). No significant associations were found between a high-risk SPPB score and mortality or two main combined endpoints. In contrast to a worsening SPPB, an aggravating MPI score at three months post-TAVI was associated with an increased risk of death and/or non-fatal stoke at one year (aOR = 95.16, 95% CI: 3.41–2657.01). Conclusions The MPI showed value for predicting the likelihood of death and a combination of death and/or non-fatal stroke by one year after TAVI in elderly patients. | Martijn S.van Mourik Nathalie van der Velde Giulio Mannarino Marie-Pierre Thibodeau Jean-Bernard Masson Gennaro Santoro Jan Baan Sofie Jansen Jana Kurucova Martin Thoenes Cornelia Deutsch ANDreas W.Schoenenberger ANDrea Ungar Peter Bramlage M Marije Vis | 2019 | Journal of Geriatric Cardiology2019，16，6： | 3 |
| 2 | Fak/Src signaling in human intestinal epithelial cell survival and anoikis:differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways显示文摘 | Bouchard V Demers M J Thibodeau S Laquerre V Fujita N Tsuruo T | | 0，，： | 1 |
| 3 | Histologie characteriza- tion of regenerated tissues in canal space after the revitalization/ revascularization procedure of immature dog teeth with apical periodontitis显示文摘 | Wang X Thibodeau B Trope M | 2010 | J Endod2010，36，1： | 1 |
| 4 | Histologic characteriza- tion of regenerated tissues in canal space after the revitalization/ revascularization procedure of immature dog teeth with apical periodontitis 显示文摘 | Wang X Thibodeau B Trope M | 2010 | J Endod2010，36，1： | 1 |
| 5 | Pulp revascular- ization of immature dog teeth with apical periodontitis 显示文摘 | Thibodeau B Teixeira F Yamauchi M | 2007 | J En- dod2007，33，6： | 1 |
| 6 | Cystic fibrosis:recent structural insights显示文摘 | Dorwart M Thibodeau P Thomas P | 2004 | J Cyst Fibros2004，，32： | 1 |
| 7 | Pulp revascularization of a necrotic infected immature permanent tooth: case report and review of the literature显示文摘 | Thibodeau B Trope M | 2012 | Pediatric dentistry2012，29，1： | 1 |
| 8 | Histologic characterization of regenerated tissues in canal space after the revitalization revascularization procedure of immature dog teeth with apical periodontitis显示文摘 | Wang X Thibodeau B Trope M | 2010 | J Endod2010，36，1： | 1 |
| 9 | Cellular and molecular mechanisms regulating silica-induced adhesion molecule expression in mice显示文摘 | HUBBARD A K THIBODEAU M GIARDINA C | 2001 | J Environ Pathol Toxicol Oncol2001，，： | 1 |
| 10 | Validity and reliability of simple nutrition screening tools adapted to the elderly population in healtheare facilities 显示文摘 | Laporte M Villalon L Thibodeau J | 2001 | J Nutr Health Aging2001，5，4： | 1 |
| 11 | Five days of emotion:an experience sampling study of undergraduate student procrastination显示文摘 | Pychyl TA Lee J M Thibodeau R | | 0，，05： | 1 |
| 12 | Histologic characterization of regenerated tissues in canal space after the revitalization/revascularization procedure of immature dog teeth with apical periodontitis显示文摘 | Wang X Thibodeau B Trope M Lin LM Huang GT | 2010 | Journal of endodontics2010，36，1： | 1 |
| 13 | What constitutes spinal instability显示文摘 | Panjabi M M Thibodeau L L Crisco J J | 1988 | Clin Neurosurg1988，34，： | 1 |
| 14 | Microsatellite Instability in Colorectal Cancer:Different Mutator Phenotypes and the Principal Involvement of hMLH1显示文摘 | Thibodeau S N French A J Cunningham J M | 1998 | Cancer Res1998，58，8： | 1 |
| 15 | Histological character- ization of regenerated tissues in canal space after the revital- ization/revascularization procedure of immature dog teeth with apical periodontitis显示文摘 | Wang X Thibodeau B Trope M | 2010 | J Endod2010，36，1： | 1 |
| 16 | Incorporation of total stress changes into the groundwater model SUTRA 显示文摘 | Reeves H W Thibodeau P M Underwood R G | 2000 | Ground Water2000，38，1： | 1 |
| 17 | Intestinal epithelial cancer cell anoikis resistance: EGFR mediated sustained activation of Src over- rides Fak-dependent signaling to MEK/Erk and/orPI3-K/Akt-1 显示文摘 | Demers M J Thibodeau S Noel D | 2009 | J Cell Biochem2009，107，4： | 1 |
| 18 | Pulp revascularization of a necrotic infected immature permanent tooth: case report and review of the literature显示文摘 | Thibodeau B Trope M | 2007 | PediatrDent2007，29，1： | 1 |
| 19 | Pul revascularization of immature dog teeth with apica periodontitis显示文摘 | Thibodeau B Teixeira F Yamauchi M | | 0，，06： | 1 |
| 20 | Pulp revas- cularization of immature dog teeth with apical periodontitis 显示文摘 | Thibodeau B Teixeira F Yamauehi M | 2007 | J Endod2007，33，6： | 1 |
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