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| 1 | Magnetic resonance imaging may predict deep remission in patients with perianal fistulizing Crohn's disease显示文摘AIM To evaluate the imaging course of Crohn's disease(CD) patients with perianal fistulas on long-term maintenance anti-tumor necrosis factor(TNF)-α therapy and identify predictors of deep remission.METHODS All patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by magnetic resonance imaging(MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after. Clinical assessment(remission, response and non-response) was based on Present's criteria. Rectoscopic patterns, MRI Van Assche score, and MRI fistula activity signs(T2 signal and contrast enhancement) were collected for the two MR examinations. Fistula healing was defined as the absence of T2 hyperintensity and contrast enhancement on MRI. Deep remission was defined as the association of both clinical remission, absence of anal canal ulcers and healing on MRI. Characteristics and imaging patterns of patients with and without deep remission were compared by univariate and multivariate analyses.RESULTS Forty-nine consecutive patients(31 females and 18 males) were included. They ranged in age from 14-70 years(mean, 33 years). MRI and clinical assessment were performed after a mean period of exposure to anti-TNF-α therapy of 40 ± 3.7 mo. Clinical remission, response and non-response were observed in 53.1%, 20.4%, and 26.5% of patients, respectively. Deep remission was observed in 32.7% of patients. Among the 26 patients in clinical remission, 10 had persisting inflammation of fistulas on MRI(T2 hyperintensity, n = 7; contrast enhancement, n = 10). Univariate analysis showed that deep remission was associated with the absence of rectal involvement and the absence of switch of anti-TNF-α treatment or surgery requirement. Multivariate analysis demonstrated that only the absence of rectal involvement(OR = 4.6; 95%CI: 1.03-20.5) was associated with deep remission.CONCLUSION Deep remission is achieved in approximately one third of patients on maintenance anti-TNF-α therapy. Absence of rectal involvement is predictive of deep remission. | Lucie Thomassin Laura Armengol-Debeir Cloé Charpentier Valerie Bridoux Edith Koning Guillaume Savoye Céline Savoye-Collet | 2017 | World Journal of Gastroenterology2017，23，23： | 5 |
| 2 | Calcitonin gene-related peptide partly protects cultured smooth muscle cells from apotosis induced by an oxidative stress via activation ERK1/2 MAPK 显示文摘 | Schaeffer C Vandroux D Thomassin L | 2003 | Biochem Biophys Acta2003，1643，13： | 1 |
| 3 | Calcitonin generelated peptide partly protects cultured smooth muscle cells from apoptosis induced by an oxidative stress viaactivation of ERK 1 /2 MAP显示文摘 | Sehaeffer C Vandroux D Thomassin L | 2003 | Biochem Biophys Acta2003，1643，123： | 1 |
| 4 | Calcitonin generelated peptide partly protects cultured smooth muscle cells from apoptosis induced by an oxidative stress viaactivation of ERK 1 /2 MAP显示文摘 | Schaeffer C Vandroux D Thomassin L | 2003 | Biochem Biophys Acta2003，1643，123： | 1 |
| 5 | Contribution of nanoclays to the barrier properties of amodel proton exchange mem- brane for fuel cell application显示文摘 | Thomassin J M Pagnoulle C Caldarella G | 2006 | J Membr Sci2006，270，12： | 1 |
| 6 | Polymer/carbon based composites as electromagnetic interference (EMI) shielding materials 显示文摘 | Thomassin J M J6rOme C Pardoen T | 2013 | MaterSciEngR2013，74，7： | 1 |
| 7 | Calcitonin gene-related peptide partly protects cultured smooth muscle cells from apoptosis induced by an oxidative stress via activation of ERK1/2 MAPK显示文摘 | Schaeffer C Vandroux D Thomassin L | 2003 | Biochim Biophys Acta2003，1643，： | 1 |
| 8 | How todifferentiate benign from malignant myometrial tumours using MRimaging显示文摘 | Thomassin -Naggara I Dechoux S Bonneau C | 2013 | Eur Radiol2013，23，8： | 1 |
| 9 | Polymer/Carbon based Composites as Electromagnetic Interference(EMI) Shielding Materials 显示文摘 | Thomassin J M Jrme C Pardoen T | 2013 | Materials Science and Engineering: R: Reports2013，74，7： | 1 |
| 10 | Local DNA demethylation in vertebrates ; how could it be performed and targeted显示文摘 | Kress C Thomassin H Grange T | 2001 | FEBS Letters2001，494，： | 1 |
| 11 | Calcitonin gene-related peptide p artly protects cultured smooth muscle cells from apoptosis induced by an oxidative stress via activation of ERK1/2 MAPK显示文摘 | Schaeffer C Vandroux D Thomassin L | 2003 | Biochim Biophys Acta2003，1643，13： | 1 |
| 12 | Local DNA demethylation in vertebrates: how could it be performed and targeted?显示文摘 | Kress C Thomassin H Grange T | 2001 | FEBS Letters2001，494，： | 1 |
| 13 | Foams of Polycaprolactone/MWNT Nanocomposites for Efficient EMI Reduction显示文摘 | Thomassin JM Pagnoulle C Bednarz L | 2008 | Journal of Materials Chemistry2008，18，： | 1 |
| 14 | Calcitonin gene-related peptide partly protects cultured smooth muscle cells from apoptosis induced by an oxidative stress via activation of ERK1/2 MAPK显示文摘 | Schaeffer C Vandroux D Thomassin L | 2003 | Biochem Biophys Acta2003，1643，13： | 1 |
| 15 | How to differentiate benign from malignant myometrial tumours using mr imaging显示文摘 | Thomassin Naggara I Dechoux S Bonneau C | 2013 | Eur Radiol2013，23，8： | 1 |
| 16 | Calcitonin gene-related peptide partly protects cultured smooth muscle cells from apoptosis induced by an oxidative stress via activation of ERK1/2 MAPK 显示文摘 | Schaeffer C Vandroux D Thomassin L | 2003 | Bicehim Biophys Acta2003，1643，： | 1 |
| 17 | A novel cyclic hexapeptide as chiral selector: application for HPLC separation of a series of dansyl amino and arylalkanoic acids显示文摘 | Andre C Thomassin M Umrayamib A Ismaili L Refouvelet B Guillaume Y-C | 2007 | Talanta2007，71，： | 1 |
| 18 | Calcitonin gene-related peptide partly protects cultured smooth muscle cells from apotosis induced by an oxidative stress via activation ERK1/2 MAPK显示文摘 | Schaeffer C Vandroux D Thomassin L | 2003 | Biochirn Biophys Acta2003，1643，13： | 1 |
| 19 | 显示文摘 | Thomassin J-M Pagnoulle C Caldarella G | 2005 | polymer2005，46，11： | 1 |
| 20 | 显示文摘 | Thomassin J M Pagnoulle C Bizzari D | 2006 | Solid State Ionics2006，177，： | 1 |
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