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| 1 | 生物素——抗结核药物新研究方向(英文)显示文摘耐药菌的出现对全球公共卫生构成了巨大的挑战,结核分枝杆菌(TB)是结核病的病原菌,是临床上最重要的病原体之一。新抗生素的研发用以治疗耐药性结核病已成为临床及公共卫生管理亟待解决的重要问题。生物素(维生素B7)在结核杆菌的代谢途径如脂肪酸合成和三羧酸循环中发挥重要作用,通过生物素蛋白连接酶连接活性辅助因子而被激活。生物素蛋白连接酶及其相关生物合成通路是微生物合成生物素过程中必不可或缺的关键分子,因而有可能成为新的药物靶点。遗传研究表明,结核杆菌需要由菌体进行生物素的全程合成,因此,生物素合成酶在在结核杆菌代谢过程中起着至关重要的作用,引起了抗结核药物研究者的高度重视。本文论述了结核杆菌生物素合成通路,并重点分析了生物素合成过程中可能成为药物靶点的关键酶,旨在为结核病的治疗提供新思路,具有重要的临床意义。 | THOMPSON Andrew P STERNICKI Louise M WEGENER Kate L 陆伟 竺丽梅 BOOKER Grant W POLYAK Steven W 李燕 | 2016 | 江苏预防医学2016，27，3： | 4 |
| 2 | Endoscopic ultrasound-guided celiac plexus neurolysis using a reverse phase polymer显示文摘AIM:To assess the feasibility of endoscopic ultrasound(EUS)guided celiac plexus neurolysis(CPN) using a poloxamer. METHODS:In this prospective evaluation,six Yorkshire pigs underwent EUS-guided CPN.Three received an injection of 10 mL of 0.25%Lidocaine plus methylene blue(group 1) and three received an injection of 10 mL of 0.25%Lidocaine plus blue colored poloxamer(PS137-25)(group 2) .Necropsy was performed immediately after the animals were sacrificed.The abdominal and pelvic cavities were examined for the presence of methylene blue and the blue colored poloxamer.RESULTS:EUS-guided CPN was successfully performed in all 6 pigs without immediate complication.Methylene blue was identified throughout the peritoneal and retroperitoneal cavity in group 1.The blue colored poloxamer was found in the retroperitoneal cavity immediately adjacent to the aorta,in the exact location of the celiac plexus in group 2.CONCLUSION:EUS-guided CPN using a reverse phase polymer in a non-survival porcine model was technically feasible.The presence of a poloxamer gel at the site of the celiac plexus at necropsy indicates a precise delivery of the neurolytic agent. | Keith L Obstein Fernanda P Martins Gloria Fernández-Esparrach Christopher C Thompson | 2010 | World Journal of Gastroenterology2010，16，6： | 3 |
| 3 | Centrifuge modeling of transport processes for pollutants in soils显示文摘 | Arulanandan K Thompson P Y Kutter B L Meegoda N J Muraleetharan K K Yogachandran C | 1988 | Journal of Geotechnical Engineering Division American Society of Civil Engineering1988，，： | 2 |
| 4 | Comparison of transpiration rates among saltcedar, cottonwood and willow trees by sap flow and canopy temperature methods显示文摘 | PAMELA L Nagler EDWARD P Glenn THOMPSON T Lewis | 2003 | Agri and For Meter2003，116，： | 2 |
| 5 | The Demise of the High Fru- ctose Corn Syrup Futures Contract :A Case Study显示文摘 | THOMPSON S GARCIA P WILDMAN L D | 1996 | Futures Markets1996，16，6： | 1 |
| 6 | Radiosurgery for hemangiomas of the cavernous sinus and orbit: technical case report 显示文摘 | THOMPSON T P LUNSFORD L D FLICKINGER J C | 2000 | Neurosurgery2000，47，3： | 1 |
| 7 | A transmission electron microscopy study of hard anodic oxide layers on AlSi(Cu) alloys 显示文摘 | FRATILA-APACHINTEI L E TICHELAAR F D THOMPSON G E TERRYN H SKELDON P DUSZCZYK J | 2004 | Electrochimica Acta2004，49，19： | 1 |
| 8 | Phase-transfer-catalyzed alkylation of ethyl acetoacetate and diethyl malonate显示文摘 | Thompson D L Reeves P C | 1985 | J Chem Edu1985，62，10： | 1 |
| 9 | Comparison of transpiration rates among sahcedar,cottonwood and wil- low trees by sap flow and canopy temperature methods 显示文摘 | Pamela L N Edward P G Thompson T L | 2003 | Agri and For Meter2003，116，： | 1 |
| 10 | Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility显示文摘 | Thompson C L Fink S P Lutterbaugh J D | 2013 | PLoS One2013，8，64： | 1 |
| 11 | Effect of pH on leaf breakdownin streams and in the laboratory 显示文摘 | THOMPSON P L BARLOCHER F | 1989 | Journal of the North AmericanBenthological Society1989，8，3： | 1 |
| 12 | Primary biliary cirrhosis, hyperlipidemia, and atherosclerotic risk: a systematic review显示文摘 | Sorokin A Brown J L Thompson P D | 2007 | Atherosclerosis2007，194，： | 1 |
| 13 | Formation eagelike intermediates from nonrandom eyelization during acid- catalyzed sol- gel polymerization of tetraethyl orthosilicate 显示文摘 | Ng L V Thompson P Sanehez J | 1995 | Macromolecules1995，28，： | 1 |
| 14 | Defining process design space for monoclonal antibody cell culture显示文摘 | Abu-Absi S F Yang L Thompson P | | 0，，06： | 1 |
| 15 | Yttrium oxynitride glasses:Properties and potential for crystallization to glass-ceramics显示文摘 | HAMPSHIRE S NESTOR E FLYNN R BESSON J L ROUXEL T LEMERCIER H GOURSAT P SEBAI M THOMPSON LIDDELL K | 1994 | Journal of the European Ceramic Society1994，14，3： | 1 |
| 16 | Plasma CD14 decrease monocyte responses to LPS by transferring cell-bound LPS to plasma lipoprotein显示文摘 | Kitchen R L Thompson P A Viriyakosol S | 2001 | J Clin Invest2001，108，3： | 1 |
| 17 | Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome 显示文摘 | GONG M N THOMPSON B T WILLIAMS P L | 2006 | Eur Respir2006，27，4： | 1 |
| 18 | The effect of lowvoltage stimulation under control conditions on the tenderness ofthree muscles in lamb carcass 显示文摘 | Hopkins D L Littlefield P J Thompson J M | 2000 | Asian Australasian Journal ofAnimal Sciences2000，13，： | 1 |
| 19 | 显示文摘 | Thompson K L Armes S P Howse J R | 2010 | Macromole- eules2010，43，10： | 1 |
| 20 | Prolactin and gonadotropin responses in geldings to injections of estradiol benzoate in oil,estradiol benzoate in biodegradable microspheres,and estradiol cypionate显示文摘 | THOMPSON D L MITCHAM P B RUNLES M L | 2008 | J Equine Vet Sci2008，28，4： | 1 |
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