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| 1 | Role of tumor microenvironment in triple-negative breast cancer and its prognostic significance显示文摘Breast cancer has been shown to live in the tumor microenvironment, which consists of not only breast cancer cells themselves but also a significant amount of pathophysiologically altered surrounding stroma and cells. Diverse components of the breast cancer microenvironment, such as suppressive immune cells, re-programmed fibroblast cells, altered extracellular matrix(ECM) and certain soluble factors, synergistically impede an effective anti-tumor response and promote breast cancer progression and metastasis. Among these components, stromal cells in the breast cancer microenvironment are characterized by molecular alterations and aberrant signaling pathways,whereas the ECM features biochemical and biomechanical changes. However, triple-negative breast cancer(TNBC), the most aggressive subtype of this disease that lacks effective therapies available for other subtypes, is considered to feature a unique microenvironment distinct from that of other subtypes, especially compared to Luminal A subtype. Because these changes are now considered to significantly impact breast cancer development and progression, these unique alterations may serve as promising prognostic factors of clinical outcome or potential therapeutic targets for the treatment of TNBC. In this review, we focus on the composition of the TNBC microenvironment, concomitant distinct biological alteration, specific interplay between various cell types and TNBC cells, and the prognostic implications of these findings. | Tianjian Yu Genhong Di | 2017 | Chinese Journal of Cancer Research2017，29，3： | 17 |
| 2 | Impact of coal gangue on the level of main trace elements in the shallow groundwater of a mine reclamation area显示文摘Coal gangue is the most used filling material during reclamation of areas suffering subsidence from min- ing. Main trace element levels (F, As, Hg, and Pb) in shallow groundwater in the reclamation area may be affected by leaching from the gangue. This can has an impact on the application of the water for agricul- tural irrigation or use as drinking water. Therefore, it is of great significance to understand the effect coal gangue has on the shallow groundwater of a reclaimed area. We studied the effect of coal gangue on fluo- rine, arsenic, mercury, and lead levels in the shallow groundwater of a reclamation area by testing the water and the coal gangue. One well near the reclamation area was used as a control well and element levels in water from this well and from the soil next to the well were also measured. The results show that the levels of these elements are increasing in the reclamation area over time. The increase in fluorine, arsenic, mercury, and lead in monitor wells varies from 7.42% to 8.26%, from 7.13% to 7.90%, from 4.85% to 6.48%, and from 4.69% to 6.42%, respectively. Fluorine and arsenic levels are lower in monitor wells than in the control water. The other elements are found in greater concentration than in the control. The Nemerow index also indicates that the shallow groundwater in the reclamation area I is moderately affected by the back-filling coal gangue, while the shallow groundwater in the reclamation area II and III are slightly affected by the back-filling coal gangue. This shallow groundwater could be used for agri- cultural irrigation or for drinking. | Li Wei Chen Longqian Zhou Tianjian Tang Qibao Zhang Ting | 2011 | Mining Science and Technology2011，21，5： | 17 |
| 3 | Ultralight X-type lattice sandwich structure(I):Concept,fabrication and experimental characterization显示文摘A new type of ultra-lightweight metallic lattice structure (named as the X-type structure) is reported. This periodic structure was formed by two groups of staggered struts in the traditional pyramid strurture, and fabricated by folding expanded metal sheet along rows of offset nodes and then brazing the folded structure (as the core) with top and bottom facesheets to form sandwich panels. The out-of-plane compressive and shear properties of the X-type lattice sandwich structure were investigated experimentally and compared to those of the sandwich having a pyramidal truss core. It is found that the formation of the 2-dimensional staggered nodes can effectively make the X-type structure more resistant to inelastic and plastic buckling under both compression and shear loading than the pyramidal lattice truss. Obtained results show that the compressive and shear peak strengths of the X-type lattice structure are about 30% higher than those of the pyramidal lattice truss having the same relative density. | ZHANG QianCheng HAN YunJie CHEN ChangQing LU TianJian | 2009 | Science China(Technological Sciences)2009，52，8： | 14 |
| 4 | Application of Wavelet Analysis toInterference Elimination for Geochemical Hydrocarbon Exploration显示文摘Interference in the data of geochemical hydrocarbon exploration is a large obstacle for anomaly recognition. The multiresolution analysis of wavelet analysis can extract the information at different scales so as to provide a powerful tool for information analysis and processing. Based on the analysis of the geometric nature of hydrocarbon anomalies and background, Mallat wavelet and symmetric border treatment are selected and data pre-processing (logarithm-normalization) is established. This approach provide good results in Shandong and Inner Mongolia, China. It is demonstrated that this approach overcome the disadvantage of backgound variation in the window (interference in window), used in moving average, frame filtering and spatial and scaling modeling methods. | Zhang Liuping Ruan Tianjian Faculty of Earth Resources, China University of Geosciences, Wuhan 430074 | 2000 | Journal of Earth Science2000，19，1： | 7 |
| 5 | Characteristics of annular impinging jets with/without swirling flow by short guide vanes显示文摘Annular jets impinging on a uniformly heated flat plate with or without swirling flow by short guide vanes are experimentally characterized. With the Reynolds number fixed at a relatively low value, the variation of jet flow structures with impinging distance is characterized using the technique of particle image velocimetry (PIV). Correspondingly, the distributions of wall pressure and heat transfer on the plate are measured. At sufficiently large impinging distances, without swirling flow, the obtained flow and wall pressure/heat transfer data are consistent with the classical observation for a conventional annular impinging jet, showing the transition from annular impinging jet flow to single circular impinging jet-like flow. In contrast, no such transition occurs in the presence of flow turning by short guide vanes. At short and intermediate impinging distances, flow turning causes more non-uniform distributions of wall pressure and heat transfer on the target plate and the local heat transfer rates higher than those of the conventional annular jet. This is attributed to the vortical flow structures shed and convected downstream from the short guide vanes. In sharp contrast, at large impinging distances, the larger momentum loss due to flow turning results in lower heat transfer rates on the plate. | YANG HuiQun KIM TongBeum LU TianJian | 2011 | Science China(Technological Sciences)2011，54，3： | 6 |
| 6 | Sound transmission across lightweight all-metallic sandwich panels with corrugated cores显示文摘通过有弄皱的核心的所有金属性的三明治面板的声音的传播用空间泛音方法被调查。三明治面板作为面板到一致地分布式的翻译弹簧和旋转弹簧连接了的二平行被建模,与作为 lumped 质量拿的核心表的团。基于面板结构的频率,一个联合起来的房间模型被开发提供核心的有效翻译、旋转的僵硬。检查模型的有效性,与空气洞,和分析预言学习双面板结构的健全屏蔽性质首先被使用与存在试验性的数据同意很好。模特儿然后被雇用确定在越过有弄皱的核心的三明治面板的健全传播损失(STL ) 上的 facesheet 和核心表之间的健全发生角度和倾斜角度的影响。结果证明倾斜角度在 STL 上有重要效果,由改变倾斜角度避免 STL 剧降是可能的。而且,有弄皱的核心的三明治面板对有小发生角度的声波的屏蔽更合适,这被发现。 | XIN Fengxian LU Tianjian CHEN Changqing | 2009 | Chinese Journal of Acoustics2009，28，3： | 6 |
| 7 | Novel strengthening methods for ultralightweight sandwich structures with periodic lattice cores显示文摘Recent development of ultralightweight lattice-cored sandwiches is reviewed,with focus placed on various novel fabrication methods introduced to strengthen these structures,covering not only research results published in the Science China Series E-Tech Sci,but also those in other domestic and overseas scientific journals. | LU TianJian 1 &ZHANG QianCheng 2 1 MOE Key Laboratory for Strength and Vibration,School of Aerospace,Xi’an Jiaotong University,Xi’an 710049,China 2 State Key Laboratory for Mechanical Behavior of Materials,School of Material Science and Engineering,Xi’an Jiaotong University,Xi’an 710049,China | 2010 | Science China(Technological Sciences)2010，53，3： | 5 |
| 8 | Pyrosequencing-based assessment of bacterial community structure in mine soils affected by mining subsidence显示文摘Based on the 454 pyrosequencing approach, this research evaluated the influence of coal mining subsidence on soil bacterial diversity and community structure in Chinese mining area. In order to characterize the bacterial community comparatively, this study selected a field experiment site with coal-excavated subsidence soils and an adjacent site with non-disturbed agricultural soils, respectively. The dataset comprises 24512 sequences that are affiliated to the 7 phylogenetic groups: proteobacteria, actinobacteria,bacteroidetes, gemmatimonadetes, chloroflexi, nitrospirae and unclassified phylum. Proteobacteria is the largest bacterial phylum in all samples, with a marked shift of the proportions of alpha-, beta-, and gammaproteobacteria. The results show that undisturbed soils are relatively more diverse and rich than subsided soils, and differences in abundances of dominant taxonomic groups between the two soil groups are visible. Compared with the control, soil nutrient contents decline achieves significant level in subsided soils. Correlational analysis showed bacterial diversity indices have significantly positive correlation with soil organic matter, total N, total P, and available K, but in negative relation with soil salinity.Ground subsidence noticeably affects the diversity and composition of soil microbial community. Degeneration of soil fertility and soil salinization inhibits the sole-carbon-source metabolic ability of microbial community, leading to the simplification of advantage species and uneven distribution of microbial species. This work demonstrates the great potential of pyrosequencing technique in revealing microbial diversity and presents background information of microbial communities of mine subsidence land. | Li Yuanyuan Chen Longqian Wen Hongyu Zhou Tianjian Zhang Ting | 2014 | International Journal of Mining Science and Technology2014，24，5： | 4 |
| 9 | Performance enhancement of sandwich panels with honeycomb–corrugation hybrid core显示文摘The concept of combining metallic honeycomb with folded thin metallic sheets(corrugation) to construct a novel core type for lightweight sandwich structures is proposed. The honeycomb–corrugation hybrid core is manufactured by filling the interstices of aluminum corrugations with precision-cut trapezoidal aluminum honeycomb blocks, bonded together using epoxy glue. The performance of such hybrid-cored sandwich panels subjected to out-of-plane compression, transverse shear, and three-point bending is investigated, both experimentally and numerically. The strength and energy absorption of the sandwich are dramatically enhanced, compared to those of a sandwich with either empty corrugation or honeycomb core. The enhancement is induced by the beneficial interaction effects of honeycomb blocks and folded panels on improved buckling resistance as well as altered crushing modes at large plastic deformation.The present approach provides an effective method to further improve the mechanical properties of conventional honeycomb-cored sandwich constructions with low relative densities. | Bin Han Wenbin Wang Zhijia Zhang Qiancheng Zhang Feng Jin Tianjian Lu | 2016 | Theoretical & Applied Mechanics Letters2016，6，1： | 4 |
| 10 | Low strain rate compressive behavior of high porosity closed-cell aluminum foams显示文摘The impact of a rigid body(protected structure) together with cushion material(cellular metal foam) on hard ground from a fixed height was investigated.An analytical one-degree-of-freedom colliding model(ODF-CM) was established to analyze the protection ability and energy absorption by the foam under low velocity impact conditions.For validation,drop hammer experiments were carried out for high porosity closed-cell aluminum foam specimens subjected to low velocity impact loading.The dynamic deformation behavior of the specimen was observed and the velocity attenuation of the drop hammer was measured.The results demonstrated that the aluminum foam had excellent energy absorption capabilities,with its dynamic compressive behavior similar to that obtained under quasi-static loading conditions.Finite element method(FEM) was subsequently employed to obtain stress distributions in the foam specimen.As the propagating period of stress in the specimen was far less than the duration of attenuation,the evolution of the stress was similar to that under quasi-static loading conditions and no obvious stress wave effect was observed,which agreed with the experimental observation.Finally,the predicted velocity attenuation by the ODF-CM was compared with both the experimental measurements and FEM simulation,and good agreements were achieved when the stress distribution was considered to be uniform and the 'quasi-static' compressive properties are employed. | LI BinChao ZHAO GuiPing LU TianJian | 2012 | Science China(Technological Sciences)2012，55，2： | 3 |
| 11 | Dynamic flow resistivity based model for sound absorption of multi-layer sintered fibrous metals显示文摘The sound absorbing performance of the sintered fibrous metallic materials is investigated by employing a dynamic flow resistivity based model,in which the porous material is modeled as randomly distributed parallel fibers specified by two basic physical parameters:fiber diameter and porosity.A self-consistent Brinkman approach is applied to the calculation of the dynamic resistivity of flow perpendicular to the cylindrical fibers.Based on the solved flow resistivity,the sound absorption of single layer fibrous material can be obtained by adopting the available empirical equations.Moreover,the recursion formulas of surface impedance are applied to the calculation of the sound absorption coefficient of multi-layer fibrous materials.Experimental measurements are conducted to validate the proposed model,with good agreement achieved between model predictions and tested data.Numerical calculations with the proposed model are subsequently performed to quantify the influences of fiber diameter,porosity and backed air gap on sound absorption of uniform(single-layer)fibrous materials.Results show that the sound absorption increases with porosity at higher frequencies but decreases with porosity at lower frequencies.The sound absorption also decreases with fiber diameter at higher frequencies but increases at lower frequencies.The sound absorption resonance is shifted to lower frequencies with air gap.For multi-layer fibrous materials,gradient distributions of both fiber diameter and porosity are introduced and their effects on sound absorption are assessed.It is found that increasing the porosity and fiber diameter variation improves sound absorption in the low frequency range.The model provides the possibility to tailor the sound absorption capability of the sintered fibrous materials by optimizing the gradient distributions of key physical parameters. | MENG Han AO QingBo TANG HuiPing XIN FengXian LU TianJian | 2014 | Science China(Technological Sciences)2014，57，11： | 3 |
| 12 | Experiment study of a quartz tube falling particle receiver显示文摘这篇论文论述特殊设计的掉落的粒子接收装置的试验性的评估。一个石英试管在设计,粒子没被风与征服被使用。集中的太阳的放射被吸收并且由稳固的粒子变换成热精力流动里面石英试管。几个实验被进行在太阳的炉子系统上测试接收装置的动态热表演。在实验期间,最大的粒子温度上升是 212C,与 61.2% 的效率,它在小规模粒子接收装置与 0.2 m 的掉落的距离显示出好热表演。平均插头粒子温度被直接正常的发光(DNI ) 影响,象风那样的另外的因素加速。当更小的稳固的粒子更容易在螺旋石英试管困住时,稳固的粒子与更高的温度获得更大的粘性。,当稳固的粒子的温度增加,硅碳化物的热能力与粒子温度的上升变得更大,硅碳化物的温度上升减少。 | Tianjian WANG Fengwu BAI Shunzhou CHU Xiliang ZHANG Zhifeng WANG | 2017 | Frontiers in Energy2017，11，4： | 3 |
| 13 | Penetration of sandwich plates with hybrid-cores under oblique ballistic impact显示文摘The oblique penetration performance of lightweight hybrid-cored sandwich plates are investigated numerically. To compose the hybrid-core, ceramic prisms are inserted into pyramidal metal lattice trusses and fixed using epoxy resin. Three-dimensional finite element simulations are carried out for the hybridcored sandwich impacted at 15°, 30°, 45°, and 60°obliquity by a hemispherical projectile. The ballistic limit, the energy absorbed by the constituting elements,and the critical oblique angle are quantified. The physical mechanisms underlying the failure and the influence of fundamental system parameters are explored.The angle of obliquity is found to have significant influence on the ballistic trajectory and erosion of the projectile, thus it is important for the impact response and penetration resistance of the sandwich. For oblique angles equal to or larger than45°, the projectile moves mainly horizontally and can not effectively penetrate across the sandwich. | Changye Ni Feng Jin Tianjian Lu | 2014 | Theoretical & Applied Mechanics Letters2014，4，2： | 3 |
| 14 | Novel cobalt base superalloy and its high-temperature flow behavior显示文摘包含钛和铝的新奇的钴底 superalloy 通过金属组织学,张力的测试,和高温度的等温的压缩变丑被调查。结果证明有罐头的钛和铝的合适的内容改进钴底 superalloy 的力量和韧性。Co3 (Ti,艾尔) 当新奇 superalloy 在 800 点是年老的时,有 L12 | TANG Chunfeng PAN Feng QU Xuanhui DUAN Baihua WANG Tianjian HE Xinbo | 2008 | Rare Metals2008，27，3： | 3 |
| 15 | Interleukin-6 signaling pathway in targeted therapy for cancer显示文摘 | Yuqi Guo Feng Xu TianJian Lu Zhenfeng Duan Zhan Zhang | 2012 | Cancer Treatment Reviews2012，，7： | 2 |
| 16 | Thermal stretching in two-phase porous media: Physical basis for Maxwell model显示文摘An alternate yet general form of the classical effective thermal conductivity model (Maxwell model) for two-phase porous materials is presented, serving an explicit thermo-physical basis. It is demonstrated that the reduced effective thermal conductivity of the porous media due to non-conducting pore inclusions is caused by the mechanism of thermal stretching, which is a combination of reduced effective heat flow area and elongated heat transfer distance (thermal tortuosity). | Xiaohu Yang Tianjian Lu Tongbeum Kim | 2013 | Theoretical & Applied Mechanics Letters2013，3，2： | 2 |
| 17 | Strength optimization of ultralight corrugated-channel-core sandwich panels显示文摘Novel ultralight sandwich panels, which are comprised of corrugated channel cores and are faced with two identical solid sheets,subjected to generalized bending are optimally designed for minimum mass. A combined analytical and numerical(finite element) investigation is carried out. Relevant failure mechanisms such as face yielding, face buckling, core yielding and core buckling are identified, the load for each failure mode derived, and the corresponding failure mechanism maps constructed. The analytically predicted failure loads and failure modes are validated against direct finite element simulations, with good agreement achieved. The optimized corrugated channel core is compared with competing topologies for sandwich construction including corrugations, honeycombs and lattice trusses, and the superiority of the proposed structure is demonstrated. Corrugated-channel-core sandwich panels hold great potential for multifunctional applications, i.e., simultaneous load bearing and active cooling. | ZHAO ZhenYu LI Lang WANG Xin ZHANG QianCheng HAN Bin LU TianJian | 2019 | Science China(Technological Sciences)2019，62，8： | 2 |
| 18 | Experimental investigation of chimney-enhanced natural convection in hexagonal honeycombs显示文摘The natural convective heat transfer performance of an aluminum hexagonal honeycomb acting as a novel heat sink for LED cooling is experimentally investigated. The concept of adding an adiabatic square chimney extension for heat transfer enhancement is proposed, and the effects of chimney shape, height, and diameter are quantified. The average Nuav of a heated honeycomb with straight chimney is significantly higher than that without chimney,and the enhancement increases with increasing chimney height. At a given chimney height, honeycombs with divergent chimneys perform better than those with convergent ones. For a fixed divergent angle, the Nuav number increases monotonically with increasing chimney height. In contrast, with the convergent angle fixed, there exists an optimal chimney height to achieve maximum heat transfer. | Xiaohu Yang Jiaxi Bai Tianjian Lu Tongbeum Kim | 2014 | Theoretical & Applied Mechanics Letters2014，4，3： | 2 |
| 19 | Dynamic response of ultralight all-metallic sandwich panel with 3D tube cellular core to shallow-buried explosives显示文摘The underbody of a vehicle system, either military or civil, is typically made of a relatively thin metallic plate, thus vulnerable to mine blast attacks. To improve the blast resistance, a multitude of protective structures have been proposed as attachments to the thin plate. In the present study, a novel ultralight all-metallic sandwich panel with three-dimensional(3D) tube cellular cores mounted to the vehicle underbody was envisioned as such a protective system. A metallic substrate(mimicking vehicle bottom)was placed above the proposed sandwich panel to construct a sandwich-substrate combinative structure. A series of sandwich panels having 3D tube cellular cores were fabricated via argon protected welding and laser welding. Mechanical responses of the combinative structure subjected to the denotation of 6 kg TNT explosives shallow-buried in dry sand were experimentally measured. Full numerical simulations with the method of finite elements(FE) were subsequently carried out to explore the physical mechanisms underlying the observed dynamic performance and quantify the effects of key geometrical parameters and connection conditions of the protective system. The performance of the proposed sandwich panel under shallow-buried explosives was also compared with competing sandwich constructions having equal mass. Finally, a preliminary optimal design of the 3D tube cellular core was carried out. | ZHANG DuJiang ZHAO Zhen Yu DU ShaoFeng CHEN WeiJie YANG Fan NI ChangYe YANG ZhiKun LU TianJian | 2021 | Science China(Technological Sciences)2021，64，7： | 2 |
| 20 | Analytical design of effective thermal conductivity for fluid-saturated prismatic cellular metal honeycombs显示文摘A comparative optimal design of fluid-saturated prismatic cellular metal honeycombs(PCMHs) having different cell shapes is presented for thermal management applications. Based on the periodic topology of each PCMH, a unit cell(UC) for thermal transport analysis was selected to calculate its effective thermal conductivity. Without introducing any empirical coefficient, we modified and extended the analytical model of parallel–series thermal–electric network to a wider porosity range(0.7 ~ 0.98) by considering the effects of two-dimensional local heat conduction in solid ligaments inside each UC. Good agreement was achieved between analytical predictions and numerical simulations based on the method of finite volume. The concept of ligament heat conduction efficiency(LTCE) was proposed to physically explain the mechanisms underlying the effects of ligament configuration on effective thermal conductivity(ETC).Based upon the proposed theory, a construct strategy was developed for designing the ETC by altering the equivalent interaction angle with the direction of heat flow: relatively small average interaction angle for thermal conduction and relatively large one for thermal insulation. | Wenbin Wang Xiaohu Yang Bin Han Qiancheng Zhang Xiangfei Wang Tianjian Lu | 2016 | Theoretical & Applied Mechanics Letters2016，6，2： | 2 |
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