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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Complementary roles of interventional radiology and therapeutic endoscopy in gastroenterology显示文摘Acute upper and lower gastrointestinal bleeding, enteral feeding, cecostomy tubes and luminal strictures are some of the common reasons for gastroenterology service. While surgery was initially considered the main treatment modality, the advent of both therapeutic endoscopy and interventional radiology have resulted in the paradigm shift in the management of these conditions. In this paper, we discuss the patient's work up, indications, and complementary roles of endoscopic and angiographic management in the settings of gastrointestinal bleeding, enteral feeding, cecostomy tube placement and luminal strictures. These conditions often require multidisciplinary approaches involving a team of interventional radiologists, gastroenterologists and surgeons. Further, the authors also aim to describe how the fields of interventional radiology and gastrointestinal endoscopy are overlapping and complementary in the management of these complex conditions. | David M Ray Indu Srinivasan Shou-jiang Tang Andreas S Vilmann Peter Vilmann Timothy C McCowan Akash M Patel | 2017 | World Journal of Radiology2017，9，3： | 2 |
| 3 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 4 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 5 | Solution-liquid-solid growth of crystalline iii-v semiconductors--An analogy to vapor-liquid-solid growth 显示文摘 | Trentler Timothy J Hickman Kathleen M Goel Subhash C | 1995 | Science1995，270，5243： | 1 |
| 6 | Firm,Strategic Group,and Industry Influences on Performance显示文摘 | Jeremy C Short David J Ketchen JR Timothy B Palmer G Tomas M Hult | 2007 | Strategic Management Journal2007，28，： | 1 |
| 7 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 8 | Robust frequency and timing synchronization for OFDM 显示文摘 | TIMOTHY M DONALD C C | 1997 | IEEE Trans Commun1997，45，12： | 1 |
| 9 | Robust frequency and timing synchronization for OFDM 显示文摘 | Schmidl Timothy M Cox Donald C | 1997 | IEEE Transactions on Communications1997，45，12： | 1 |
| 10 | Isolation and characterization of avian influenza viruses,including highly pathogenic H5N1,from poultry in live bird markets in Hanoi,Vietnam,in 2001显示文摘 | Doan C N Timothy M U Samadhan J | 2005 | Journal of Virology2005，79，7： | 1 |
| 11 | Dynamic stability ofa microgrid with an active load 显示文摘 | Bottrell N Prodanovic M Timothy C G | 2013 | IEEE Transactions onPower Electronics2013，28，11： | 1 |
| 12 | PI3K/Akt regulates early differentiation in human laryngeal keratinocytes 显示文摘 | Raduwan D Timothy C Bettie M | 2005 | In Vitro Cellular & Development Bio Ani2005，41，3： | 1 |
| 13 | Startup and operation of a supercritical carbon dioxide Brayton cycle 显示文摘 | Eric M C Timothy L C Christopher P S | 2014 | Journal of Engineering for Gas Turbines and Power2014，136，： | 1 |
| 14 | Robust frequency and timing synchronization for OFDM 显示文摘 | TIMOTHY M S DONALD C C | 1997 | IEEE Trans Comm1997，45，： | 1 |
| 15 | 'Click' modification of silica surfaces and glass microfluidic channels显示文摘 | Prakash Shaurya Long M Timothy Selby C John | 2007 | Analytical Chemistry2007，79，4： | 1 |
| 16 | Comparative approaches for assessing network vulnerability显示文摘 | Tony H G Timothy C M Alan T M | 2008 | International Regional Science Review2008，31，1： | 1 |
| 17 | Silver salt facilitated transport membranes for olefin/paraffin separations: Carrier instability and a novel regeneration method显示文摘 | Timothy C M Rolande B Isabelle C et a1 | 2013 | J Membr Sci2013，447，： | 1 |
| 18 | Helicobacter pylori infection显示文摘 | C Stewart Goodwin Michael M Mendall Timothy C Northfield | 1997 | 1997 (9047)1997，，9047： | 1 |
| 19 | Stategic risk:an ordinal approach 显示文摘 | JAMES M C TIMOTHY W R | 1992 | Management Science1992，，12： | 1 |
| 20 | IBM's S/390 G5 microprocessor design显示文摘 | Timothy J S Robert M Mark A C | 1999 | Micro IEEE1999，19，2： | 1 |
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