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| 1 | Cardiac rehabilitation and exercise therapy in the elderly: Should we invest in the aged?显示文摘冠的心疾病(CHD ) 是世界范围的死亡的领先的原因并且在病人之中变得逐渐地流行 65 岁以上。老病人在为复杂并发症的更高的风险并且在一个心血管的事件以后加速物理 deconditioning,特别与他们的更年轻的对应物相比。最后几十年是到与 CHD 在病人之中在死亡,锻练能力,心理风险因素,发炎,和肥胖上表明了心脏的康复(CR ) 和锻练治疗的有益的效果的多重研究的厕所。不幸地,这个领域里的可得到的数据的重要部分与更年轻的病人相关。可行解释是更老的病人在为以病人开始并且延长到医生的多重原因的这些节目是非常未被充分代表的。在这篇文章,我们将考察 CR 节目的好处在之中老,以及一些妨碍他们的参予的障碍。 | Arthur R Menezes Carl J Lavie Richard V Milani Ross A Arena Timothy S Church | 2012 | Journal of Geriatric Cardiology2012，9，1： | 25 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Dysphagia after vertical sleeve gastrectomy: Evaluation of risk factors and assessment of endoscopic intervention显示文摘AIM To evaluate the risks of medical conditions, evaluate gastric sleeve narrowing, and assess hydrostatic balloon dilatation to treat dysphagia after vertical sleeve gastrectomy(VSG).METHODS VSG is being performed more frequently worldwide as a treatment for medically-complicated obesity, and dysphagia is common post-operatively. We hypothesize that post-operative dysphagia is related to underlying medical conditions or narrowing of the gastric sleeve. This is a retrospective, single institution study of consecutive patients who underwent sleeve gastrectomy from 2013 to 2015. Patients with previous bariatric procedures were excluded. Narrowing of a gastric sleeve includes: inability to pass a 9.6 mm gastroscope due to stenosis or sharp angulation or spiral hindering its passage.RESULTS Of 400 consecutive patients, 352 are included; the prevalence of dysphagia is 22.7%; 33 patients(9.3%) have narrowing of the sleeve with 25(7.1%) having sharp angulation or a spiral while 8(2.3%) have a stenosis. All 33 patients underwent balloon dilatation of the gastric sleeve and dysphagia resolved in 13 patients(39%); 10 patients(30%) noted resolution of dysphagia after two additional dilatations. In a multivariate model, medical conditions associated with post-operative dysphagia include diabetes mellitus, symptoms of esophageal reflux, a low whole blood thiamine level, hypothyroidism, use of non-steroidal anti-inflammatory drugs, and use of opioids.CONCLUSION Narrowing of the gastric sleeve and gastric sleeve stenosis are common after VSG. Endoscopic balloon dilatations of the gastric sleeve resolves dysphagia in 69% of patients. | Anand Nath Sayali Yewale Tung Tran John S Brebbia Timothy R Shope Timothy R Koch | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 4 | Metastatic recurrence to a solitary lymph node four years after hepatic lobectomy for primary hepatocellular carcinoma显示文摘This report describes a patient that developed recurrent metastatic hepatocellular carcinoma(HCC) to a suprapancreatic lymph node four years after being treated for primary HCC via complete left hepatectomy. Metastatic HCC was proven by pathologic confirmation. The report addresses the role of surgical resection as a treatment modality for recurrent HCC to solitary lymph nodes. The role of biological chemotherapy as adjuvant treatment is also addressed. | Michael L Caparelli Nathan J Roberts Timothy S Braverman Robert M Stevens Edward R Broun Shyam Allamaneni | 2016 | World Journal of Hepatology2016，8，23： | 2 |
| 5 | Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in florida显示文摘 | LOUIS J GUILLETTE JR TIMOTHY S GROSS GREG R MASSON | 1994 | Environmental Health Perspectives1994，102，8： | 1 |
| 6 | Tillage effects on soil hydraulic properties in space and time:State of the science显示文摘 | Mark W S Timothy R G James C A | 2008 | Soil and Tillage Research2008，99，1： | 1 |
| 7 | A hardware-efficient, multirate, digital channelized receiver architecture显示文摘 | DANIEL R Z DAVID L S TIMOTHY W F | 1998 | IEEE Transactions on Aerospace and Electronic Systems1998，34，1： | 1 |
| 8 | Insect ryanodine receptors:molecular targets for novel pest control chemicals显示文摘 | David B S Daniel C Timothy R C | 2008 | Invent Neurosci2008，8，： | 1 |
| 9 | Extracranial internal carotid artery pseudoaneurysm 显示文摘 | Sood S Timothy J Anthony R et at | 2000 | Am J Otolaryngo2000，21，4： | 1 |
| 10 | Lung Cancer Incidence Trends Among Men and Women - United States, 2005-2009显示文摘 | Henley S Jane Richards Thomas B Underwood J Michael Eheman Christie R Plescia Marcus McAfee Timothy A | 2014 | Morbidity and Mortality Weekly Report2014，，1： | 1 |
| 11 | Multisection dynamic CT perfusion for acute cerebral ischemia:the 'Toggling-table' technique显示文摘 | Heidi R Timothy R Wade S | 2001 | AJNR2001，22，6： | 1 |
| 12 | Functional expression of olfactory-adrenergic receptor chimeras and intracellular retention of heterologously expressed olfactory receptors显示文摘 | Timothy S McClintock Teresa M Landers Alexander A Gimelbrant Lynn Z Fuller Brian A Jackson Channa K Jayawickreme Michael R Lerner | 1997 | Molecular Brain Research1997，，2： | 1 |
| 13 | Leptin suppression of insulin secretion by the activation of ATP- sensitive K+ channels in pancreatic- Bcell 显示文摘 | Timothy J T J Kiefer R S HollerC A | 1997 | Diabetes1997，46，： | 1 |
| 14 | Architecture and stratigraphy of alluvial deposits,Morrison Formation(Upper Jurassic),Utah显示文摘 | Audun V K Edwin R S Timothy A C | 2008 | AAPG Bull2008，92，8： | 1 |
| 15 | Designing and Deploying a Building-Wide Cognitive Radio Network Testbed 显示文摘 | Timothy R N Shajedul H S M DePoy E | 2010 | IEEE Communication Magazines2010，48，9： | 1 |
| 16 | Heme and iron metabolism: Role in cerebral hemorrhage显示文摘 | KENNETH R W FRANK R S TIMOTHY D A | 2003 | Cerebral Blood Flow & Metabolism2003，23，： | 1 |
| 17 | Evaluation of WHO criteria for identifying patients with severe acute respiratory syndrome out -of- hospital: prospective observational study显示文摘 | Timothy H R Peter A C Devilliers S | 2003 | BMJ2003，326，21： | 1 |
| 18 | Influence of the molar mass distribution on the elongational behavior of polymer solutions in capillary breakup显示文摘 | Lucy E R Timothy P S Justin J C | | 0，，1： | 1 |
| 19 | Tillage effects on soil hydraulic properties in space and time: State of the science 显示文摘 | Mark W S Timothy R G James C A | 2008 | Soil and Tillage Research2008，99，1： | 1 |
| 20 | Rapid method for the isolation of full length adenoviral genomes by bacterial intermolecular homologous recombination显示文摘 | Youil R Timothy J T Qin S | 2001 | J Virol Methods 20012001，9197，： | 1 |
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