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| 1 | Number of COVID-19 cases required in a population to detect SARS-CoV-2 RNA in wastewater in the province of Alberta, Canada:Sensitivity assessment显示文摘With a unique and large size of testing results of 1,842 samples collected from 12 wastewater treatment plants (WWTP) for 14 months through from low to high prevalence of COVID-19,the sensitivity of RT-qPCR detection of SARS-CoV-2 RNA in wastewater that correspond to the communities was computed by using Probit analysis.This study determined the number of new COVID-19 cases per 100,000 population required to detect SARS-CoV-2RNA in wastewater at defined probabilities and provided an evidence-based framework of wastewater-based epidemiology surveillance (WBE).Input data were positive and negative test results of SARS-CoV-2 RNA in wastewater samples and the corresponding new COVID-19 case rates per 100,000 population served by each WWTP.The analyses determined that RT-qPCR-based SARS-CoV-2 RNA detection threshold at 50%,80%and 99%probability required a median of 8 (range:4-19),18 (9-43),and 38 (17-97) of new COVID-19 cases/100,000,respectively.Namely,the positive detection rate at 50%,80%and 99%probability were 0.01%,0.02%,and 0.04%averagely for new cases in the population.This study improves understanding of the performance of WBE SARS-CoV-2 RNA detection using the large datasets and prolonged study period.Estimated COVID-19 burden at a community level that would result in a positive detection of SARS-CoV-2 in wastewater is critical to support WBE application as a supplementary warning/monitoring system for COVID-19 prevention and control. | Qiaozhi Li Bonita E.Lee Tiejun Gao Yuanyuan Qiu Erik Ellehoj Jiaao Yu Mathew Diggle Graham Tipples Rasha Maal-Bared Deena Hinshaw Christopher Sikora Nicholas J.Ashbolt James Talbot Steve E.Hrudey Xiaoli Pang | 2023 | Journal of Environmental Sciences2023，，3： | 2 |
| 2 | How Many Infective Viral Particles are Necessary for Successful Mass Measles Immunization by Aerosol 显示文摘 | COATES A L TIPPLES G LEUNG K | 2006 | Vaccine2006，24，10： | 1 |
| 3 | Mutation in HBVRNA dependent DNA polymerase confers resistance to lamivudine in vivo显示文摘 | Tipples GA Ma MM Fischer KP | 1996 | Hepatology1996，24，3： | 1 |
| 4 | Implications of the mechanical development of bread dough by means of sheeting rolls显示文摘 | KILBORN R H TIPPLES K H | 1974 | Cereal Chem1974，，51： | 1 |
| 5 | High prevalence of macrolide re-sistant Treponema pallidum srains in a London centre 显示文摘 | Tipple C Mcclure MO Taylor GP | 2011 | SexTransm Infect2011，87，6： | 1 |
| 6 | Cyclooxygenase-2 in newborn hyperoxic lung injury 显示文摘 | Britt RD Jr Velten M Tipple TE | 2013 | Free Radic Biol Med2013，61，8： | 1 |
| 7 | Sepsis associ- ated with transfusion of red contaminated with Yerisinia enterocolitica显示文摘 | Tipple MA Bland LA Murphy JJ | 1990 | Transfusion1990，30，3： | 1 |
| 8 | Syphilitic aorta: exploring the bigger picture 显示文摘 | Sacks R Tipple C Goldmeier D | 2010 | Int J STD AIDS2010，21，8： | 1 |
| 9 | The role of eolposcopy in the follow up of women treated for cervical intraepithelial 显示文摘 | Soutter WP Buter JS Tipples M | 2006 | BJOG2006，113，5： | 1 |
| 10 | Urban forestry administration in the Netherlands 显示文摘 | Tipple T J | 1990 | Soc Nat Resour1990，3，4： | 1 |
| 11 | Hospital housekeepers:victims of ineffective hospital waste management显示文摘 | REAM P S TIPPLE A F SALGADO T A | 2015 | Arch Environ Occup Health2015，，： | 1 |
| 12 | Conversion of some azaheterocyclic-acetic esters and acetonitriles into fused heterocyeles 显示文摘 | David M Mckinnon Perry Spevack Graham Tipples | 1988 | Can J Chem1988，66，： | 1 |
| 13 | A real-time PCR assay for the detection of varicella-zoster virus DNA and differentiation of vaccine, wild-type and control strains显示文摘 | Tipples GA Safronetz D Gray M | 2003 | J Virol Med2003，113，： | 1 |
| 14 | Mutations in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo显示文摘 | Tipples GA Ma MM Fischer KP | 1996 | Hepatology1996，24，： | 1 |
| 15 | Syphilis testing, typing, and treatment follow-up: a new era for an old disease显示文摘 | Tipple C Taylor GP | 2015 | Curr Opin In- fect Dis2015，28，： | 1 |
| 16 | Generation of stable cell lines expressing lamivudine-resistant hepatitis B virus for antiviral-compound screening显示文摘 | Wahers KA Tipples GA Allen MI | 2003 | Antimicrob Agents Chemothe2003，47，6： | 1 |
| 17 | Differentiation and quantitation of human herpesviruses 6A,6B and 7 by real- time PCR 显示文摘 | Safronetz D Humar A Tipples GA | 2003 | J Virol Methods2003，112，12： | 1 |
| 18 | Removal trichothecenes from wheat infected with Fusarium head by specific gravity table of tombstone kernels and associated blight显示文摘 | Tkachuk R Dexter JE Tipples KH | 1991 | Cereal Chem1991，68，4： | 1 |
| 19 | The role of colposcopy in the follow up of women treated for cervical intraepithelial neoplasia显示文摘 | Soutter WP Butler JS Tipples M | 2006 | BJOG2006，113，5： | 1 |
| 20 | Illness in hemodialysis paitents after exposured to ehloramines contaminated dialysate显示文摘 | Tipple MA Shusterman N Bland LA | 1991 | ASAIO Trans1991，3，： | 1 |
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