|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Engineering a simple, efficient code generator generator 显示文摘 | CHRISTOPER W F DAVID R H TODD A P | 1992 | ACM Letters on Programming Languages and Systems1992，1，3： | 1 |
| 3 | The Bowen ratio-energy balance method for estimating latent heat flux of irrigated alfalfa evaluated in a semi-arid,advective environment显示文摘 | Todd R W Evett S R Howell T A | 2000 | Agic For Meteorol2000，103，： | 1 |
| 4 | Evaluation of am- monium molybdophosphate polyacrylonitrile as a cesium se- lective sorbent for the removal of I37Cs from acidic nuclear waste solutions显示文摘 | Tranter T Herbst R S Todd T A | 2002 | Adv Environ Res2002，6，： | 1 |
| 5 | Regulation of transendothelial neutrophil migration by endogenous interleukin 8 显示文摘 | Huber A R Kunker S L Todd R F | 1991 | Science1991，254，： | 1 |
| 6 | Cesium sorption from concentrated acidic tank wastes using ammonium mo- lybdophosphate-polyacrylonitrile composite sorbents显示文摘 | Todd T A Mann N R Traner T J | 2002 | J Radioanal Nucl Chem2002，254，1： | 1 |
| 7 | Tin-transition metal-carbon systems for lithium-ion battery negative electrodes显示文摘 | Todd A D W Mar R E Dahn J R | 2007 | Journal of the Electrochemical Society2007，154，6： | 1 |
| 8 | Perceived usefulness, ease of use, and usage of information technology: A replication显示文摘 | Adams D A Nelson R R and Todd P A | 1992 | MIS Quarterly1992，16，2： | 1 |
| 9 | Soil temperature and water evaporation of small steel and plastic lysimeters replaced daily显示文摘 | Todd R W Evett S R Howell T A | 2000 | Soil Science2000，165，11： | 1 |
| 10 | Perceived nsefulness, ease of use, and usage of information technology: a replication 显示文摘 | Adams D A Nelson R R Todd P A | 1992 | blIS Quarterly1992，16，2： | 1 |
| 11 | Nutritional status of hae- modialysis patients:comparison of Australian cohorts of Aborigi- nal and European descent显示文摘 | Todd A Carroll R Gallagher M | 2013 | Nephrology (Carlton)2013，18，12： | 1 |
| 12 | Using the Monte Carlo-Library Least-Squares (MCLLS) approach for the invivo XRF measurement of lead in bone显示文摘 | Guo W J Gardner R P Todd A C | 2004 | Nuclear Instruments and Methods in Physics Research A2004，516，23： | 1 |
| 13 | Induced pyroelectricity in sputtered lead scandium tantalate films and their merit for IR detector arrays显示文摘 | WATTON R TODD M A | 1991 | Ferroelectrics1991，118，： | 1 |
| 14 | Combinatorial study of tin-transition metal alloys as negative electrodes for lithiumion batteries显示文摘 | Todd A D W Mar R E Dahn J R | 2006 | J Electrochem Soc2006，153，10： | 1 |
| 15 | Crossflow filtration testing of INEEL radioactive and non-radioactive waste slurries显示文摘 | Mann N R Todd T A | 2000 | Chemical Engineering Journal2000，80，13： | 1 |
| 16 | Stress sensitivity of low-permeability sandstones from the rotliegendes sandstone显示文摘 | Farquhar R A Smart B G D and Todd A C | 1993 | SPE265011993，，： | 1 |
| 17 | Prediction of human oral cancer radiation responsiveness by histone (H3) mRNA in situ hybridization: a preliminary report 显示文摘 | Donoff RB Todd R Elovic A | 1998 | J Oral Maxillofac Surg1998，56，12： | 1 |
| 18 | Tomographic reconstruction of air pollutants: evaluation of measurement geometries 显示文摘 | L A Todd R Bhattacharyya | 1997 | Appl Opt1997，36，30： | 1 |
| 19 | Increased Sensi- tivity of the Rapid Hydrophobic Grid Membrane Filter Enzyme- Labeled Antibody Procedure for Eschcrichia coli O157 Detection in Foods and Bovine Feces显示文摘 | Szabo R A Todd E C D Mackenzie J M | 1990 | Applied and Environmental Mi- crobiology1990，56，11： | 1 |
| 20 | Rapid Hydrophobic Grid Membrane Filter-Enzyme-Labeled Antibody Procedure for Identification and Enumeration of Escherichia coil O157 in Foods显示文摘 | Todd E C D Szabo R A Peterkin P I | 1988 | Applied and Environmental Microbiology1988，54，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员