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| 1 | 靶向Jak/Stat通路作为Akt/β-联蛋白诱导的肝细胞癌SP/CD44+肿瘤细胞的治疗策略显示文摘【据《J Hepatol》2019年9月报道】题:靶向Jak/Stat通路作为Akt/β-联蛋白诱导的肝细胞癌SP/CD44+肿瘤细胞的治疗策略(作者Toh TB等)肝切除和肝移植以及辅助放化疗是肝细胞癌(HCC)治疗的主要手段。由于其频繁复发和肝内转移,HCC患者5年生存率仍然很差。目前仅索拉非尼和仑伐替尼被批准用于晚期、非切除的HCC的一线治疗,但其生存获益有限。因此需要确定新的治疗靶点以改进目前HCC治疗方式。 | 丁梦梦 高沿航 TOH TB LIM JJ HOOI L | 2020 | 临床肝胆病杂志2020，36，3： | 16 |
| 2 | Cytotoxic CD8+ T cells and tissue resident memory cells in colorectal cancer based on microsatellite instability and BRAF status显示文摘BACKGROUND Recent studies in non-colorectal malignancy have associated T resident memory(T_(RM)) cells with improved patient survival. It is unknown if T_(RM) plays a role in colorectal cancer(CRC).AIM To examine the potential role of T_(RM) cells in providing immunogenicity in CRC stratified by microsatellite instability(MSI) and BRAF status.METHODS Patients with known MSI and BRAF mutation status were eligible for inclusion in this study. CRC tumour sections stained with haematoxylin and eosin were microscopically reviewed and the images scanned prior to assessment for location of invading edge and core of tumour. Sequential sections were prepared for quantitative multiplex immunohistochemistry(IHC) staining. Opal Multiplex IHC staining was performed with appropriate positive and negative controls and imaged using a standard fluorescent microscope fitted with a spectral scanning camera(Mantra) in conjunction with Mantra snap software. Images were unmixed and annotated in in Form 2.2.0. Statistical analysis was performed using Graphpad Prism Version 7 and Stata Version 15.RESULTS Seventy-two patients with known MSI and BRAF status were included in the study. All patients were assessed for MSI by IHC and high resolution capillary electrophoresis testing and 44 of these patients successfully underwent quantitative multiplex IHC staining. Overall, there was a statistically significant increase in CD8+ T_(RM) cells in the MSI(BRAF mutant and wild type) group over the microsatellite stable(MSS) group. There was a statistically significant difference in CD8+ T_(RM) between high level MSI(MSI-H):BRAF mutant [22.57, 95% confidence interval(CI): 14.31-30.84] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0076 and MSI-H:BRAF wild type [16.18(95%CI: 10.44-21.93)] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0279. There was no statistically significant difference in CD8 T cells(both CD8+CD103-and CD8+CD103+T_(RM)) between MSI-H: BRAF mutant and wild type CRC.CONCLUSION This study has shown that CD8+ T_(RM) are found in greater abundance in MSI-H CRC, both BRAF mutant and MSI-H:BRAF wild type, when compared with their MSS counterpart. CD8+ T_(RM) may play a role in the immunogenicity in MSI-H CRC(BRAF mutant and BRAF wild type). Further studies should focus on the potential immunogenic qualities of T_(RM) cells and investigate potential immunotherapeutic approaches to improve treatment and survival associated with CRC. | James Wei Tatt Toh Angela L Ferguson Kevin J Spring Hema Mahajan Umaimainthan Palendira | 2021 | World Journal of Clinical Oncology2021，12，4： | 2 |
| 3 | Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation显示文摘 | NICOLSON G L NAWA A TOH Y | 2003 | Clin Exp Metastasis2003，20，： | 1 |
| 4 | Fabrication and characterization of anatase/rutile-TiO2 thin films by magnetron sputtering:a review显示文摘 | TANEMURA S MIAOA L WUNDERLICH W TANEMURA MASAKI MORI Y TOH S KANEKO K | 2005 | Science and Technology of Advanced Materials2005，，6： | 1 |
| 5 | The role of the MTA family and their encoded proteins in human cancets:molecular functions and clinical implica- tions 显示文摘 | Toh Y Nicolson G L | 2010 | Clin Exp Metastasis2010，26，3： | 1 |
| 6 | Inhibition of mi- croRNA-29b reduces murine abdominal aortic aneurysm development 显示文摘 | Maegdefessel L Azuma J Toh R | 2012 | J C lin Invest2012，122，2： | 1 |
| 7 | Inhibition of microRNA- 29b reduces murine abdominal aortic aneurysm development显示文摘 | Maegdefessel L Azuma J Toh R | 2012 | J Clin Invest2012，122，2： | 1 |
| 8 | Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic lin- ezolid显示文摘 | Toh S M Xiong L Arias C A et at | 2007 | Mol Microbiol2007，64，6： | 1 |
| 9 | A new torque and flux controller for direct torque control of induction machines显示文摘 | IDRIS N R N TOH C L | 2006 | IEEE Transactions on Industry Applications2006，42，6： | 1 |
| 10 | Candidate metastasis-associated genes of the rat 13762NF mammary adenocarcinoma显示文摘 | PENCIL S D TOH Y NICOLSON G L | 1993 | Breast Cancer Res Treat1993，25，2： | 1 |
| 11 | Surface-roughness study using la- ser speckle method 显示文摘 | TOH S L SHANG H M TAY C J | 1998 | Optics and Lasers in Engineering1998，29，6： | 1 |
| 12 | The Ishiguro extension block technique for the treatment of mallet finger fracture:indications and clinical results显示文摘 | Pegoli L Toh S Arai K | 2003 | J Hand Surg2003，28，： | 1 |
| 13 | Transcorporal artificial urinary sphincter cuff placement in cases requiring revision for erosion and urethral atrophy 显示文摘 | Guralnick M L Miller E Toh K L | 2002 | J Urol2002，167，5： | 1 |
| 14 | Tissue engineering techniquesin tendon and ligament replacement显示文摘 | Goh J C Ouyang H W Toh S L | 2004 | Med J Malaysia2004，，： | 1 |
| 15 | Role of IL-17 in the Thl systemic defects in rheumatoid arthritis through se leetive IL-12R beta2 inhibition显示文摘 | TOH M L KAWASHIMA M HOT A | 2010 | Ann Rheum Dis2010，69，8： | 1 |
| 16 | The role of the MTA family and their encoded proteins in human cancers:molecular functions and clinical implica- tions 显示文摘 | Toh Y Nicolson G L | 2010 | Clin Exp Metastasis2010，26，3： | 1 |
| 17 | Gastric H+ ,K+ -daenosine triphosphatase β-subunit is required for normal function, development, and membrane structure of mouse parietal cells显示文摘 | Scarff K L Judd L M Toh B H | 1999 | Gastroenterology1999，117，3： | 1 |
| 18 | The Impact of R&D on Value Added for Domestic and Foreign Firms in a Newly Indus- trialized Economy 显示文摘 | Tsang E W K Yip P S L Toh M H | 2008 | International Business Review2008，17，4： | 1 |
| 19 | Calculation of pseudospectra by the Arnoldi iteration 显示文摘 | Toh K C Trefethen L N | 1996 | SIAM J Sci Comput1996，17，： | 1 |
| 20 | Design for validation of acute myocardial infarction cases in mini-sentinel显示文摘 | Cutrona S L Toh S Iyer A | 2012 | Pharmacoepidemi- ol Drug Saf2012，21，1： | 1 |
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