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| 1 | Clinical relevance of fluorodeoxyglucose positron emission tomography/computed tomography and magnifying endoscopy with narrow band imaging in decision-making regarding the treatment strategy for esophageal squamous cell carcinoma显示文摘BACKGROUND Recent advances in endoscopic technology,especially magnifying endoscopy with narrow band imaging(ME-NBI)enable us to detect superficial esophageal squamous cell carcinoma(ESCC),but determining the appropriate method of resection,endoscopic resection(ER)vs surgical resection,is often challenging.Recently,several studies have reported that 18F-fluorodeoxyglucose positron emission tomography(FDG-PET)is a useful indicator for decision-making regarding treatment for superficial ESCC.Although,there are not enough reports on association between FDG-PET uptake and clinicopathological characteristics of superficial ESCC.And,there are not enough reports on evaluating the usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.This study evaluated clinical relevance of FDG-PET and ME-NBI in decision-making regarding the treatment strategy for ESCC.AIM To investigate the association between FDG uptake and the clinicopathological characteristics of superficial ESCC and its usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.METHODS A database of all patients with superficial ESCC who had undergone both MENBI and FDG-PET for pre-treatment staging at Aichi Cancer Center Hospital between January 2008 and November 2018 was retrospectively analyzed.FDG uptake was defined positive or negative whether the primary lesion was visualized or could be distinguished from the background,or not.The invasion depth of ESCC was classified according to the Japan Esophageal Society.Primary endpoint is to evaluate the association between FDG uptake and clinicopathological characteristics of superficial ESCC.Secondary endpoint is to investigate the efficacy of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.RESULTS A total of 82 lesions in 82 patients were included.FDG-PET showed positive uptake in 29(35.4%)lesions.Univariate analysis showed that uptake of FDG-PET had significant correlations with circumferential extension(P=0.014),pathological depth of tumor invasion(P<0.001),infiltrative growth pattern(P<0.001),histological grade(P=0.002),vascular invasion(P=0.001),and lymphatic invasion(P<0.001).On multivariate analysis,only depth of tumor invasion was independently correlated with FDG-PET/computed tomography visibility(P=0.018).The sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy of Type B2 in ME-NBI for the invasion depth of T1a muscularis mucosae and T1b upper submucosal layer were 68.4%/79.4%/50.0%/89.3%/76.8%,respectively,and those of Type B3 for the depth of T1b middle and deeper submucosal layers(SM2 and SM3)were 46.7%/100%/100%/89.3%/90.2%,respectively.On the other hand,those of FDGPET for SM2 and SM3 were 93.3%/77.6%/48.2%/98.1%/80.5%,respectively,whereas,if the combination of positive FDG uptake and type B2 and B3 was defined as an indicator for radical esophagectomy or definitive chemoradiotherapy,the sensitivity,specificity,PPV,NPV,and accuracy were 78.3%/91.5%/78.3%/91.5%/87.8%,respectively.CONCLUSION FDG uptake was correlated with the invasion depth of superficial ESCC.Combined use of FDG-PET and ME-NBI,especially with the microvascular findings of Type B2 and B3,is useful to determine whether ER is indicated for the lesion. | Kazuhiro Toriyama Masahiro Tajika Tsutomu Tanaka Makoto Ishihara Yutaka Hirayama Sachiyo Onishi Nobumasa Mizuno Takamichi Kuwahara Nozomi Okuno Shinpei Matsumoto Eiichi Sasaki Tetsuya Abe Yasushi Yatabe Kazuo Hara Keitaro Matsuo Tsuneo Tamaki Yasumasa Niwa | 2019 | World Journal of Gastroenterology2019，25，46： | 7 |
| 2 | Serum Neutrophil Gelatinase-associated Lipocalin(NGAL)Is Elevated in Patients with Asthma and Airway Obstruction显示文摘Neutrophilic airway inflammation is one of the features of severe asthma.Neutrophil gelatinase-associated lipocalin(NGAL),or lipocalin-2,is a glycoprotein associated with neutrophilic inflammation and can be detected in blood.Recently,blood NGAL levels have been reported to be elevated in chronic obstructive pulmonary disease.However,the clinical significance of serum NGAL levels in patients with asthma has not been elucidated.The aim of this study was to explore the association between serum NGAL level and clinical parameters in patients with asthma.Sixty.one non-smoking people with stable asthma were enrolled in this study.All patients underwent blood ollction and pulmonary function tests.The associations between serum NGAL levels and clinical parameters were analyzed retrospectively.Serum NGAL levels in patients with asthma and obstructive ventilatory defect were higher than those in patients with asthma without obstructive ventilatory defect(76.4±51.4 ng/mL vs.39.3±27.4 ng/mL,P=0.0019).Serum NGAL levels were correlated with forced expired flow at 50%of vital capacity%predicted and forced expired flow at 75%of vital capacity%predicted(r=-0.3373,P=0.0078 and r=0.2900,P=0.0234,respectively).Results of a multiple regression analysis demonstrated that serum NGAL level was independently associated with obstructive ventilatory defect.Serum NGAL levels were elevated in patients with asthma and obstructive ventilatory defect.NGAL may be involved in airway remodeling possibly mediated by neutrophilic inflammation in asthma. | Junichiro Kawagoe Yuta Kono Yuki Togashi Mayuko Ishiwari Kazutoshi Toriyama Chika Yajima Hideaki Nakayama Satoshi Kasagi Shinji Abe Yasuhiro Setoguchi | 2021 | Current Medical Science2021，41，2： | 5 |
| 3 | Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency显示文摘Background: Leptin has a strong relation to important traits in animal production, such as carcass composition,feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus.In this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake(DMI) and average daily gain(ADG) of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake(RFI) and select 20 animals for the high feed efficient(LRFI) and 20 for the low feed efficient(HRFI) groups. Blood samples were collected on d 56 and at slaughter(80 d) to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression levels.Results: DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness,as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter(P = 0.0049). Gene expression of leptin were greater in LRFI animals(P = 0.0022) in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene expression.Conclusion: These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake. | Lúcio Flávio Macedo Mota Cristina Moreira Bonafé Pamela Almeida Alexandre Miguel Henrique Santana Francisco JoséNovais Erika Toriyama Aldrin Vieira Pires Saulo da Luz Silva Paulo Roberto Leme JoséBento Sterman Ferraz Heidge Fukumasu | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 3 |
| 4 | A case of intrahepatic clear cell cholangiocarcinoma显示文摘Intrahepatic clear cell cholangiocarcinoma is very rareonly 8 cases have been reported.A 56-year-old Japanese man with chronic hepatitis B infection was diagnosed with a 2.2 cm hepatocellular carcinoma on imaging,and hepatic segmentectomy was performed.Histopathologically,the tumor cells had copious clear cytoplasm and formed glandular structures or solid nests.These pathological findings suggested the tumor was a clear cell variant of intrahepatic cholangiocarcinoma.Particular stains and radiological images suggested that the cause of the clear cell change had been glycogen,not mucin nor lipid.On immunohistochemical staining,cytokeratin(CK)7 and CK19 were positive,whereas CK20 was negative.Vimentin was detected on the cell membranes,and CD56 was focally positive.The patient was given adjuvant chemotherapy and is currently free from the tumor 7 mo postoperatively.Careful follow-up with adequate postoperative supplementary chemotherapy is necessary because the characteristics of this type of tumor are unknown. | Eo Toriyama Atsushi Nanashima Hideyuki Hayashi Kuniko Abe Naoe Kinoshita Shunsuke Yuge Takeshi Nagayasu Masataka Uetani Tomayoshi Hayashi | 2010 | World Journal of Gastroenterology2010，16，20： | 2 |
| 5 | Expression of midkine in normal and burn sites of rat skin 显示文摘 | Iwashita N Muramatsu H Toriyama K | 1999 | Bums1999，25，2： | 1 |
| 6 | Cell suspension and protoplast cul- ture in rice显示文摘 | Toriyama K Hinata K | 1985 | Plant Science1985，41，3： | 1 |
| 7 | Scoring sys tern for the preoperative evaluation of metastatic spine tumor prognosis显示文摘 | Tokuhashi Y Matsuzaki H Toriyama S | 1990 | Spine1990，15，： | 1 |
| 8 | Brachial-ankle pulse wave velocity predicts increase in blood pressure and onset of hypertension显示文摘 | Takase H Dohi Y Toriyama T | 2011 | American Journal of Hypertension2011，24，： | 1 |
| 9 | Intraoperative regional and functional thermography during resection of cerebral arterio-venous malformation显示文摘 | Okudera H Kobayashi S Toriyama T | 1994 | Neurosurgery1994，34，6： | 1 |
| 10 | Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infectfon显示文摘 | Ohata K Hamasaki K Toriyama K | 2003 | Cancer2003，97，12： | 1 |
| 11 | Preparation of high fracture toughness alumina sintered bodies from Bayer aluminum hydroxide 显示文摘 | YOSHIZAWA Y TORIYAMA M KANZAKI S | 1998 | Journal of the Ceramic Society of Japan1998，106，12： | 1 |
| 12 | Development of miniaturized 6-axis accelerometer utilizing piezoresisfive sensing elements显示文摘 | Dzung Viet Dao Toshiyuki Toriyama | 2007 | Sensors and Actuators A:Physical2007，134，2： | 1 |
| 13 | Scoring system for the preoperative evaluation of metastatic spine tumor prognosis 显示文摘 | Tokuhashi Y Matsuzaki H Toriyama S | 1990 | Spine1990，15，11： | 1 |
| 14 | De novo adipogenesis in mice at the site of injection of basement membrane and basic fibroblast growth factor显示文摘 | Kawaguchi N Toriyama K Nicodemou-Lena E | 1998 | Proc Natl Acad Sci1998，95，： | 1 |
| 15 | Rice stripe virus: prototype of a new group of viruses that replicate in plants and insects显示文摘 | Toriyama S | 1986 | Microbiological Sciences1986，3，11： | 1 |
| 16 | Endogenous adipoeyte precursor cells for regenerative soft-tissue engineering显示文摘 | Toriyama K Kawaguchi N Kitoh J | 2002 | Tissue Eng2002，8，： | 1 |
| 17 | Simlimus- eluting stent vs everolimus-eluting stent for coronary intervention in patients on chronic hemodialysis 显示文摘 | SAKAKIBARA T ISHII H TORIYAMA T | 2011 | Circ J2011，120，7： | 1 |
| 18 | Trangsgenic rice plants after direct gene transfer into protoplasts显示文摘 | Toriyama K Arimoto Y Uchimiya H | 1988 | Bio/Technology1988，6，： | 1 |
| 19 | Circulating concentrations of cardiac proteins indicate the severity of congestive heart failure 显示文摘 | Goto T Takase H Toriyama T Sugiura T Sato K Ueda R | 2003 | Heart2003，89，11： | 1 |
| 20 | Very rapid densification of nanometer silicon carbide powder by pulse electric current sintering显示文摘 | ZHOU Y HIRAO K TORIYAMA M TANAKA H | 2000 | J Am Ceram Soc2000，83，3： | 1 |
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