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| 1 | Pharmacomicrobiomics: a novel route towards personalized medicine?显示文摘在药反应的内部个人的异质是影响病人幸福并且在社会水平上提出庞大的临床、金融的负担的一个严重问题。Pharmacogenomics 在关于药反应可变性或药毒性的对单个基因背景的影响的研究的最前线,并且最近,内脏 microbiome,也被称为第二个染色体,在这个方面作为一个重要播放器被认出了。而且, microbiome 是为由于机会改进药功效和安全操作它的作文的一个很吸引人的目标。Pharmacomicrobiomics 是调查 microbiome 变化和药反应和布置(吸收,分发,新陈代谢和排泄) 的相互影响的一个新兴的领域。在这评论,我们提供历史的概述并且在在内脏 microbiome,主人和药之间的复杂相互作用上检验当前的最先进的知识。我们主张那联合 pharmacogenomics 和 pharmacomicrobiomics 将为在个性化的药做主要进展提供一个重要基础。 | Marwah Doestzada Arnau Vich Vila Alexandra Zhernakova Debby P.Y. Koonen Rinse K. Weersma Daan J. TOUW Folkert Kuipers Cisca Wijmenga Jingyuan Fu | 2018 | Protein & Cell2018，9，5： | 7 |
| 2 | Ibuprofen pharmacokinetics in preterm infants with patent ductus arteriosus显示文摘 | Van Overmeire B Touw D Schepens PJ | 2001 | Clin Pharmacol Ther2001，70，4： | 1 |
| 3 | N-acetylcysteine and hemodialysis treatment of a severe case of methyl ethyl ketone peroxide intoxication显示文摘 | van Enckevort CC Touw DJ Vleming LJ | 2008 | Clin Toxicol2008，46，： | 1 |
| 4 | Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders显示文摘 | Touw I P van de Geijn G J | 2007 | Front Biosci2007，12，： | 1 |
| 5 | A comparison of the acid-inhibitory effects of esomeprazole and rabeprazole in relation to pharmacokinetics and CYP2C19 poly- morphism显示文摘 | Hunfeld NG Touw DJ Mathot RA | 2012 | Aliment Pharmacol Ther2012，35，7： | 1 |
| 6 | Epigenetic regulation of Foxp3 expressi on in regulatory T cells by DNA methylation 显示文摘 | LAL G ZHANG N VAN DER TOUW W | 2009 | J Immunol2009，182，1： | 1 |
| 7 | Signaling through C5a receptorand C3a receptor diminishes function of murine natural regulatory T cells显示文摘 | Kwan WH van der Touw W Paz Artal E | 2013 | J Exp Med2013，210，2： | 1 |
| 8 | G-CSF and its receptor in myeloid malignancy显示文摘 | Beekman R Touw IP | 2010 | Blood2010，115，25： | 1 |
| 9 | Bayesian estimation of mixed Weibull distributions显示文摘 | TOUW A E | 2009 | Reliability Engineering & System Safety2009，94，2： | 1 |
| 10 | Signaling mechanismsof cytokine receptors and their perturbances in disease显示文摘 | Touw IP De Koning JP Ward AC | 2000 | MolCell Endocrinol2000，160，12： | 1 |
| 11 | Pharmacokinetics of aerosolized tobramycin in adult patients with cystic fibrosis显示文摘 | Touw DJ Jacobs FA Brimicome RW | 1997 | Antimicrob Agents Chemother1997，41，： | 1 |
| 12 | Comparative pharmacokinetics of the earbapenems:clinical implications显示文摘 | Mouton JW Touw DJ Horrevorts AM | 2000 | Clin Pharmacokinetics2000，39，： | 1 |
| 13 | Ibuprofen phar-macokinetics in preterm infants with patent ductus arteriosus显示文摘 | Van Overmeire B Touw D Schepens PJ | 2001 | Clin Pharmacol Ther2001，70，4： | 1 |
| 14 | A comparison of the acid-inhibitory effects of esomeprazole and rabeprazole in relation to pharmacokinetics and CYP 2C 19 polymorphism显示文摘 | Hunfeld NG Touw D J Mathot RA | 2012 | Aliment Pharmacol Ther2012，35，7： | 1 |
| 15 | Neuralmechanismsinhypertension显示文摘 | BrodyMJ HaywoodJR Touw KB | 1980 | AnnRevPhysiol1980，42，44： | 1 |
| 16 | Bayesian estimation of mixed Weibull distribu- tions 显示文摘 | Anduin E Touw | 2009 | Reliability Engineering & System Safety2009，94，： | 1 |
| 17 | G-CSF and its receptor in myeloid malignancy 显示文摘 | BEEKMAN R Touw I P | 2010 | Blood2010，115，25： | 1 |
| 18 | The Jak-Stat pathway in normal and perturbed hematopoiesis 显示文摘 | Ward AC Touw I Yoshimura A | 2000 | Blood2000，95，1： | 1 |
| 19 | DC-SIGN(+)Macrophages Control the Induction of Transplantation Tolerance显示文摘 | Conde P Rodriguez M van der Touw W | 2015 | Immunity2015，42，6： | 1 |
| 20 | A comparison of the acid-inhibitory effects of esomeprazole and rabe- prazole in relation to pharmacokinetics and CYP2C19 polymorphism 显示文摘 | Hunfeld NG Touw DJ Mathot RA | 2012 | Aliment Pharmacol Ther2012，35，7： | 1 |
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