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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Aspirin resistance显示文摘 | TRAN H A ANAND S S HANKEY G J | 2007 | Thromb Res2007，120，3： | 1 |
| 3 | Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a) 显示文摘 | Brunet A Park J Tran H | 2001 | Mol Cell Biol2001，21，3： | 1 |
| 4 | 查看详情显示文摘 | Cole A C Jensen J L Ntai I Tran K L T Weaver K J Forbes D C Davis J H Jr | | 0，，： | 1 |
| 5 | Deep venous thrombosis in patients with hematological malignancies after peripherally inserted central venous catheters显示文摘 | Tran H Arellano M Chamsuddin A | 2010 | Leuk Lymphoma2010，51，8： | 1 |
| 6 | Potential benefits of alisldrea beyond blood pressare reductlon显示文摘 | Weinaub HS Tran H Schwartmi A | 2011 | Cardiol P ev2011，19，2： | 1 |
| 7 | 显示文摘 | Nguyen H Tran Gary R Dennis a Adriyan S | 2005 | Journal of Colloid and Interface Science2005，290，： | 1 |
| 8 | Grain growth, phase evolution and properties of NbC carbide-doped WC-10AISI304 hardmetals produced by pseudo hot isostatic pressing显示文摘 | TRAN B T ZUHAILAWATI H AHMAD Z A ISHIHARA K N | 2012 | Journal of Alloys and Compounds2012，552，： | 1 |
| 9 | Laboratory diagnosis and surveillance of human respiratory viruses by PCR in Victoria, Australia, 2002-2003 显示文摘 | Druce J Tran T Kelly H Kaye M Chibo D Kostecki R Amiri A Catton M Birch C | 2005 | J Med Virol2005，75，1： | 1 |
| 10 | Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai,China显示文摘 | Wang M G Tran J H Jacoby G A | 2003 | Antimicrob Agents Chemother2003，47，7： | 1 |
| 11 | Plasmid mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China显示文摘 | Wang M Tran J H Jacoby G A | 2003 | Antimicrob Agents Chemother2003，47，7： | 1 |
| 12 | Multiwavelength Raman-fiber-laser-based long-distance remote sensor for simultaneous measurement of strain and temperature显示文摘 | HAN Y G TRAN T V A KIM S H | 2005 | Optics Letters2005，30，11： | 1 |
| 13 | Sintering characteristics and properties of WC-10AISI304 (stainless steel) hardmetals with added graphit显示文摘 | TRAN B T ZUHAILAWATI H AHMAD Z A ISHIHARA K N | 2014 | Materials Science and Engineering A2014，605，： | 1 |
| 14 | Alcohol dehydrogenase and catalase content in perinatal infant and adult livers: Potential influence on neonatal alcohol metabolism 显示文摘 | Tran M N Wu A H B Hill D W | 2007 | Toxicol Lett2007，169，3： | 1 |
| 15 | Mechanism of plasmid-mediated quinolone resistance显示文摘 | TRAN J H JACOBY G A | 2002 | Proc Natl Acad Sci USA2002，99，8： | 1 |
| 16 | Role of the cyclic lipopeptide massetolide A in biological control of Phytophthora infestans and in colonization of tomato plants by Pseudomonas fluorescens显示文摘 | Tran H Ficke A Asiimwe T | 2007 | New Phytologist2007，175，4： | 1 |
| 17 | Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China显示文摘 | Wang M Tran J H Jacoby G A | 2003 | Antimicrob Agents Chemother2003，47，7： | 1 |
| 18 | Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China显示文摘 | WANG M TRAN J H JACOBY G A | 2003 | Antimicrob Agents Chemother2003，47，7： | 1 |
| 19 | Architecture of the pulmonary veins:relevance to radiofrequency ablation显示文摘 | Ho S Y Cabrera J A Tran V H | | 0，，03： | 1 |
| 20 | DNA repair pathway stimulated by the forkhead transcription factor FoxO3a through the Gadd45protein显示文摘 | Tran H Brunet A Grenier JM | 2002 | Science2002，296，5567： | 1 |
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