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| 1 | Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer显示文摘AIM: To examine the expression of Sph K1, an oncogenic kinase that produces sphingosine 1-phosphate(S1P), and its correlation with the expression of LPAR2, a major lysophosphatidic acid(LPA) receptor overexpressed in various cancers, in human colorectal cancer.METHODS: Real-time reverse-transcription polymerase chain reaction was used to measure the m RNA expression of Sph K1, LPAR2, and the three major S1 P receptors in 27 colorectal cancer samples and corresponding normal tissue samples. We also examined the correlation between the expression of Sph K1 and LPAR2.RESULTS: C o l o r e c t a l c a n c e r t i s s u e i n 2 2 o f 2 7 patients had higher levels of Sph K1 m RNA than in normal tissue. In two-thirds of the samples, Sph K1 m RNA expression was more than two-fold higher than in normal tissue. Consistent with previous reports, LPAR2 m RNA expression in 20 of 27 colorectal cancer tissue samples was higher compared to normal tissue samples. Expression profiles of all three major S1 P receptors, S1PR1, S1PR2, and S1PR3, varied without any trend, with no significant difference in expression between cancer and normal tissues. A highly significant positive correlation was found between Sph K1 and LPAR2 expression [Pearson's correlation coefficient(r) = 0.784 and P < 0.01]. The m RNA levels of Sph K1 and LPAR2 did not correlate with TNM stage.CONCLUSION: Our findings suggest that S1 P andLPA may play important roles in the development ofcolorectal cancer via the upregulation of Sph K1 andLPAR2, both of which could serve as new therapeutictargets in the treatment of colorectal cancer. | Dai Shida Satoru Inoue Yuki Yoshida Atsushi Kodaka Tsutomu Tsuji Makoto Tsuiji | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 2 | Identification of clones of ginbuna Carassius langsdorfii by DNA fingerprint- ing and isozyme pattern显示文摘 | Dong S Taniguchi N Tsuiji S | 1996 | Nippon Suisan Gakkai- shi1996，62，5： | 1 |
| 3 | Identification of clones of ginbuna Carassius langsdorfii by DNA fingerprinting and isozyme pattern显示文摘 | DONG S TANIGUCHI N TSUIJI S | 1996 | Bulletin of the Japanese Society of Scientific Fisheries1996，62，5： | 1 |
| 4 | Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell-cell adhesion 显示文摘 | Tsuiji I-I Takasaki S Sakamoto M | 2003 | Glycobiology2003，13，7： | 1 |
| 5 | Inhibitory effect of curcumin on uterine leiomyoma cell proliferation显示文摘 | Tsuiji K Takeda T Li B | 2011 | Gynecol Endocrinol2011，27，7： | 1 |
| 6 | Competition between a noncoding exon and introns : Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1 显示文摘 | Tsuiji H Yoshimoto R Hasegawa Y | 2011 | Genes Cells2011，16，5： | 1 |
| 7 | Aberrant O-glycosylation inhibits stable expressionof dysadherin, a carcinoma-associated antigen, and facilitates cell-cell adhesion 显示文摘 | Tsuiji H Takasaki S Sakamoto M | 2003 | Glycobiology2003，13，7： | 1 |
| 8 | Autoreaetivity in human IgG ^+ memory B ceils显示文摘 | Tiller T Tsuiji M Yurasov S | 2007 | Immunity2007，26，2： | 1 |
| 9 | Terminal Sliding Mode Control of Second-Order Nonlinear Uncertain Systems 显示文摘 | Park K B Tsuiji T | 1999 | International Journal of Robust and Nonlinear Control1999，9，11： | 1 |
| 10 | Autoreactivity in human IgG + memory B cells 显示文摘 | Tiller T Tsuiji M Yurasov S | 2007 | Immunity2007，26，2： | 1 |
| 11 | Aberrant Oglycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell adhesion 显示文摘 | TSUIJI H TAKASAKI S SAKAMOTO M | 2003 | Glycobiology2003，13，7： | 1 |
| 12 | Free vibration analysis of curved and twisted cylindrical thin panels显示文摘 | Hu X X Tsuiji T | 1999 | J Sound Vib1999，219，： | 1 |
| 13 | Terminal sliding mode control of second-order nonlinear uncertain systems显示文摘 | Park K B Tsuiji T | 1999 | International Journal of Robust and Nonlinear Control1999，9，11： | 1 |
| 14 | Terminal sliding mode control of second--or- der nonlinear uncertain systems 显示文摘 | Park K B Tsuiji T | 1999 | International Journal of Ro- bust and Nonlinear Control1999，9，11： | 1 |
| 15 | Persistent expression of autoantibodies in SLE patients in remission显示文摘 | YURASOV S TILLER T TSUIJI M | 2006 | J Exp Med2006，203，10： | 1 |
| 16 | Terminal sliding mode conlrol of second-order nonlinear uncertain systems 显示文摘 | PARK B TSUIJI T | 1999 | International Journal of Robust and Nonlinear Control1999，9，11： | 1 |
| 17 | Terminal sliding mode of second-order nonlinear uncertain system显示文摘 | Park K B Tsuiji T | 1999 | International Journal of Robust and Nonlinear Control1999，9，11： | 1 |
| 18 | Terminal sliding mode control ofsecond-order nonlinear uncertain systems显示文摘 | Park K B Tsuiji T | 1999 | Inter-national Journal of Robust and Nonlinear Control1999，9，11： | 1 |
| 19 | Terminal sliding mode control of second-order nonlinear uncertain systems显示文摘 | Park K B Tsuiji T | 1999 | International Journal of Robust and Nonlinear Control1999，9，11： | 1 |
| 20 | Antiprolifera-tive effect of adiponectin on rat uterine leiomyoma ELT-3 cells显示文摘 | WAKABAYASHI A TAKEDA T TSUIJI K | 2011 | Gynecol Endocrinol2011，27，1： | 1 |
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