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| 1 | An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure显示文摘Acute hepatic failure (AHF) is a severe liver injury accompanied by hepatic encephalopathy which causes multiorgan failure with an extremely high mortality rate, even if intensive care is provided. Management of severe AHF continues to be one of the most challenging problems in clinical medicine. Liver transplantation has been shown to be the most effective therapy, but the procedure is limited by shortage of donor organs. Although a number of clinical trials testing different liver assist devices are under way, these systems alone have no significant effect on patient survival and are only regarded as a useful approach to bridge patients with AHF to liver transplantation. As a result, reproducible experimental animal models resembling the clinical conditions are still needed. The three main approaches used to create an animal model for AHF are: surgical procedures, toxic liver injury and infective procedures. Most common models are based on surgical techniques (total/partial hepatectomy, complete/transient devascularization) or the use of hepatotoxic drugs (acetaminophen, galactosamine, thioacetamide, and others), and very few satisfactory viral models are available. We have recently developed a viral model of AHF by means of the inoculation of rabbits with the virus of rabbit hemorrhagic disease. This model displays biochemical and histological characteristics, and clinical features that resemble those in human AHF. In the present article an overview is given of the most widely used animal models of AHF, and their main advantages and disadvantages are reviewed. | María Jesús Tuón Marcelino Alvarez Jesús M Culebras Javier González-Gallego | 2009 | World Journal of Gastroenterology2009，15，25： | 29 |
| 2 | 纳米-微米颗粒增强复合钎料研究最新进展显示文摘综合评论含纳米-微米颗粒无铅钎料研究与应用现状,分别介绍国内外针对金属、化合物、陶瓷、碳纳米管及高分子几种颗粒对无铅钎料性能的影响。主要从无铅钎料内部组织、界面组织、熔化特性、润湿性、力学性能和蠕变性能几方面探讨颗粒对钎料组织和性能的影响。同时简述颗粒增强的无铅钎料在应用过程中出现的问题及相应的解决措施,并对颗粒增强无铅钎料的发展趋势进行分析和展望。 | 张亮 Tu K N 孙磊 郭永环 何成文 | 2015 | 中南大学学报(自然科学版)2015，46，1： | 21 |
| 3 | 时效对SnAgCu/SnAgCu-TiO_2焊点界面与性能影响显示文摘研究了SnAgCu与SnAgCu-TiO2两种无铅钎料与铜基板之间的界面反应,研究其在140℃时效过程中的生长行为及力学性能变化.结果表明,焊后两种钎料对应界面层为Cu6Sn5相,经过140℃时效,界面层厚度随着时效时间的增加而增加.发现金属间化合物层厚度和时效时间的平方根成正比例关系.当时效时间为300 h时,界面层出现Cu3Sn相,发现纳米TiO2颗粒对界面金属间化合物层厚度有明显的抑制作用.同时对焊点力学性能分析,在时效过程中焊点平均拉伸力明显下降,SnAgCu-TiO2焊点的力学性能明显优于SnAgCu焊点. | 张亮 Tu K N 郭永环 何成文 张剑 | 2013 | 焊接学报2013，34，8： | 17 |
| 4 | Sn-0.3Ag-0.7Cu-xSb无铅钎料润湿性显示文摘研究了微量Sb元素对Sn-0.3Ag-0.7Cu无铅钎料润湿性的影响,采用润湿平衡法探讨了Sn-0.3Ag-0.7Cu-x Sb钎料在不同氛围和不同钎剂条件下的润湿性能.结果表明,微量的Sb元素可以显著提高Sn-0.3Ag-0.7Cu无铅钎料润湿性.在氮气氛围条件下,Sn-0.3Ag-0.7Cu-x Sb钎料的润湿性得到显著改善,主要基于氮气氛围减小熔融钎料的氧化.辅助不同的钎剂,钎料的润湿性差异较大,选择合适的钎剂可以明显提高Sn-0.3Ag-0.7Cu-x Sb钎料的润湿性. | 张亮 Tu K N 孙磊 郭永环 何成文 | 2015 | 焊接学报2015，36，1： | 7 |
| 5 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 6 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 7 | 显示文摘 | Zeng K Tu K N | 2002 | Mater Sci Eng R2002，38，： | 2 |
| 8 | Six cases of reliability study of Pbfree solder joints in electronic packaging technology 显示文摘 | Zeng K Tu K N | 2002 | Materials Science and Engineering A2002，38，1： | 2 |
| 9 | Lnl-x,SrxCoO3, CoO3(Ln = Sm,Dy)for the electrode of solid oxide fuel cells显示文摘 | Tu H Y Takeda Y Imanishi N | 1997 | Solid State lonics1997，100，： | 1 |
| 10 | Ln1-xSrxCoO3 (Ln = Sm,Dy) for the electrode of solid oxide fuel cells显示文摘 | Tu H Y Takeda Y Imanishi N | 1997 | Solid State Ionics1997，100，： | 1 |
| 11 | Physics and materials challenges for lead-free solders 显示文摘 | Tu K N Gusak A M Li M | 2003 | Journal of Applied Physics2003，93，3： | 1 |
| 12 | Microstructure,chemical and tribological investigations of MoxW1-xSy co-sputtered composite films显示文摘 | YIN G L HUANG P H YU Z HE D N TU J P | 2006 | Tribology Letters2006，22，1： | 1 |
| 13 | Roundness modeling of machined parts for tolerance analysis显示文摘 | CHO N TU J | 2001 | Precision Engineering2001，25，1： | 1 |
| 14 | Biomagnification of trace elements in the aquatic food web in the Mekong Delta, South Vietnam using stable carbon and nitrogen isotope analysis显示文摘 | Ikemoto T Tu N PC Okuda N | 2008 | Archives of Environmental Contamination and Toxicology2008，54，： | 1 |
| 15 | Effect of surface treatment on interfacial strength between bamboo fiber arld PP resin 显示文摘 | TUING N H YAMAMOTO H MATSUOKA T | 2004 | JSME International Journal Series A: Mechanics and Material Engineering2004，47，4： | 1 |
| 16 | Tin whiskers studied by syn-chrotron radiation scanning X-ray micro-diffraction显示文摘 | Choi W J Lee T Y Tu K N | 2003 | ActaMaterialia2003，51，： | 1 |
| 17 | 显示文摘 | Zeng K Tu K N | 2002 | Mater Sci Eng R2002，38，2： | 1 |
| 18 | Tin whiskers studied by synchrotron radiation scanning X-ray micro-diffraction显示文摘 | LEE T Y TU K N | 2003 | Acta Materialia2003，51，20： | 1 |
| 19 | Mechanism of electromigration induced failure in flip chip solder joints with a 10-1~m- thick Cu under-bump metallization 显示文摘 | Nab J W Chen K Tu K N | 2007 | Journal of Materi- al Research2007，22，3： | 1 |
| 20 | 显示文摘 | Sze Tu L Dehghani F Foster N R | 2002 | Powder Technology2002，126，： | 1 |
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