|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of resveratrol and methylprednisolone on biochemical,neurobehavioral and histopathological recovery after experimental spinal cord injury显示文摘瞄准:在损害(SCI ) 在老鼠建模的试验性的脊髓调查 resveratrol 的 neuroprotective 效果。方法:男 Wistar 白鼠称 200-250 g 被使随机化进六个组。重量落下损伤为 SCI 被执行。组 1 独自经历了椎板切除术。组 2 经历了 SCI 跟随的椎板切除术。3, 4, 5,和 6 经历了的组 SCI 跟随并且收到了 resveratrol (100 mg/kg ) 的椎板切除术,甲基氢化尼松(MP )(30 mg/kg ) ,加 MP (30 mg/kg ) 的 resveratrol (100 mg/kg ) ,和乙醇(2%) 分别地。老鼠为生物化学的分析被划分成二亚群(在外科以后在 24 点杀死了 h ) 并且为 neurobehavioral 和组织病理学说的评估(在外科以后在 6 点杀死了星期) 。在外科以后的 Posttraumatic 神经病学的恢复每周被记录。结果:3 和 5 揭示了的组显著地比组织 4 降低 malon-dialdehyde,氮的氧化物,黄嘌呤氧化酶,和更高的谷胱甘肽层次(P<0.05 ) 。神经病学的恢复率显著地更好在比组织 4 组织 3 和 5 (P<0.05 ) 。当针的损伤尺寸比率被比较时,在治疗组之间没有有效差量。结论:Resveratrol 处理比 MP 处理在损伤的尖锐阶段揭示了更好生物化学的恢复。尽管 resveratrol 和联合处理比 MP 处理揭示了更好的 neurobehavioral 恢复;resveratrol, MP,和联合处理形式在实验的最后的阶段在一样的水平改进了组织病理学说的恢复。当每药有行动的不同抗氧化的机制,与 MP 包含 resveratrol 和不同剂量联合的不同剂量的未来研究能答应更好的结果。 | Ozkan ARIES Suleyman CAYLI Eyup ALTINOZ Iclal GURSES Neslihan YUCEL Ayhan KOCAK Saim YOLOGLU Yusuf TURKOZ | 2006 | Acta Pharmacologica Sinica2006，27，10： | 18 |
| 2 | Cytoprotective effects of amifostine,ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats显示文摘AIM:To investigate the potential role of oxidative stress and the possible therapeutic effects of N-acetyl cysteine(NAC),amifostine(AMF)and ascorbic acid(ASC)in methotrexate(MTX)-induced hepatotoxicity.METHODS:An MTX-induced hepatotoxicity model was established in 44 male Sprague Dawley rats by administration of a single intraperitoneal injection of20 mg/kg MTX.Eleven of the rats were left untreated(Model group;n=11),and the remaining rats were treated with a 7-d course of 50 mg/kg per day NAC (MTX+NAC group;n=11),50 mg/kg per single dose AMF(MTX+AMF group;n=11),or 10 mg/kg per day ASC(MTX+ASC group;n=11).Eleven rats that received no MTX and no treatments served as the negative control group.Structural and functional changes related to MTX-and the various treatments were assessed by histopathological analysis of liver tissues and biochemical assays of malondialdehyde(MDA),superoxide dismutase(SOD),catalase,glutathione(GSH)and xanthine oxidase activities and of serum levels of aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase and total bilirubin.RESULTS:Exposure to MTX caused structural and functional hepatotoxicity,as evidenced by significantly worse histopathological scores[median(range)injury score:control group:1(0-3)vs 7(6-9),P=0.001]and significantly higher MDA activity[409(352-466)nmol/g vs 455.5(419-516)nmol/g,P<0.05].The extent of MTX-induced perturbation of both parameters was reduced by all three cytoprotective agents,but only the reduction in hepatotoxicity scores reached statistical significance[4(3-6)for NAC,4.5(3-5)for AMF and 6(5-6)for ASC;P=0.001,P=0.001 and P<0.005vs model group respectively].Exposure to MTX also caused a significant reduction in the activities of GSH and SOD antioxidants in liver tissues[control group:3.02(2.85-3.43)μmol/g and 71.78(61.88-97.81)U/g vs model group:2.52(2.07-3.34)μmol/g and 61.46(58.27-67.75)U/g,P<0.05];however,only the NAC treatment provided significant increases in these antioxidant enzyme activities[3.22(2.54-3.62)μmol/g and 69.22(61.13-100.88)U/g,P<0.05 and P<0.01vs model group respectively].CONCLUSION:MTX-induced structural and functional damage to hepatic tissues in rats may involve oxidative stress,and cytoprotective agents(NAC>AMF>ASC)may alleviate MTX hepatotoxicity. | Sami Akbulut Hulya Elbe Cengiz Eris Zumrut Dogan Gulten Toprak Emrah Otan Erman Erdemli Yusuf Turkoz | 2014 | World Journal of Gastroenterology2014，20，29： | 3 |
| 3 | Melatonin ameliorates cerebral vasospasm after experimental subarachnoidal haemorrhage cot recting imbalance of nitric oxide levels in rats 显示文摘 | Aladag MA Turkoz Y Parlakpinar H | 2009 | Neurochem Res2009，34，11： | 1 |
| 4 | Risk factors of na- sopharyngeal carcinoma in Turkey-an epidemiological survey of the Anatolian Society of Medical Oncology 显示文摘 | Turkoz FP Celenkoglu G Dogu GG | 2011 | Asian Pac J Cancer Prev2011，1201，： | 1 |
| 5 | Oral clonidine premedicationdoes not reduce postoperative vomiting in children undergoing strabis- mus surgery显示文摘 | Gulhas N Turkoz A Durmus M | 2003 | Acta Anaesthessiol Scond2003，47，1： | 1 |
| 6 | New current-mode current-controlled universal filter with single input and three outputs显示文摘 | MINAEI S TURKOZ S | 2001 | International Journal of Electronics2001，88，3： | 1 |
| 7 | Effect of NG-Nitro L-arginine and corlicosteroids on aquenos humor levels og nitric oxide and cytokines after cataract surgery显示文摘 | Er H Gunfuz A Turkoz Y | 1999 | J Cataract Refract Surg1999，25，： | 1 |
| 8 | Paliperidone ER and oral risperidone in patients with schizophrenia: a comparative database analysis 显示文摘 | Turkoz I Bossie CA Lindenmayer JP | 2011 | BMC Psychiatry2011，11，4： | 1 |
| 9 | The protective effects of N-acetyl-L-cysteine and epigallocatechin-3-gallate on electric field- induced hepatic oxidative stress 显示文摘 | Guler G Turkozer Z Tomruk A | 2008 | Int J Radiat Biol2008，84，： | 1 |
| 10 | New Current-Mode Lowpass,Bandpass and Highpass Filters Employing CCCIIs Circuits and Systems,MWSCAS 2001显示文摘 | MINAEI S CICEKOGLU O KUNTMAN H TURKOZ S | 2001 | Proceedings of the 44th IEEE 2001 Midwest Symposium on2001，，1： | 1 |
| 11 | Direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia显示文摘 | Turkoz I Bossie CA Dirks B | 2008 | Neuropsychiatr Dis Treat2008，4，5： | 1 |
| 12 | Efficacy and safty of paliperidone extended - release in schizophrenia patients with prominent affective symptoms显示文摘 | CANUSO CM TURKOZ I SHEEHAN JJ | 2010 | JAffect Disord2010，120，13： | 1 |
| 13 | Protective effects of melatonin on myocardial ischemia-reperfusion induced infarct size and oxidative changes显示文摘 | Sahna E Parlakpinar H Turkoz Y | 2005 | Physiol Res2005，54，5： | 1 |
| 14 | Increased nitric oxide production in the spermatic vein of patients with varicocele显示文摘 | Ozbek E Turkoz Y Gokdeniz R Davarci M Ozugurlu F | 2000 | Eur Urol2000，37，2： | 1 |
| 15 | Paliperidone extended-release for schizophrenia:effects on symptoms and functioning in acutely ill patients with negative显示文摘 | Canuso C M Bossie C A Turkoz I | 2009 | Symptoms Schizophr Res2009，113，1： | 1 |
| 16 | Efficacy and safety of paliperidone extended release in schizophrenia patients with prominent affective symptoms显示文摘 | Canuso CM Turkoz I Sheehan JJ | 2010 | J Affect Disord2010，120，13： | 1 |
| 17 | Epidermal Notchl loss promotes skin tumorigenesis by impacting the stromal microenvironment显示文摘 | Demehri S Turkoz A Kopan R | 2009 | Cancer Cell2009，16，： | 1 |
| 18 | Treatment ef- fects of the Forsus fatigue resistant device used with miniscrew anchorage显示文摘 | Asian BI Kucukkaraea E Turkoz C | 2014 | Angle Orthod2014，84，1： | 1 |
| 19 | Paliperidone extended -release for schizophrenia: effects on symptoms and functioning in acutely ill patients with nega- tive symptoms 显示文摘 | Canuso C M Bossie C A Turkoz I | 2009 | Schizophrenia research2009，113，1： | 1 |
| 20 | Sonographic findings in ectopic cervical thymus in an infant显示文摘 | Atasoy C Turkoz E | 2001 | J Clin Ultrasound2001，29，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员