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| 1 | Clinical assessment and management of liver fibrosis in nonalcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is among the most frequent etiologies of cirrhosis worldwide,and it is associated with features of metabolic syndrome;the key factor influencing its prognosis is the progression of liver fibrosis.This review aimed to propose a practical and stepwise approach to the evaluation and management of liver fibrosis in patients with NAFLD,analyzing the currently available literature.In the assessment of NAFLD patients,it is important to identify clinical,genetic,and environmental determinants of fibrosis development and its progression.To properly detect fibrosis,it is important to take into account the available methods and their supporting scientific evidence to guide the approach and the sequential selection of the best available biochemical scores,followed by a complementary imaging study(transient elastography,magnetic resonance elastography or acoustic radiation force impulse)and finally a liver biopsy,when needed.To help with the selection of the most appropriate method a Fagan′s nomogram analysis is provided in this review,describing the diagnostic yield of each method and their post-test probability of detecting liver fibrosis.Finally,treatment should always include diet and exercise,as well as controlling the components of the metabolic syndrome,+/-vitamin E,considering the presence of sleep apnea,and when available,allocate those patients with advanced fibrosis or high risk of progression into clinical trials.The final end of this approach should be to establish an opportune diagnosis and treatment of liver fibrosis in patients with NAFLD,aiming to decrease/stop its progression and improve their prognosis. | Alejandro Campos-Murguía Astrid Ruiz-Margáin JoséA González-Regueiro Ricardo U Macías-Rodríguez | 2020 | World Journal of Gastroenterology2020，26，39： | 12 |
| 2 | Clinical scenarios for the use of S100β as a marker of hepatic encephalopathy显示文摘AIM: To evaluate the association between serum concentrations of S100β in patients with cirrhosis and the presence of low grade hepatic encephalopathy(HE).METHODS: This was a cross-sectional study. The population was categorized into four groups healthy subjects, cirrhosis without HE, cirrhosis with covert hepatic encephalopathy(CHE) and cirrhosis with overt HE. Kruskal-Wallis, Mann Whitney's U with Bonferroni adjustment Spearman correlations and area under the ROC were used as appropriate.RESULTS: A total of 61 subjects were included, 46 cirrhotic patients and 15 healthy volunteers. S100β values were different among all groups, and differences remained significant between groups 1 and 2(P < 0.001), and also between groups 2 and 3(P = 0.016), but not between groups 3 and 4. In cirrhotic patients with HE S100β was higher than in patients without HE [0.18(0.14-0.28) ng/m L vs 0.11(0.06-0.14) ng/m L, P < 0.001]. There was a close correlation between serum concentrations of S100β and psychometric hepatic encephalopathy score in patients with cirrhosis without HE compared to the patients with cirrhosis with CHE(r =-0.413, P = 0.019). ROC curve analysis yielded > 0.13 ng/m L as the best cutoff value of S100β for the diagnosis of HE(sensitivity 83.3%, specificity 63.6%).CONCLUSION: Serum concentrations of S100β are higher in patients with cirrhosis than in healthy volunteers, and are further increased in the presence of hepatic encephalopathy. The results suggest that serum biomarkers such as S100β could help in the correct characterization of incipient stages of HE. | Andrés Duarte-Rojo Astrid Ruiz-Margáin Ricardo U Macias-Rodriguez Francisco Javier Cubero José Estradas-Trujillo Rosa Ma Munoz-Fuentes Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，17： | 4 |
| 3 | Dynamic Programming for Multidimensional Stochastic Control Problems | Jin Ma Department of Mathematics,Purdue University,West Lafayette,IN 47907-1395,U S A E-mail:majin@math.purdue,eduJiongmin Yong Laboratory of Mathematics for Nonlinear Science,Department of Mathematics,and Institute of Mathematical Finance,Fudan University,Shanghai 200433,P.R.China E-mail:jyong@fudan,edu.cn | 1999 | Acta Mathematica Sinica,English Series1999，15，4： | 2 |
| 4 | S regional studies显示文摘 | JAMES W HARRINGTON Prcducer service research in U | 1995 | Professional Gecgraphier1995，47，1： | 1 |
| 5 | Polish journal of microbiology/Polskie Towarzystwo Mikrobiologow显示文摘 | Kowalska B Smolinska U Oskiera IVL First report of Serratia plymuthica causing onion bulb rot in Poland | 2011 | The Polish Society of Microbiologists2011，60，1： | 1 |
| 6 | The influence of configuration factors on cavity adaptation in compomer restorations显示文摘 | U noS T anakaT In oueS | 1999 | Dent Mater1999，18，： | 1 |
| 7 | Recyclable tertaaryphosphonium supported chiral im idazolidin^-one organocatalyst forD iels-A lder reactions显示文摘 | L in Z H L u C F Yang G C e t a l | 2013 | Catal Commun2013，35，： | 1 |
| 8 | Friction and wear properties of micro textured DLC coated surfaces in boundary lubricated sliding 显示文摘 | location in dry point frictionless Tribology - Transactions of the Pettersson U Jacobson S | 2004 | Tribology Letters2004，17，： | 1 |
| 9 | Antimicrobial suscep- tibility and coagulase gene typing of Staphylococcus aureus isolated from bovine clinical mastitis cases in Turkey显示文摘 | Guler In Ok U Gunduz K | | 0，，09： | 1 |
| 10 | MR imaging and spectroscopy of a tuber cinereum hamartoma in a pat ient with growth hormone deficiency and hypogonadotropic hypogonadism显示文摘 | Mart in DD Seeger U Ranke MB | 2003 | AJNR2003，24，： | 1 |
| 11 | E ffica cy o f early postoperativeenteral n u tritio n in supporting patients afteresophagectomy显示文摘 | Y u X B L in Q Q in X et a l | 2014 | Minerva Chir2014，69，1： | 1 |
| 12 | Characterization and biological potency of mono - to tetra-halogenated carbazoles 显示文摘 | Riddell N in U H Safe S | 2015 | Environmental Science & Technology2015，49，10： | 1 |
| 13 | AU: Willemse JL, Leurs JR, Hendriks DF显示文摘 | TI: Fast kinetic assay for the determination of procarboxypeptidase U (TAFI) in human plasma | 2005 | J Thromb Haemost2005，3，10： | 1 |
| 14 | cisplatin/vinorlbine alone in the first-line treatment of patients with epidermal growth factor receptor expressing advanced non-small-cell lung cancer 显示文摘 | Gatzemeier U RoseU R Ramlau R Cetuximab (Erbitux) in combination with cisplatin/vinorelbine vs | 2003 | Proc Am Soc Clin Oncol2003，22，： | 1 |
| 15 | Rapid automated diagnosis of diabetic peripheral neuropathy with in vivo corneal confocal mi- croscopy显示文摘 | Petropoulos IN Alam U Fadavi H | 2014 | Invest Ophthalmol Vis Sci2014，55，4： | 1 |
| 16 | S and Canada显示文摘 | Anderson M B Kanter S L Medical Education in the U | 2010 | Academic Medicine2010，85，9： | 1 |
| 17 | Silole-containing poly(silylenevinylene)s: synthesis, characterization, Aggregation- Enhanced emission, and explosive deteetion显示文摘 | Zhao Zu]in Jiang Tao Guo Yan]u | 2012 | Journal of Polymers Scienee Part A : Polymer Chemistry2012，50，1： | 1 |
| 18 | An interim report on a controlled double-blind mt:!ticenter study versus placebo 显示文摘 | Marini A Franzetii M Gios G Flauto U Arosio A Maccabruni M Ambroxol in the treatment of idiopathic respiratory dis-tress syndrome | 1987 | Respiration1987，51，1： | 1 |
| 19 | A longer look at the asymmetric dependence between hedge funds and the equity market显示文摘 | Kang B U In F Kim G | 2010 | Journal of Financial and Quantitative Analysis2010，45，3： | 1 |
| 20 | A c tiv e dam pingbasedco n tro l fo r grid -con necte d L C L -filte re d in v e rte r w ithin je c te d g rid cu rre n t feedback o n ly 显示文摘 | X u J in m in g X ie S h a o ju n Tang T in g | | IE E E Trans on In du s tria l E le c tro n ic s0，61，9： | 1 |
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