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| 1 | A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity显示文摘Arylamine N-acetyltransferase(NAT; E.C. 2.3.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation. In this process, the acetyl group transferred to the acceptor substrate produces NAT deacetylation and, in consequence, it is susceptible of degradation. Sirtuins are protein deacetylases, dependent on nicotine adenine dinucleotide,which perform post-translational modifications on cytosolic proteins. To explore possible sirtuin participation in the enzymatic activity of arylamine NATs, the expression levels of NAT1, NAT2,SIRT1 and SIRT6 in peripheral blood mononuclear cells(PBMC) from healthy subjects were examined by flow cytometry and Western blot. The in situ activity of the sirtuins on NAT enzymatic activity was analyzed by HPLC, in the presence or absence of an agonist(resveratrol) and inhibitor(nicotinamide) of sirtuins. We detected a higher percentage of positive cells for NAT2 in comparison with NAT1, and higher numbers of SIRT1t cells compared to SIRT6 in lymphocytes. In situ NAT2 activity in the presence of NAM inhibitors was higher than in the presence of its substrate, but not in the presence ofresveratrol. In contrast, the activity of NAT1 was not affected by sirtuins. These results showed that NAT2 activity might be modified by sirtuins. | Eneida Turiján-Espinoza Rául Alejandro Salazar-González Edith Elena Uresti-Rivera Gloria Estela Hernández-Hernández Montserrat Ortega-Juárez Rosa Milán Diana Portales-Pérez | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 7 |
| 2 | A tabu search algorithm for the integrated scheduling problem of container handling systems in a maritime terminal显示文摘 | Chert L Bostel N Dejax P et ul | 2007 | European Journal of Operational Research2007，181，1： | 1 |
| 3 | Energy and throughput efficient cooperative spectrum sensing in cognitive radio sensor net- works显示文摘 | EJAZ W SHAH G A UL HASAN N | 2015 | European Transactions on Emerging Telecommunication Technologies2015，26，7： | 1 |
| 4 | hybrid coatings: morphological, mechanical, investigations 显示文摘 | Karatas S Kayaman-Apohan N Demirer H et ul | | Polymers for Advanced 'l''echnolol0，，6： | 1 |
| 5 | Isolation of human tumor- - specific antibodies by selection Of an antibody phage library on melanoma ceils显示文摘 | KUPSCH J M TIDMAN N H KANG N V et ul | 1999 | Clin Cancer Res1999，5，： | 1 |
| 6 | Bioaerosol character- ization by surface-enhanced Raman spectroscopy (SERS) 显示文摘 | Sengupta A Laucks ML Dildine N et ul | 2005 | J Aerosol Sci2005，36，5： | 1 |
| 7 | IARC monographs: 40 years of evaluating carcinogenic hazards to humans 显示文摘 | PEARCE N BLAIR A VINNEIS P et ul | 2015 | Environ Health Persp2015，123，6： | 1 |
| 8 | Triggering techniques for a compact Marx generator显示文摘 | Beverly Ul R E Campbell R N | 1994 | Rev Sci lnstrurn1994，65，1： | 1 |
| 9 | Heart failure with preserved ejection fraction-unwinding the diagnosis mystique显示文摘 | Asrar Ul Hag M Mutha V Rudd N | 2014 | Am J Cardiovasc Dis2014，4，3： | 1 |
| 10 | The serologic screening for celiac disease in the general population (blood donors) and in some high-risk groups of adults (patients with autoimmune diseases, osteoporosis and infertility) in the Czech Republic显示文摘 | Z. Van?íková V. Chlumecky D. Sokol D. Horáková E. Ham?íková T. Fu?íková I. Janatková Z. Ul?ová-Gallová J. ?těpán Z. Limanová M. Dvo?ák P. Kocna D. Sánchez L. Tu?ková H. Tlaskalová-Hogenová | 2002 | Folia Microbiologica2002，，6： | 1 |
| 11 | Effect of deep brain stimulation on parkinson's nonmotor symptoms following unilateral DBS:A pilot study显示文摘 | Hwynn N Ul Haq I Malaty IA | 2011 | Parkinsons Dis2011，9，16： | 1 |
| 12 | Lin28 enhances tissue repair by reprogramming cellular metabolism 显示文摘 | Shyh-Chang N Zhu H Yvanka de Soysa T et ul | 2013 | Cell2013，155，4： | 1 |
| 13 | In Arabidopsis thaliarta, 1% of the genome codes for a novel protein family unique to plants显示文摘 | Anbourg S Boudet N Kreis M et ul | 2000 | Plant Mol Biol2000，42，4： | 1 |
| 14 | Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes:a histopathological follow-up study显示文摘 | Ekstedt M Franzén LE Mathiesen UL | 2007 | J Hepatol2007，47，1： | 1 |
| 15 | Statins but not angiotensin- converting enzyme inhibitors delay progression of aortic stenosis 显示文摘 | Rosenhek R Rader F Loho N et ul | 2004 | Circulation2004，110，10： | 1 |
| 16 | Photodegradable Hydrogels tbr Dynamic Tuning of Physical and Chemical Proper-ties显示文摘 | Kloxin A M Kasko A M Salinas C N et ul | 2009 | Science2009，324，： | 1 |
| 17 | The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigene- sis显示文摘 | Liu Y Chen N Cui X et ul | 2010 | Oneogene2010，29，44： | 1 |
| 18 | Using El Nino-southem oscillation climate data to improve food policy planning in Indonesia 显示文摘 | Naylor R Falcon W Wada N et ul | 2002 | Bulletin Indonesian Economic Studies2002，38，： | 1 |
| 19 | A t m o s p h e r i c transport a n d deposition of pesticides : A nassessment of current k n o w l e d g e 显示文摘 | V a n P ul W A J B i d l e m a n T F B r o r s t r o m - L u n d e n E etal | | W a t e r Air a n d SoilPollution 1 9 9 90，115，1： | 1 |
| 20 | Ambulatory blood pressure after therapeutic and subtherapeutie nasal continuous positive airway pressure for obstructive sleep apnoea:a randomised parallel trial 显示文摘 | Pepperell JC Ramdassingh-Dow S Crosthwaite N ct ul | 2002 | Lancet2002，359，： | 1 |
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