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| 1 | Defensin expression in chronic pouchitis in patients with ulcerative colitis or familial adenomatous polyposis coli显示文摘瞄准:当在在为家庭腺瘤息肉病关口 i (FAP ) 的 proctocolectomy 以后的病人是稀罕的时, Pouchitis 在小袋外科以后在开始的 10 年期间与 ulcerative 在多达 50% 病人在 ileoanal 小袋发展症候群。Defensins 是天生的免疫系统的主要部件并且在胃肠的微生物引起的动态平衡起一个重要作用。小袋 defensin 和 cytokine 表示与小袋发炎的状态被相关在 pouchitis 学习他们的角色。方法:有 ulcerative 和 FAP 症候群的病人在外科以后与小袋被成层进组,小袋没有或与 pouchitis。从从健康的肠或从有 ulcerative 的病人的正常终端回肠的终端回肠的活体检视用作控制。从小袋和控制的 mRNA 为 defensin 和 cytokine 表示被分析。结果:defensins 的表示在外科以后立即在所有小袋被增加,与控制的回肠相比。开始,在 ulcerative 的小袋比 FAP 小袋揭示了更高的 defensin 表示。Defensin 表示在两个耐心的组衰退了并且与 ulcerative 在病人在 pouchitis 稍微再增加了。没有 pouchitis 的 FAP 小袋有 beta-defensin hBD-1 的强壮的表示,当所有另外的 defensins 在底层留下了时。在 ulcerative 小袋的 Cytokine 表示高,当 FAP 小袋仅仅在外科以后显示出中等提高的 cytokines 时。结论:pouchitis 的开发除了 cytokines 的高表示在 ulcerative 与减少的 defensin 表示相关。在 FAP 小袋的 pouchitis 的低发生与低 cytokine 层次联合与 hBD-1 beta-defensin 的增加的表示相关。 | Karlheinz Kiehne Gabriele Brunke Franziska Wegner Tomas Banasiewicz Ulrich R F lsch Karl-Heinz Herzig | 2006 | World Journal of Gastroenterology2006，12，7： | 8 |
| 2 | Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace显示文摘 | Ulrich F?rstermann Thomas Münzel | 2006 | Circulation2006，，13： | 2 |
| 3 | Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death显示文摘 | Alexander Seiler Manuela Schneider Heidi F?rster Stephan Roth Eva K. Wirth Carsten Culmsee Nikolaus Plesnila Elisabeth Kremmer Olof R?dmark Wolfgang Wurst Georg W. Bornkamm Ulrich Schweizer Marcus Conrad | 2008 | Cell Metabolism2008，，3： | 2 |
| 4 | Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells显示文摘AIM: To present an approach for selectively killing retrovirus-infected cells that combines the toxicity of Pseudomonas exotoxin (PE) and the presence of reverse transcriptase (RT) in infected cells. METHODS: PE antisense toxin RNA has palindromic stem loops at its 5' and 3' ends enabling self-primed generation of cDNA in the presence of RT. The RT activity expressed in retrovirus-infected cells converts 'antisense-toxin-RNA' into a lethal toxin gene exclusively in these cells. RESULTS: Using cotransfection studies with PE-expressing RNAs and β-gal expressing reporter plasmids, we show that, in HepG2 and HepG2.2.15 hepatoma cells as well as in duck hepatitis B virus (DHBV) infected cells, HBV or DHBV-polymerase reverse transcribe a lethal cDNA copy of an antisense toxin RNA, which is composed of sequences complementary to a PE gene and eukaryotic transcription and translation signals. CONCLUSION: This finding may have important implications as a novel therapeutic strategy aimed at the elimination of HBV infection. | Peter Hafkemeyer Ulrich Brinkmann Elizabeth Brinkmann Ira Pastan Hubert E Blum Thomas F Baumert | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 5 | Methylprednisolone therapy in deceased donors reduces inflammation in donor liver and improves outcome after liver transplantation:a prospective randomized controlled trial显示文摘 | Kotsch K Ulrich F Reulzel-Selke A | 2008 | Ann Surg2008，248，6： | 1 |
| 6 | Biodegradable magnesium scaffolds:Part Ⅱ:peri-implant bone remodeling显示文摘 | Witte F Ulrich H Palm C | | 0，，03： | 1 |
| 7 | Biodegradable magnesium scaffolds:Part I:Appropriate inflammatory response显示文摘 | Witte F Ulrich H Rudert M | | 0，，03： | 1 |
| 8 | FDA's pediatric device consortia:National program fosters pediatric medical device development显示文摘 | Ulrich L C Joseph F D Lewis D Y | 2013 | Pediatrics2013，131，5： | 1 |
| 9 | BioID:A Multimodal Biometric Identification System显示文摘 | Robert W F Ulrich D | 2000 | IEEE Computer2000，33，2： | 1 |
| 10 | Li- pofuscin- and melanin-related fundus autofluorescence in pa- tients with ABCA 4-associated retinal dystrophies 显示文摘 | Simone K Ulrich K Bernhard HF Britta F Silke W Klaus R | 2009 | Am JOphthcdmol2009，147，8： | 1 |
| 11 | Matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with different types of scars and keloids显示文摘 | Ulrich D Ulrich F Unglaub F | 2010 | J Plast Reconstr Aesthet Surg2010，63，： | 1 |
| 12 | Matrix metalloproteinases and tissue inhibitors of meta lloproteinases in patients with different types of scars and keloids显示文摘 | Ulrich D Ulrich F Unglaub F | 2009 | J Plastic Reconstr Aesthet Surg2009，20，： | 1 |
| 13 | Accumulative phases for heavy metals in limnic sediments显示文摘 | Ulrich F?rstner | | Hydrobiologia0，，1： | 1 |
| 14 | CD437, a synthetic retinoid, induces apoptosis in human respiratory epithelial cells via caspase-independent mitochondrial and caspase-8-dependant pathways both up-regulated by JNK signaling pathway显示文摘 | Biosvieux Ulrich E Sourdeval M Marano F | 2005 | Exp Cell Res2005，307，1： | 1 |
| 15 | Evolution of thermokarst in East Siberian ice-rich permafrost: A case study显示文摘 | Morgenstern A Ulrich M Günther F | 2013 | Geomorphology2013，201，： | 1 |
| 16 | Enhancement of adipocyte differentiation by an insulin-sensitizing agent显示文摘 | Kletzien R F Clarke S D Ulrich R G | 1992 | Mol Pharmacol1992，41，： | 1 |
| 17 | Biodegradable mag nesium scaffolds:Part Ⅱ:Peri-implant bone remodeling显示文摘 | Witte F Ulrich H Palm C | 2007 | J Biomed Mater Res Part A2007，81，3： | 1 |
| 18 | Stress recovery during exposure to natural and urban environments显示文摘 | ULRICH R S SIMONS R F LOSITO B D | 1991 | Journal of Environmental Psychology1991，11，3： | 1 |
| 19 | Development of a pilot scale process for the anti-Alzheimer drug (-)-galanthamine using large-scale phenolic oxidative coupling and crystallisation-induced chiral conversion 显示文摘 | Bernhard K Laszlo C Johannes F Ulrich J | 1999 | Organic Process Research & Development1999，3，6： | 1 |
| 20 | Block copolymer-ceramic hybrid materials from organically modified ceramic precursors 显示文摘 | SIMON P F W ULRICH R SPIESS H W | 2001 | Chemical of Materials2001，13，10： | 1 |
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