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| 1 | Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups显示文摘AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White participants.METHODS:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA levels.Additionally,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the stool.We used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all samples.RESULTS:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic groups.We also found that participant microbial profiles differed by racial/ethnic group.African Americans had significantly more Firmicutes than Whites,with enriched Ruminococcaceae.The Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of butyrate.We also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in stool.CONCLUSION:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions. | Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 2 | Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma 显示文摘 | Umar A Polyak K | 1998 | Pro Natl Acad Sci USA1998，95，12： | 1 |
| 3 | Pediatric pulmonary hypertension:Roles of endothelin-1 and nitric oxide显示文摘 | Black S M K umar S Wiseman D | 2007 | Clin Hemorheol Microcireulation2007，37，： | 1 |
| 4 | Effects of fibrin glue on injuried rabbits urter显示文摘 | K umar U Dckerson Asakanmte K | 2001 | endouro12001，15，2： | 1 |
| 5 | Electroanalytical determination of acetaminophen using nano-TiOz/polymer coated electrode in the presence of dopamine显示文摘 | umar S A K Tang C F Chela S M | 2008 | Talanta2008，76，： | 1 |
| 6 | Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma显示文摘 | Herman JG Umar A Polyak K | 1998 | Proc Nail Acad Sci USA1998，95，： | 1 |
| 7 | The specific role of isofla- vones on estrogen metabolism in premenopausal women显示文摘 | K umar NB Cantor A Allen K | 2002 | Cancer2002，94，4： | 1 |
| 8 | The microbial community composition changes rapidly in the early stages of decomposition of wheat residue显示文摘 | Marschner P Umar S Baumann K | | 0，，： | 1 |
| 9 | Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma显示文摘 | Herman JG Umar A Polyak K | 1998 | Proc Natl Acad Sci USA1998，95，25： | 1 |
| 10 | Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma显示文摘 | Herman JG Umar A Polvak K | 1998 | Genetics1998，95，12： | 1 |
| 11 | Mechanical reinforcement of polymers using carbon nanotubes显示文摘 | JONATHAN N COLEMAN UMAR KHAN YURII K GUN'KO | 2006 | 18(6):689 -7062006，18，6： | 1 |
| 12 | Effect of SOP on yield and quality of potato显示文摘 | Bansal S K and Umar S | 1998 | Fertiliser News1998，43，11： | 1 |
| 13 | An overview of biomass energy utilization in Pakistan 显示文摘 | Umar K Mirza Nasir Ahmad Tariq Majeed | 2008 | Renewcble And Energy Reviews2008，12，7： | 1 |
| 14 | Mechanical, Thermal and Morphological Behavior of Bismaleimide Modified Polyu- rethane-epoxy IPN Matrices显示文摘 | Mahesh K P O Alagar M K umar A | 2003 | Polymers for Advanced Techologies2003，14，： | 1 |
| 15 | Catalytic Ring-opening Polymerization of L-lactide by Titanium Biphenoxy-alkoxide Initiators显示文摘 | Umare P S Tembe G L Rao K V etal | 2007 | Journal of Molecular Catalysis A:Chemical2007，268，： | 1 |
| 16 | Successful treatment of perineal necrotising fasciitis and associated pubic bone os- teomyelitis with the vacuum assisted closure system 显示文摘 | K umar S O'Donnell ME Khan K | 2008 | World J Surg Oncol2008，6，： | 1 |
| 17 | Effect on neem formulations on reproduction and oviposition of rice hoppers Nilapavata lugens,Sogatella furcifera and Nephotettix virescens 显示文摘 | umar K Mahesh Krishnaiah N V Lingaiah T | 2001 | Pesticide Research Journal2001，13，1： | 1 |
| 18 | Catalytic ring-o- pening polymerization of L--lactide by litanium bi- phenoxy-alkoxide initiators显示文摘 | Umare P S Tembe G L Ran K V | 2007 | Journal of Molecular Catalysis A : Chemical2007，268，： | 1 |
| 19 | The Uptake of Caesium and Strontium Radioisotopes onto Clays显示文摘 | Allen Dyer John K K Chow Umar | 2000 | Mater Chem2000，10，： | 1 |
| 20 | Cardiovascular effects of total intravenous anesthesia using ketamine-medetomidine-propofol(KMP-TIVA)in horses undergoing surgery显示文摘 | Umar M A Fukui S Kawase K | 2014 | Journal of Veterinary Medical Science2014，77，3： | 1 |
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