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| 1 | Knockdown of MLO genes reduces susceptibility to powdery mildew in grapevine显示文摘Erysiphe necator is the causal agent of powdery mildew(PM),one of the most destructive diseases of grapevine.PM is controlled by sulfur-based and synthetic fungicides,which every year are dispersed into the environment.This is why PM-resistant varieties should become a priority for sustainable grapevine and wine production.PM resistance can be achieved in other crops by knocking out susceptibility S-genes,such as those residing at genetic loci known as MLO(Mildew Locus O).All MLO S-genes of dicots belong to the phylogenetic clade V,including grapevine genes VvMLO7,11 and 13,which are upregulated during PM infection,and VvMLO6,which is not upregulated.Before adopting a gene-editing approach to knockout candidate S-genes,the evidence that loss of function of MLO genes can reduce PM susceptibility is necessary.This paper reports the knockdown through RNA interference of VvMLO6,7,11 and 13.The knockdown of VvMLO6,11 and 13 did not decrease PM severity,whereas the knockdown of VvMLO7 in combination with VvMLO6 and VvMLO11 reduced PM severity up to 77%.The knockdown of VvMLO7 and VvMLO6 seemed to be important for PM resistance,whereas a role for VvMLO11 does not seem likely.Cell wall appositions(papillae)were present in both resistant and susceptible lines in response to PM attack.Thirteen genes involved in defense were less upregulated in infected mlo plants,highlighting the early mlo-dependent disruption of PM invasion. | Stefano Pessina Luisa Lenzi Michele Perazzolli Manuela Campa Lorenza Dalla Costa Simona Urso Giampiero Valè Francesco Salamini Riccardo Velasco Mickael Malnoy | 2016 | Horticulture Research2016，3，1： | 7 |
| 2 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 3 | Photorefractive keratectomy after cataract surgery in uncommon cases: long-term results显示文摘AIM: To evaluate the efficacy and safety of the excimer laser correction of the residual refractive errors after cataract extraction with intraocular lens(IOL) implantation in uncommon cases.METHODS: Totally 24 patients with high residual refractive error after cataract surgery with IOL implantation were examined. Twenty-two patients had a history of phacoemulsification and IOL implantation, and two had extra-capsular cataract extraction with IOL implantation. Detailed examination of preoperative medical records was done to explain the origin of the post-cataract refractive errors. All patients underwent photorefractire keratectomy(PRK) enhancement. The mean outcome measures were refraction, uncorretted visual acuity(UCVA), best corrected visual acuity(BCVA) and corneal transparency and follow up ranged from 1 to 8 y.RESULTS: The principal causes of residual ametropia was inexact IOL calculation in abnormal eyes with high myopia and congenital lens abnormalities, followed by corneal astigmatism both suture induced and preexisting. After cataract surgery and before the laser enhancement the mean spherical equivalent(SE) was-0.56±3 D ranging from-4.62 to +2.25 D in high myopic patients, instead it was-1±1.73 D ranging from-3.25 to +3.75 D in the astigmatic eyes, with a mean cylinder of-3.75±0 ranging from-3 to +5.50 D. After laser refractive surgery the mean SE was 0.1±0.73, ranging from-0.50 to +1.50 in the myopic group, and it was-0.50±0.57 ranging from-1.25 to +0.50 in astigmatic patients, with a mean cylinder of-0.25±0.75. In myopic patients the mean UCVA and BCVA were 0.038±0.072 logMAR and 0.018±0.04 respectively, both ranging from 0.10 to 0.0. In astigmatic patients, the mean UCVA and BCVA were 0.213±0.132 and 0.00±0.0 respectively, UCVA ranging from 0.50 to 0.22 and BCVA was 0.00. All patients presented normal corneal transparency. No ocular hypertension was detected and no corneal haze was observed. All registered values remained stable also at the end line evaluation.CONCLUSION: The excimer laser treatment of residual refractive errors after cataract surgery with IOL implantation in abnormal eyes resulted in satisfactory and stable visual outcome with good safety and efficacy. | Anna Maria Roszkowska Mario Urso Giuseppe Alberto Signorino Leopoldo Spadea Pasquale Aragona | 2018 | International Journal of Ophthalmology(English edition)2018，11，4： | 4 |
| 4 | A least squares approach to principal component analysis for interval valued data显示文摘 | Pierpaolo D’Urso Paolo Giordani | 2004 | Chemometrics and Intelligent Laboratory Systems2004，，2： | 2 |
| 5 | Presence of CD4^+ SP and DP(gammadelta,alphabeta) T-cells expressing BPDE-DNA adducts in progeny of mouse dams exposed to benzo(alpha)pyrene at mid-gestation显示文摘 | Moolenaar-Wirsiy P J Wirsiy Y G Urso P | 2007 | J Immunotoxicol2007，4，： | 1 |
| 6 | Current-dependent and-independent methods to investigate the microbial ecology of Italian fermented sausages显示文摘 | RANTSIOU K URSO R IACUMIN L | 2005 | Applied and Environmental Microbiology2005，71，： | 1 |
| 7 | Results of a pancreatectomy with a limited venous resection for pancreatic cancer显示文摘 | Giulio Illuminati Fabio Carboni Riccardo Lorusso Antonio D’Urso Gianluca Ceccanei Vassilios Papaspyropoulos Maria Antonietta Pacile Eugenio Santoro | 2008 | Surgery Today2008，，6： | 1 |
| 8 | Transient osteoporosis of the knee显示文摘 | Parker RK Ross G J Urso JA | | 0，，05： | 1 |
| 9 | Selective inhibition of human erythrocyte Na^+/K^+ ATPase by cardiac glycosides and by a mammalian digitalis like factor显示文摘 | Balzan S Urso GD Ghione S | 2000 | Life Sci2000，67，： | 1 |
| 10 | Central neurocytoma:two case reports and review of the literature显示文摘 | Tommasi A D'Urso P Tommasi C | 2006 | Neurosurg Rev2006，29，6： | 1 |
| 11 | Dermatofibrosarcoma protuberans in childhood:two case reports and review of the literature显示文摘 | Gerlini G Mariotti G Urso C | 2008 | Pediatr Hematol Oncol2008，25，6： | 1 |
| 12 | Insulin resistance:receptor and post-receptor abnormalities显示文摘 | Liguori M Urso R Fatigante G | 1998 | Minerva Endocrinol1998，23，2： | 1 |
| 13 | Least squares estimation of a linear regression model with LR fuzzy response显示文摘 | Cope R D'Urso P Giordani P | 2006 | Computational Statististics & Data Analysis2006，51，： | 1 |
| 14 | Spoilage of blood sausages morcilla de Burgos treated with high hy d ro s t a t i c p r e s sure显示文摘 | DIEZ A M URSO R RANTSIOU K | 2008 | International Journal of Food Microbiology2008，，123： | 1 |
| 15 | Analysis of Chatter Vibration Phenomena of Roiling Mills Using Finite Element Methods显示文摘 | Guo R M Urso A C Schunk J H | 1993 | Iron and Steel Eng1993，70，7： | 1 |
| 16 | Ecology of lactic acid bacteria in Italian fermented sausages:Isolation,identification and molecular characterization显示文摘 | URSO R COMI G COCOLIN L | 2006 | Systematic and Applied microbiology2006，29，8： | 1 |
| 17 | Signaling through the insulin receptor显示文摘 | Whitehead JP Clark SF Urso B | 2000 | Curt Opin Cell Biol2000，12，2： | 1 |
| 18 | Spontaneous carotid cav- ernous fistula supplied by the eontralateral meningohypophyseal trunk:case report and literature review 显示文摘 | De Blasi R D'Urso PI Colamaria A | 2010 | J Neurosurg Sci2010，54，： | 1 |
| 19 | Flow diversion for intracranial aneurysms: a review显示文摘 | D'Urso PI Lanzino G Cloft HJ | 2011 | Stroke2011，42，8： | 1 |
| 20 | Treatment for acute asthma in the Emergency Department:practical aspects显示文摘 | Urso DL | 2010 | Eur Rev Med Pharmacol Sci2010，14，3： | 1 |
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