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| 1 | Utility of tricalcium phosphate and osteogenic matrix cell sheet constructs for bone defect reconstruction显示文摘AIM: To determine the effects of transplanting osteogenic matrix cell sheets and beta-tricalcium phosphate(TCP) constructs on bone formation in bone defects.METHODS: Osteogenic matrix cell sheets were prepared from bone marrow stromal cells(BMSCs), and a porous TCP ceramic was used as a scaffold. Three experimental groups were prepared, comprised of TCP scaffolds(1) seeded with BMSCs;(2) wrapped with osteogenic matrix cell sheets; or(3) both. Constructs were implanted into a femoral defect model in rats and bone growth was evaluated by radiography, histology, biochemistry, and mechanical testing after 8 wk. RESULTS: In bone defects, constructs implanted with cell sheets showed callus formation with segmentalor continuous bone formation at 8 wk, in contrast to TCP seeded with BMSCs, which resulted in bone nonunion. Wrapping TCP constructs with osteogenic matrix cell sheets increased their osteogenic potential and resulting bone formation, compared with conventional bone tissue engineering TCP scaffolds seeded with BMSCs. The compressive stiffness(mean ± SD) values were 225.0 ± 95.7, 30.0 ± 11.5, and 26.3 ± 10.6 MPa for BMSC/TCP/Sheet constructs with continuous bone formation, BMSC/TCP/Sheet constructs with segmental bone formation, and BMSC/TCP constructs, respectively. The compressive stiffness of BMSC/TCP/Sheet constructs with continuous bone formation was significantly higher than those with segmental bone formation and BMSC/TCP constructs.CONCLUSION: This technique is an improvement over current methods, such as TCP substitution, and is useful for hard tissue reconstruction and inducing earlier bone union in defects. | Tomoyuki Ueha Manabu Akahane Takamasa Shimizu Yoshinobu Uchihara Yusuke Morita Naoya Nitta Akira Kido Yusuke Inagaki Kenji Kawate Yasuhito Tanaka | 2015 | World Journal of Stem Cells2015，7，5： | 7 |
| 2 | Human T cell leukemia virus type-I-infected patients with Hashimoto's thyroiditis and Graves' disease显示文摘 | Matsuda T Tomita M Uchihara JN | 2005 | Clin Endocrinol Metab2005，90，10： | 1 |
| 3 | Enhanced expression of aquaporin-4 in human brain with infarction显示文摘 | Aoki K Uchihara T Tsuchiya K | 2003 | Acta Neuropathol (Berl)2003，6，2： | 1 |
| 4 | Enhanced expression of aquaporin 4 in human brain with infarction显示文摘 | Aoki K Uchihara T Tsuchiya K | 2003 | Acta Neuropathol(Berl)2003，106，： | 1 |
| 5 | Effect of EDTA on the photacatalytic activities and flatband potentials of cadmium and cadmium selenide 显示文摘 | Matsumura M Tsubomura H | 1990 | J Phys Chem1990，94，1： | 1 |
| 6 | Enhanced expression of aquaporin 4 in human brain with infarction显示文摘 | AOKI K UCHIHARA T TSUCHIYA K | 2003 | Acta Neuropath (Berl)2003，106，2： | 1 |
| 7 | Expression of the Bax inhibitor-1 gene in pulmonary adenocarcinoma 显示文摘 | Tanaka R Ishiyama T Uchihara T | 2006 | Cancer2006，106，3： | 1 |
| 8 | Primary adrenal adult Tcell leukemia lymphoma:a case report and review of the literature显示文摘 | Tomoyose T Nagasaki A Uchihara JN | 2007 | AmJ Hematol2007，82，8： | 1 |
| 9 | Enhanced expression of aquaporin 4 in human brain with infarction显示文摘 | Oki K Uchihara T Tsuchiya K | 2003 | Acta Neuropathol2003，106，2： | 1 |
| 10 | Core promoter/precore mutations are associated with lamivudine-induced HBeAg loss in chronic hepatitis B with genotype C显示文摘 | Asahina Y Izumi N Uchihara M | 2003 | J Hepatol2003，39，6： | 1 |
| 11 | SCA17, a novel autosomal dominant eerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein显示文摘 | Nakamura K Jeong SY Uchihara T | 2001 | Hum Mol Genet2001，10，： | 1 |
| 12 | Intractable hiccup caused by medulla oblongata lesions:A study of an autopsy patient with possi- ble neuromyelitis optica 显示文摘 | Kobayashi Z Tsuchiya K Uchihara T | 2009 | Journal of the Neurological Sciences2009，285，12： | 1 |
| 13 | Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of hu-man T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells 显示文摘 | TOMITA M KAWAKAMI H UCHIHARA J N | 2006 | Int J Cancer2006，118，3： | 1 |
| 14 | CD69 overexpression by human T-cell leukemia virus type I tax transactivation显示文摘 | Ishikawa C Kawakami H Uchihara JN | 2013 | Biochim Bio Phys Acta2013，1833，6： | 1 |
| 15 | Risk factors for distant recurrence of hepatocel- lular carcinoma in the liver after complete coagulation by micro- wave or radiofrequency ablation显示文摘 | Izumi N Asahina Y Noguchi O Uchihara M Kanazawa N Itakura J | 2001 | Cancer2001，91，： | 1 |
| 16 | Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV- 1-infected T-cell lines显示文摘 | Tomita M Kawakami H Uchihara JN | 2006 | Leuk Res2006，30，3： | 1 |
| 17 | Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines显示文摘 | Tomita M Kawakami H Uchihara J | 2006 | Leuk Res2006，30，3： | 1 |
| 18 | Primary adrenal adult T-cell leukemia/lymphoma: a case report and review of the literature显示文摘 | Tomoyose T Nagasaki A Uchihara jN | 2007 | Am J Hematol2007，82，8： | 1 |
| 19 | Neuronatin expression and its clinicopathological significance in pulmonary non-small cell carcino- ma 显示文摘 | Uchihara T Okubo C Tanaka R | 2007 | Thorac Oncol2007，2，9： | 1 |
| 20 | Expression of the Bax inhibitor-1 gene in pulmonary adenocarcinoma显示文摘 | Tanaka R Ishiyama T Uchihara T | 2006 | Cancer2006，106，3： | 1 |
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