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| 1 | 速尿、苯氧比酸、硫唑嘌呤对慢性炎症性肠病患者红细胞TPMT活性的影响显示文摘目的:研究利尿剂速尿、苯氧比酸及其硫唑嘌呤对慢性炎症性肠病患者红细胞硫嘌呤甲基转移酶(TPMT)活性的影响。方法:应用高效液相法(HPLC)测定慢性炎症性肠病患者红细胞TPMT活性,其中中等活性、正常活性、较高活性的患者各6例,依据浓度效应曲线计算每个药物的IC50。结果:速尿对TPMT活性的抑制作用较强,平均IC50为15~19μmol·L-1,在健康志愿者的正常血浆浓度范围内。苯氧比酸和硫唑嘌呤的平均IC50值分别为300~313μmol·L-1、430~532μmol·L-1,均远高于体内所能达到的血浆浓度。3种药物的IC50值在3个不同TPMT活性组间无明显差异(P>0.05)。结论:速尿可抑制红细胞TPMT活性,当速尿和硫嘌呤类药物合用时,应警惕发生不良相互作用。 | 辛华雯 Christine Fischer Matthias Schwab Ulrich Klotz | 2005 | 中国临床药理学与治疗学2005，10，6： | 3 |
| 2 | Postoperative morbidity and long-term survival after pancreaticoduodenectomy with superior mesenterico-portal vein resection显示文摘 | Hartwig Riediger M.D. Frank Makowiec M.D. Eva Fischer Ulrich Adam M.D. Ulrich T. Hopt M.D | 2006 | Journal of Gastrointestinal Surgery2006，，8： | 1 |
| 3 | Intrahepatic IL-8 producing Foxp3 + CD4 + regulatory T cells and fibrogenesis in chronic hepatitis C<!-- Doctopic: VH -->显示文摘 | Bettina Langhans Benjamin Kr?mer Marcell Louis Hans Dieter Nischalke Robert Hüneburg Andrea Staratschek-Jox Margarethe Odenthal Steffen Manekeller Michael Schepke J?rg Kalff Hans-Peter Fischer Joachim L. Schultze Ulrich Spengler | 2013 | Journal of Hepatology2013，，2： | 1 |
| 4 | Postoperative Morbidity and Long-term Survival After Pancreaticoduodenectomy With Superior Mesenterico?Portal Vein Resection显示文摘 | Hartwig Riediger Frank Makowiec Eva Fischer Ulrich Adam Ulrich T. Hopt | 2006 | Journal of Gastrointestinal Surgery2006，，8： | 1 |
| 5 | Interferon/antioxidant combination therapy for chronic hepatitis C—a controlled pilot trial显示文摘 | Markus P Look Alexandra Gerard Govind S Rao Thomas Sudhop Hans-Peter Fischer Tilman Sauerbruch Ulrich Spengler | 1999 | Antiviral Research1999，，2： | 1 |
| 6 | Long-term Outcome After Resection for Chronic Pancreatitis in 224 Patients显示文摘 | Hartwig Riediger Ulrich Adam Eva Fischer Tobias Keck Frank Pfeffer Ulrich T. Hopt Frank Makowiec | 2007 | Journal of Gastrointestinal Surgery2007，，8： | 1 |
| 7 | Reduced expression of Ca^(2+)-regulating proteins in the upper gastrointestinal tract of patients with achalasia显示文摘AIM: To compare expression of Ca2+-regulating proteins in upper gastrointestinal (GI) tract of achalasia patients and healthy volunteers and to elucidate their role in achalasia. METHODS: Sarcoplasmic reticulum Ca2+ ATPase (SERCA) isoforms 2a and 2b, phospholamban (PLB), calsequestrin (CSQ), and calreticulin (CRT) were assessed by quantitative Western blotting in esophagus and heart of rats, rabbits, and humans. Furthermore, expression profi les of these proteins in biopsies of lower esophageal sphincter and esophagus from patients with achalasia and healthy volunteers were analyzed. RESULTS: SERCA 2a protein expression was much higher in human heart (cardiac ventricle) compared to esophagus. However, SERCA 2b was expressed predominantly in the esophagus. The highest CRT expression was noted in the human esophagus, while PLB, although highly expressed in the heart, was below our detection limit in upper GI tissue. Compared to healthy controls, CSQ and CRT expression in lower esophageal sphincter and distal esophageal body were signif icantly reduced in patients with achalasia (P < 0.05). CONCLUSION: PLB in the human esophagus mightbe of lesser importance for regulation of SERCA than in heart. Lower expression of Ca2+ storage proteins (CSQ and CRT) might contribute to increased lower esophageal sphincter pressure in achalasia, possibly by increasing free intracellular Ca2+. | Harald Fischer Judith Fischer Peter Boknik Ulrich Gergs Wilhelm Schmitz Wolfram Domschke Jan W Konturek Joachim Neumann | 2006 | World Journal of Gastroenterology2006，12，37： | 1 |
| 8 | As- sessment of chemical process hazards in early design sta- ges显示文摘 | Shailesh Shah Ulrich Fischer Konrad Hungerbuhler | 2005 | Journal of Loss Prevention in the Process Indus- tries2005，18，： | 1 |
| 9 | Soil conditions and phylogenetic relatedness influence total community trait space during early plant succession显示文摘Aims the total space of traits covered by the members of plant com-munities is an important parameter of ecosystem functioning and complexity.We trace the variability of trait space during early plant succession and ask how trait space co-varies with phylogenetic community structure and soil conditions.Particularly,we are inter-ested in the small-scale variability in trait space and the influence of biotic and abiotic filters.Methods We use data on species richness and soil conditions from the first 7 years of initial succession of an artificial catchment in north-east-ern germany.total functional attribute diversity serves as a proxy to total trait space.Important Findingstotal trait space steadily increased during succession.We observed high small-scale variability in total trait space that was positively correlated with species richness and phylogenetic segregation and negatively correlated with total plant cover.trait space increased with soil carbonate content,while pH and the fraction of sandy material behaved indifferently.our results indicate that during early succession,habitat filtering processes gain importance leading to a lesser increase in trait space than expected from the increase in species richness alone. | Werner Ulrich Marcin Piwczyński Markus K.Zaplata Susanne Winter Wolfgang Schaaf Anton Fischer | 2014 | Journal of Plant Ecology2014，7，4： | 1 |
| 10 | Wastewater reuse:a new approach to screen for designs with minimal total costs显示文摘 | Gerald Jodicke Ulrich Fischer | 2001 | Comput Chem Eng2001，25，： | 1 |
| 11 | Long-term Outcome After Resection for Chronic Pancreatitis in 224 Patients显示文摘 | Hartwig Riediger Ulrich Adam Eva Fischer Tobias Keck Frank Pfeffer Ulrich T. Hopt Frank Makowiec | 2007 | Journal of Gastrointestinal Surgery2007，，8： | 1 |
| 12 | A Discrete Ordinates Nodal Method for One-Dimensional Neutron Transport Numerical Calculation in Cnrvilin ear Geometries显示文摘 | Wu Y Xie Z Ulrich Fischer | | 0，，： | 1 |
| 13 | Interferon/antioxidant combination therapy for chronic hepatitis C—a controlled pilot trial显示文摘 | Markus P Look Alexandra Gerard Govind S Rao Thomas Sudhop Hans-Peter Fischer Tilman Sauerbruch Ulrich Spengler | 1999 | Antiviral Research1999，，2： | 1 |
| 14 | Assigning functions to nucleolar structures显示文摘 | Dagmar Fischer Dieter Weisenberger Ulrich Scheer | 1991 | Chromosoma1991，，3： | 1 |
| 15 | Intrahepatic IL-8 producing Foxp3 + CD4 + regulatory T cells and fibrogenesis in chronic hepatitis C显示文摘 | Bettina Langhans Benjamin Kr?mer Marcell Louis Hans Dieter Nischalke Robert Hüneburg Andrea Staratschek-Jox Margarethe Odenthal Steffen Manekeller Michael Schepke J?rg Kalff Hans-Peter Fischer Joachim L. Schultze Ulrich Spengler | 2013 | Journal of Hepatology2013，，2： | 1 |
| 16 | A Discrete Ordinates Nodal Method for One-Dimensional Neutron Transport Numerical Calculation in Curvilinear Geometries 显示文摘 | Yican Wu Zhongsheng Xie Ulrich Fischer | 1999 | Nuclear Science and Engineering1999，133，： | 1 |
| 17 | Wastewater reuse:a new approach to screen for designs with minimal totalcosts 显示文摘 | Gerald J S dicke Ulrich Fischer | 2001 | Comput Chem Eng2001，25，： | 1 |
| 18 | Diversity and dynamic of sen- sory related traits in different apple cultivars显示文摘 | ULRICH D HOBERG E FISCHER C | 2009 | Journal of Applied Botany and Food Quality2009，83，： | 1 |
| 19 | Split liver transplantation and risk to the adult recipient: analysis using matched pairs显示文摘 | Dieter C Broering Stefan Topp Ulrich Schaefer Lutz Fischer Matthias Gundlach Martina Sterneck Volker Schoder Werner Pothmann Xavier Rogiers | 2002 | Journal of the American College of Surgeons2002，，5： | 1 |
| 20 | Long-term Outcome After Resection for Chronic Pancreatitis in 224 Patients显示文摘 | Hartwig Riediger Ulrich Adam Eva Fischer Tobias Keck Frank Pfeffer Ulrich T. Hopt Frank Makowiec | 2007 | Journal of Gastrointestinal Surgery2007，，8： | 1 |
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