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| 1 | HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity显示文摘 | Clement V Sanchez P de Tribolet N Radovanovic I Ruiz i Altaba A | 2007 | 中国神经肿瘤杂志2007，5，2： | 96 |
| 2 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 3 | 基于EEMD-Hilbert包络谱和DBN的变负载下滚动轴承状态识别方法显示文摘负载在滚动轴承的运行过程中通常是变化的,针对变负载下滚动轴承不同故障位置及不同性能退化程度多状态识别困难的问题,提出一种基于集合经验模态分解–希尔伯特(ensemble empirical mode decomposition-Hilbert,EEMD-Hilbert)包络谱和深度信念网络(deep belief network,DBN)的滚动轴承状态识别方法。该方法首先对滚动轴承各状态振动信号进行EEMD,然后选取敏感本征模态函数(intrinsic mode function,IMF),并对其进行Hilbert变换求取包络谱。最后将各状态振动信号的IMF包络谱按顺序构建新的高维数据,输入到经遗传算法优化各隐藏层节点结构的DBN中,实现变负载下滚动轴承的多状态识别。实验结果表明:在运用DBN进行滚动轴承10种状态识别过程中,训练数据采用某种负载,测试数据选用其他负载的情况下,EEMD-Hilbert包络谱比时域或频域幅值谱能更好地体现出滚动轴承不同负载下的多状态特征;且DBN相对浅层学习的支持向量机和BP神经网络算法,具有更高的识别率,各数据集识别率均达到92.5%以上。 | 王玉静 那晓栋 康守强 谢金宝 V I MIKULOVICH | 2017 | 中国电机工程学报2017，37，23： | 34 |
| 4 | 基于集合经验模态分解敏感固有模态函数选择算法的滚动轴承状态识别方法显示文摘为了更有效地提取滚动轴承各状态振动信号的特征,该文提出了一种基于集合经验模态分解(EEMD)的敏感固有模态函数(IMF)选择算法。该算法对振动信号经EEMD分解后得到的固有模态函数采用峭度值、相关系数相结合的方法自动提取其敏感分量,以此获得振动信号的初始特征。再运用奇异值分解和自回归(AR)模型方法得到滚动轴承各状态振动信号的特征向量,并将其输入到改进的超球多类支持向量机中进行智能识别,从而实现滚动轴承的正常状态,不同故障类型及不同性能退化程度的各状态识别。实验结果表明,相比基于经验模态分解结合自回归模型或奇异值分解的特征提取方法,该方法可更有效地提取滚动轴承故障特征信息,且识别精度更高。 | 王玉静 康守强 张云 刘学 姜义成 Mikulovich V I | 2014 | 电子与信息学报2014，36，3： | 30 |
| 5 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 6 | 结合CNN和LSTM的滚动轴承剩余使用寿命预测方法显示文摘针对滚动轴承存在性能退化渐变故障和突发故障两种模式下的剩余使用寿命(remaining useful life,简称RUL)预测困难的问题,提出一种结合卷积神经网络(convolution neural networks,简称CNN)和长短时记忆(long short term memory,简称LSTM)神经网络的滚动轴承RUL预测方法。首先,对滚动轴承原始振动信号作快速傅里叶变换(fast Fourier transform,简称FFT);其次,将预处理所得到的频域幅值信号进行归一化处理后,将其作为CNN的输入,并利用CNN自适应提取局部内在有用信息,学习并挖掘深层特征,避免传统算法需要专家大量经验的弊端;然后,再将深层特征输入到LSTM网络中,构建趋势性量化健康指标,同时确定失效阈值;最后,运用移动平均法进行平滑处理,消除局部振荡,再利用多项式曲线拟合,预测未来失效时刻,实现滚动轴承RUL预测。实验结果表明,所提方法构建的趋势性量化健康指标在两种故障模式下都具有良好的单调趋势性,预测结果能够较好地接近真实寿命值。 | 王玉静 李少鹏 康守强 谢金宝 MIKULOVICH V I | 2021 | 振动.测试与诊断2021，41，3： | 26 |
| 7 | 基于MCEA-KPCA和组合SVR的滚动轴承剩余使用寿命预测显示文摘为了准确预测滚动轴承的剩余使用寿命(RUL),提出一种多评价标准有效性分析(MCEA)、核主成分分析(KPCA)和组合支持向量回归(SVR)相结合的滚动轴承RUL预测方法。该方法对提取的特征计算每个评价标准的有效性得分,自适应地确定每个评价标准的权重,筛选出有效性总得分高于其整体平均值的特征,进一步利用KPCA去除已筛选特征之间的信息冗余,建立约简后的特征矩阵。将多个轴承约简后的特征分别作为SVR的输入,当前使用寿命与全寿命的比值p即RUL作为输出,建立多个SVR模型,并采用自适应的方法确定各模型的权重,最终构建组合SVR预测模型。最后,对与训练不同的轴承进行测试,将约简后特征输入到组合SVR预测模型中,预测轴承的p值,实验结果表明,所提方法可准确地对滚动轴承进行RUL预测。 | 康守强 叶立强 王玉静 谢金宝 Mikulovich V I | 2017 | 电子测量与仪器学报2017，31，9： | 21 |
| 8 | Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia显示文摘Cervical cancer is a worldwide disease that constitutes a significant public health problem, especially in developing countries, not only due to its high incidence but also because the most affected population comprises women who belong to marginalized socio-economic classes. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients. Human Papillomavirus(HPV) has several mechanisms for avoiding the immune system: it down-regulates the expression of interferon and upregulates interleukin(IL)-10and transforming growth factor(TGF)-β1 to produce a local immunosuppressive environment, which, along with altered tumor surface antigens, forms an immunosuppressive network that inhibits the antitumor immune response. In this review we analyzed the available data on several deregulated cellular immune functions in patients with NIC Ⅰ, NIC Ⅱ and NIC Ⅲ and cervical cancer. The effects of immunosuppressive cytokines on innate immune response, T-cell activation and cellular factors that promote tumor cell proliferation in cervical cancer patients are summarized. We discuss the functional consequences of HPV E2, E6, and E7 protein interactions with IL-10 and TGF-β1 promoters in the induction of these cytokines and postulate its effect on the cellular immune response in squamous intraepithelial cervical lesions and cervical cancer patients. This review provides a comprehensive picture of the immunological functions of IL-10 and TGF-β1 in response to HPV in humans. | Kirvis Torres-Poveda Margarita Bahena-Román Claudia Madrid-González Ana I Burguete-García Víctor Hugo Bermúdez-Morales Oscar Peralta-Zaragoza Vicente Madrid-Marina | 2014 | World Journal of Clinical Oncology2014，5，4： | 21 |
| 9 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 10 | Predictive value of multi-detector computed tomography for accurate diagnosis of serous cystadenoma:Radiologic-pathologic correlation显示文摘AIM:To identify multi-detector computed tomography(MDCT) features most predictive of serous cystadenomas(SCAs),correlating with histopathology,and to study the impact of cyst size and MDCT technique on reader performance.METHODS:The MDCT scans of 164 patients with surgically verified pancreatic cystic lesions were reviewed by two readers to study the predictive value of various morphological features for establishing a diagnosis of SCAs.Accuracy in lesion characterization and reader conf idence were correlated with lesion size(≤3cm or≥3cm) and scanning protocols(dedicated vs routine).RESULTS:28/164 cysts(mean size,39 mm;range,8-92mm) were diagnosed as SCA on pathology.The MDCT features predictive of diagnosis of SCA were microcystic appearance(22/28,78.6%),surface lobulations(25/28,89.3%) and central scar(9/28,32.4%).Stepwise logistic regression analysis showed that only microcystic appearance was signifi cant for CT diagnosis of SCA(P=0.0001).The sensitivity,specificity and PPV of central scar and of combined microcystic appearance and lobulations were 32.4%/100%/100% and 68%/100%/100%,respectively.The reader confidence was higher for lesions>3cm(P=0.02) and for MDCT scans performed using thin collimation(1.25-2.5mm) compared to routine 5 mm collimation exams(P>0.05).CONCLUSION:Central scar on MDCT is diagnostic of SCA but is seen in only one third of SCAs.Microcystic morphology is the most significant CT feature in diagnosis of SCA.A combination of microcystic appearance and surface lobulations offers accuracy comparable to central scar with higher sensitivity. | Anjuli A Shah Nisha I Sainani Avinash Kambadakone Ramesh Zarine K Shah Vikram Deshpande Peter F Hahn Dushyant V Sahani | 2009 | World Journal of Gastroenterology2009，15，22： | 11 |
| 11 | 基于数学形态学和IFOA-SVR的滚动轴承可靠度预测方法显示文摘为了保证滚动轴承运行状态可靠度的预测精度同时增加预测步长,提出一种数学形态学分形维数结合改进果蝇优化算法-支持向量回归(Improved fruit fly optimization algorithm-support vector regression,IFOA-SVR)的滚动轴承可靠度预测方法。提取振动信号的包络信号,计算该包络信号的数学形态学分形维数,将其作为滚动轴承性能退化状态特征。利用IFOA对SVR中的参数C、g以及ε同时进行寻优,建立IFOA-SVR预测模型。利用极大似然估计结合IFOA建立威布尔比例故障率模型(Weibull proportional hazard model,WPHM),进而得到可靠度模型。将退化状态特征作为IFOA-SVR预测模型的输入,采用长期迭代预测法获取特征预测结果,并将该结果嵌入到可靠度模型中,从而预测出轴承运行状态的可靠度。试验结果表明,利用所提方法对滚动轴承可靠度进行预测,能在保证预测精度的前提下增加预测步长。 | 康守强 叶立强 王玉静 谢金宝 MIKULOVICH V I | 2017 | 机械工程学报2017，53，8： | 11 |
| 12 | 嗜水气单胞菌ZN1攻击鳗鲡后的组织病理观察显示文摘采用1/2半致死剂量的嗜水气单胞菌ZN1对鳗鲡进行腹腔注射,在第0 d、1 d、3 d、7 d、14 d、21 d采集鳗鲡肝、脾、肾、肠,观察鳗鲡经嗜水气单胞菌活菌攻击后各脏器的组织病理变化及脏器的损伤修复情况。结果显示,嗜水气单胞菌活菌ZN1攻击后鳗鲡肝、肾、脾、肠等组织细胞均出现程度不同的病变,且持续时间长达14 d以上,同时血液中的血栓细胞急剧减少,甚至全部消失。上述结果表明嗜水气单胞菌攻击后可引发鳗鲡各脏器发生明显的病理变化,并提示在病原菌攻击引起鳗鲡血栓细胞的减少并恢复缓慢可能是嗜水气单胞菌导致宿主产生败血症状的重要病理机制。 | 宋铁英 龚晖 Khomyakova T I 杨金先 李艳虹 Makarova O V 林天龙 | 2008 | 福建农业学报2008，23，1： | 10 |
| 13 | 甲烷浓度对CVD金刚石薄膜晶体学生长过程的影响显示文摘采用X射线衍射技术、电子背散射衍射技术和扫描电镜分别观察了不同甲烷浓度条件下沉积的CVD自支撑金刚石薄膜的宏观织构、微区晶界分布和表面形貌.研究了金刚石晶体{100}面和{111}面生长的晶体学过程.研究表明,{100}面通过吸附活性基团CH2 2-,而{111}面通过交替吸附活性基团CH3 -和CH3-后脱氢堆积碳原子.低甲烷浓度时,{111}面表面能低于{100}面,使{111}面生长略快于{100}面.甲烷浓度升高,动力学作用增强使{100}面生长明显快于{111}面,使金刚石薄膜产生{100}纤维织构;同时显露的{100}面平行于薄膜表面,竞争生长使位于晶体侧面的{111}面由于相互覆盖而减小,形成了不同于单晶体自由生长的薄膜表面形貌组织. | 朱宏喜 毛卫民 冯惠平 吕反修 Vlasov I I Ralchenko V G Khomich A V | 2007 | 无机材料学报2007，22，3： | 9 |
| 14 | 基于深度在线迁移的变负载下滚动轴承故障诊断方法显示文摘针对变负载条件下滚动轴承源域与目标域中相同状态的数据特征分布差异性较大,目标域数据按照序列方式在线获取时,数据更新需重新训练模型的问题,提出一种深度在线迁移的CNN-ISVM (convolutional neural networks-incremental support vector machine)变负载下滚动轴承故障诊断方法.该方法运用短时傅里叶变换得到不同负载下滚动轴承振动信号的频谱图并构建数据集;使用源域数据建立CNN-ISVM预训练模型并保存模型参数;利用迁移学习将源域共享模型参数迁移至目标域CNN-ISVM模型训练过程中,快速建立分类模型;分类模型中的ISVM分类器在保留已学到知识的基础上,在线处理目标域新增数据,无需重新训练.经实验验证,所提出方法可实现数据按照序列方式采集的变负载下滚动轴承多状态在线分类,并具有较好的稳定性及较高的准确率. | 康守强 刘旺辉 王玉静 王庆岩 Mikulovich V I | 2022 | 控制与决策2022，37，6： | 9 |
| 15 | Liver blood supply after a modified Appleby procedure in classical and aberrant arterial anatomy显示文摘Reported here are two cases of a modified Appleby operation for borderline resectable ductal adenocarcinoma of the pancreatic body, in one of which a R0 distal resection was attended to by excision, not only of the celiac axis, but also of the common and left hepatic arteries in the presence of arterial anatomic variation Michels, type Ⅷb. The possibility and avenues of the maintenance of the blood supply to the left hepatic lobe after surgical aggression of this kind are demonstrated employing computed tomography (CT) and 3-D CT angiography. Furthermore, both cases highlight all important worrisome aspects of pancreatic cancer resectability prediction. | Vyacheslav I Egorov Roman V Petrov Michail V Lozhkin Olga A Maynovskaya Natalia S Starostina Natalia R Chernaya Ekaterina M Filippova | 2013 | World Journal of Gastrointestinal Surgery2013，5，3： | 7 |
| 16 | Peripheral blood lymphocytes DNA in patients with chronic liver diseases显示文摘BACKGROUND Viral replication in blood cells with nucleuses may lead to the damage of lymphocytes genetic apparatus and the beginning of immunopathological reactions.AIM Of this investigation is to reveal the damage to peripheral blood lymphocytes (PBL)DNA in the patients with chronic liver diseases.MATERIALS AND METHODS Sixteen-ninepatients with chronic liver diseases (37 patients with chronic viral hepatitis, 2 patients with liver cirrhosis of mixed etiology (alcohol + virus G),30 women with primary biliary cirrhosis-PBC)were examined. The condition of DNA structure of PBL-was measured by the fluorescenceanalysis of DNA unwinding (FADU) technique with modification. Changes of fluorescence (in %) reflected the DNA distractions degree (thepresence of DNA single-stranded breaks and alkalinelabile sights).RESULTS AND CONCLUSION . The quantity of DNA single-stranded breaks and alkalinelabile sightsin DNA in all patients with chronic viral hepatitis .didnt differ from the control group,excluding the patients with chronic hepatitis (CH) C + G. Patients with HGV and TTV monoinfection had demonstrated the increase of the DNA single-stranded breaks PBL quantity.This fact may be connected with hypothesisabout the viruses replication in white blood cells discussed in the literature. Tendency to increase quantity of DNA PBL damages in the patients with primary biliary cirrhosis (PBC) accordingly to the alkaline phosphatase activity increase was revealed. Significant decrease of the DNA single-stranded breaks and alkalinelabile sights in the PBC patients that were treated with prednison was demonstrated. Probably, the tendency to increase the quantity of DNA singlestranded breaks and alkalinelabile sights in lymphocytes of the PBC patients was depended on the surplus of the blood bile acid content. | Vasiliy I Reshetnyak Tatyana I Sharafanova Ludmila U Ilchenko Elena V Golovanova Gennadiy G Poroshenko | 2001 | World Journal of Gastroenterology2001，7，2： | 6 |
| 17 | Incidence and risk factors for the development of anemia following gastric bypass surgery显示文摘AIM:To evaluate the incidence and risk factors for the development of anemia after RouxenY gastric bypass (RYGB).METHODS: A retrospective analysis of patients undergoing RYGB from January 2003 to November 2007 was performed. All patients had a preoperative body mass index > 40 kg/m2. A total of 206 patients were evaluated. All patients were given daily supplements of ferrous sulfate tablets for 2 wk following their operation. Hematological and metabolic indices were routinely evaluated following surgery. Patients were followed for a minimum of 86 wk.RESULTS: There were 41 males and 165 females with an average age of 40.8 years. 21 patients (10.2%) developed postoperative anemia and 185 patients (89.8%) did not. Anemia was due to iron deficiency in all cases. The groups had similar demographics, surgical procedure and comorbidities. Menstruation (P = 0.02) and peptic ulcer disease (P = 0.01) were risk factors for the development of postoperative anemia.CONCLUSION: Iron deficiency anemia is frequent. RYGB surgery compounds occult blood loss. Increased ferrous sulfate supplementation may prevent iron depletion in populations at increased risk. | Dimitrios V Avgerinos Omar H Llaguna Matthew Seigerman Amanda J Lefkowitz I Michael Leitman | 2010 | World Journal of Gastroenterology2010，16，15： | 6 |
| 18 | 液态二氧化碳对俄罗斯某油藏稠油的膨胀与萃取作用实验显示文摘利用俄罗斯某油藏稠油样品,通过实验分析稠油与液态CO_2混合后两者之间的质量传递作用以及混合物中重相(稠油和CO_2的混合物)和轻相(纯CO_2)的特性变化。研究表明,当混合物中CO_2浓度为10%时,稠油基本上不发生膨胀;当混合物中CO_2浓度高于26%时,由于稠油轻质组分的萃取量超过了CO_2在稠油中的饱和量导致重相体积减少,重相黏度呈指数增长,混合物中CO_2的浓度为26%时,有效降低重相黏度的作用最强;重相和轻相密度、体积系数、气体溶解度和闪蒸重相黏度均随着混合物中CO_2浓度的增加而变大;混合物中最佳的CO_2浓度是26%,此时稠油膨胀最大、重相的黏度值最小;混合物中CO_2的浓度为10%~26%时,轻相的体积最小,驱油效果最好。 | LOBANOV A A SHHEKOLDIN K A STRUCHKOV I A ZVONKOV M A HLAN M V PUSTOVA E J KOVALENKO V A ZOLOTUKHIN A B | 2018 | 石油勘探与开发2018，45，5： | 6 |
| 19 | 血管紧张素Ⅱ2型受体的基因多态性(+1675G/A)对已接受治疗高血压患者的左心室肥大和左心室构型的作用显示文摘已有报道显示血管紧张素Ⅱ2型受体的基因多态性(AGTR2+1675G/A)与左心室肥大(left ventric-ular hypertrophy,LVH)相关。研究者检验这种基因多态性是否影响已按高血压治疗指南治疗的原发性高血压和心血管疾病患者的LVH和左心室构型参数。 | 张玲玉 叶鹏 Huber M V ller H Jakob S Reibis R Do V Bol-brinker J Zergibel I Schmieder RE Treszl A Wegscheider K Kreutz R | 2010 | 中华高血压杂志2010，18，12： | 6 |
| 20 | 巨峰和无核早红葡萄在越南谅山试种观察显示文摘[目的]观察巨峰、无核早红葡萄在越南谅山省的引种表现,为其在越南推广种植提供参考依据.[方法]2009年春从中国南宁引入巨峰、无核早红两个鲜食葡萄品种在越南谅山省试种,调查其枝蔓生长量、物候期、果实性状、产量等相关指标.[结果]至第1年抚育冬季,巨峰葡萄枝蔓总长234.5 cm,上架茎粗0.84 cm;无核早红葡萄枝蔓总长294.1 cm,上架茎粗0.86 cm.在物候期方面,巨峰葡萄从萌芽至果实成熟需141~151 d,表现中熟;无核早红从萌芽至果实成熟需142~151 d,未表现其应有的早熟特性.在果实性状方面,巨峰葡萄2010~2012年3年平均单果重8.9 g,种子数1.04粒,可溶性固形物(TSS)含量17.5%;无核早红葡萄2010~2012年3年平均单果重6.8 g,TSS含量13.9%.在产量方面,巨峰葡萄2010~2012年产量分别为13.69、17.50和16.24 t/ha;无核早红葡萄2010~2012年产量分别为10.81、16.02和20.92t/ha.[结论]巨峰葡萄在越南谅山省种植表现丰产稳产优质,具有较好的适栽性,可大面积推广种植;无核早红葡萄表现丰产稳产,但表现低糖低酸,极易裂果,着色困难,不宜在越南大面积发展. | 黄江流 PHAM Thi Thang 罗瑞鸿 NGUYN Thi Hà 吕荣华 LUONG Dǎng Ning CHU Vǎn DUòng NGUYN Manh Tòng 彭宏祥 Ly Ming Nguyet LU'O'NG i Thuy CHU Xun Tien VI Vǎn Dúc NGUYN Duy Dng Ly Dúc Khiêm 熊俏 | 2014 | 南方农业学报2014，45，7： | 5 |
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