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| 1 | ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10(ABCC1O) are not primary resistance factors for cabazitaxel显示文摘Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells.Cabazitaxel is a novel taxane that differs from paclitaxel by its lower affinity for ATP-binding cassette(ABC) transporters.Methods:We determined the effects of cabazitaxel,a novel tubulin-binding taxane,and paclitaxel on paclitaxelresistant,ABCB1-overexpressing KB-C2 and LLC-MDR1-WT cells and paclitaxel-resistant,ABCC10-overexpressing HEK293/ABCC10 cells by calculating the degree of drug resistance and measuring ATPase activity of the ABCB1 transporter.Results:Decreased resistance to cabazitaxel compared with paclitaxel was observed in KB-C2,LLC-MDR1-WT,and HEK293/ABCC10 cells.Moreover,cabazitaxel had low efficacy,whereas paclitaxel had high efficacy in stimulating the ATPase activity of ABCB1,indicating a direct interaction of both drugs with the transporter.Conclusion:ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel,suggesting that cabazitaxel may have a low affinity for these efflux transporters. | Rishil J Kathawala Yi-Jun Wang Suneet Shukla Yun-Kai Zhang Saeed Alqahtani Amal Kaddoumi Suresh V Ambudkar Charles R Ashby Jr Zhe-Sheng Chen | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 2 | 印度农业推广改革现状:战略重点和政策选择显示文摘独立以来,虽然印度农业推广经历了翻天覆地的变化,但是小农农民和其他弱势群体仍未参与到公共推广体系之中。许多组织性能问题妨碍了公共推广体系的效率和效果。这些问题包括人员的匮乏,较低的合作伙伴关系以及继续自上而下的线性推广方式。本文回顾了印度农业推广改革的现状,并基于比哈尔、喜马偕尔邦、马哈拉施特拉邦和泰米尔纳德邦等4个邦的实地调研,分析并进一步细化了当前的改革进程,在此基础上,提出了促进农业公共推广体系有序发展和运行的优先政策和战略选择。 | Suresh C Babu P K Joshi Claire J.Glendenning Kwadwo Asenso-Okyere Rasheed Sulaiman V 蔡彦虹(翻译) | 2017 | 世界农业2017，，7： | 2 |
| 3 | Anatase to rurile transformation in sol-gel titania by modification of precursor 显示文摘 | Suresh C Biju V Mukundan P | 1998 | Polyhedron1998，17，18： | 1 |
| 4 | A novel three-dimensional model to quantify metastatic melanoma invasion 显示文摘 | Ghajar CM Suresh V Peyton SR | 2007 | Mol Cancer Ther2007，6，2： | 1 |
| 5 | The eonneetion between C-reactive protein and athemselerosis显示文摘 | SINGH S K SURESH M V VOLETI B | 2008 | Ann Med2008，40，2： | 1 |
| 6 | Rough-DBSCAN: A fast hybrid density based clustering method for large data sets 显示文摘 | Viswanath P Suresh Babu V | 2009 | Pattern Recognition Letters2009，30，16： | 1 |
| 7 | Glutathione S-transferase M 1 and T1 status and the risk of laryngeal cancer:a meta-analysis显示文摘 | Kumar V Murthy AK Suresh KP | 2011 | Asian Pac J Cancer Prey2011，12，9： | 1 |
| 8 | Effect of stocking density on water quality and production of red tilapia in a recirculated water system 显示文摘 | Suresh A V Lin C K | 1992 | Aquae Engineering1992，，11： | 1 |
| 9 | A Composite Heat Transfer Correlation for Saturated Flow Boiling in Small Channels 显示文摘 | Stefan S B Eckhard A G Suresh V G | 2009 | International Journal of Heat and Mass Transfer2009，52，： | 1 |
| 10 | A dynamic lot sizing problem with multiple customers: customer-specific shipping and backlogging costs 显示文摘 | Suresh C Hsu V N Sethi S Deshpande V | 2007 | IIE Transactions2007，39，： | 1 |
| 11 | En- hancing the hydrogen storage capacity of Pd-functionalized multi-walled carbon nanotubes显示文摘 | Priyanka Singh Mukta V Kulkarmi Suresh P Gokhale | 2012 | Appl Surf Sci2012，258，： | 1 |
| 12 | Role ofsediment characteristics on natural radiation level of the V aigairiver sediment, Tamilnadu, India显示文摘 | Ramasamy V Paramasivam K Suresh G | 2014 | Journal of EnvironmentalRadioactivity2014，127，： | 1 |
| 13 | Recent advances in drying and dehydration of fruits and vegetables: a review显示文摘 | Sagar V R Suresh Kumar P | 2010 | Food Sci Technol (January February)2010，47，1： | 1 |
| 14 | Recent advances in drying and dehydration of fruits and vegetables : a review 显示文摘 | Sagar V R Suresh Kumar P | 2010 | Journal of Food Science and Technology2010，47，： | 1 |
| 15 | Role of light andheavy minerals on natural radioactivity level of high background radi-ation area, Kerala, India显示文摘 | Ramasamy V Sundarrajan M Suresh G | 2014 | Appl Radiat Isot2014，85，： | 1 |
| 16 | Recent developments in modeling of heat transfer during TIG welding-a review 显示文摘 | Varghese V J Suresh M Kumar D S | 2013 | The International Journal of Advanced Manufacturing Technology2013，，58： | 1 |
| 17 | Mechanical behavior of nanocrystalline metals and alloys 显示文摘 | KUMAR K S SWYGENHOVEN H V SURESH S | 2003 | Acta Mater2003，51，19： | 1 |
| 18 | Modeling of disorder and X-ray diffraction in coal-based graphitic carbons显示文摘 | SURESH BAHU V SEEHRA M S | 1996 | Carbon1996，34，10： | 1 |
| 19 | pH dependent eoprecipitated oxalate precursors -- a thermal study of barium titanate 显示文摘 | PRASADARAO A V SURESH M KOMARNENI S | 1999 | Mater Lett1999，39，： | 1 |
| 20 | Tilapia culture in saline waters : a review 显示文摘 | Suresh A V Lin C K | 1992 | Aquaculture1992，106，34： | 1 |
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