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| 1 | Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases显示文摘AIM: To evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases. METHODS: Immunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma. RESULTS: Immunostaining was seen in most cases, and COX-2 expression was higher in lymph node me-tastases than in corresponding primary gastric tumors of intestinal, diffuse and mixed carcinomas, with a statistically signif icant difference in the diffuse histotype (P = 0.0108). CONCLUSION: COX-2 immunoexpression occurs frequently in primary gastric carcinomas, but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype. | Paulo RC Almeida Francisco VA Ferreira Cássio C Santos Francisco D Rocha-Filho Raul RP Feitosa Esther AA Falco Belise K Cavada Roberto CP Lima-Júnior Ronaldo A Ribeiro | 2012 | World Journal of Gastroenterology2012，18，8： | 14 |
| 2 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 3 | Antioxidant potential,tannin and polyphenol contents of seed and pericarp of three Coffea species显示文摘Objective:To investigate the antioxidant activity,total phenolic and total tannin content of the pericarp and the seed of Coffea benghalensis(C.benghalensis) and Coffea liberica compared to Coffea arabica(C.arabica).Methods:The antioxidant potential,total tannin and polyphenol contents of the immature and mature seed and pericarp of C.benghalensis and Coffea liberica were quantified and compared to C.arabica.Enhanced chemiluminescence(ECL).2,2-diphenyl-1-picrylhydruzyl(DPPH).oxygen radical absorbance capacity,Folin-Ciocaltcau method and total tannin content assays were used.Results:Trolox equivalent(TE/g plant material) values obtained by ECL and DPPH methods showed loose correlation(r^2=0.587)while those measured by oxygen radical absorbance capacity assay were higher without correlation in each plant.A closer correlation was detected between the ECL method and the percentage antioxidant activity of the DPPH technique(r^2=0.610 7) in each species,however the immature pericarp of C.benghalensis showed much higher DPPH scavenging potential than was seen in the ECL assay.The immature pericarp of C.benghalensis expressed the highest tannin and polyphenol content,and a high polyphenol level was also detected in the immature seed of C.arabica.The immature pericarp of Bengal and Liberian coffees showed the largest amount of phenolic contents.Conclusions:The obtained data highlight the potential role of C.benghalensis as a new source of natural antioxidants and polyphenols compared to C.arabica. | va Brigitta Patay Nikolett Sali Tams Kszegi Rita Csepregi Viktória Lilla Blaz Tibor Sebastian Németh Tibor Németh Nóra Papp | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 3 |
| 4 | Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues显示文摘The extracellular matrix(ECM) performs essential functions in the differentiation, maintenance and remodeling of tissues during development and regeneration, and it undergoes dynamic changes during remodeling concomitant to alterations in the cell-ECM interactions. Here we discuss recent data addressing the critical role of the widely expressed ECM protein, matrilin-2(Matn2) in the timely onset of differentiation and regeneration processes in myogenic, neural and other tissues and in tumorigenesis. As a multiadhesion adaptor protein, it interacts with other ECM proteins and integrins. Matn2 promotes neurite outgrowth, Schwann cell migration, neuromuscular junction formation, skeletal muscle and liver regeneration and skin wound healing. Matn2 deposition by myoblasts is crucial for the timely induction of the global switch toward terminal myogenic differentiation during muscle regeneration by affecting transforming growth factor beta/bone morphogenetic protein 7/Smad and other signal transduction pathways. Depending on the type of tissue and the pathomechanism, Matn2 can also promote or suppress tumor growth. | éva Korpos Ferenc Deák Ibolya Kiss | 2015 | Neural Regeneration Research2015，10，6： | 2 |
| 5 | 2013年美国心脏病学会/美国心脏协会胆固醇管理指南在美国心脏病学实践中的应用显示文摘2013年美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)胆固醇管理指南建议在符合治疗标准的患者中采用中等强度至高强度他汀类药物治疗。该研究的目的在于审查2013年ACC/AHA指南在美国心脏病学实践中的应用情况。 | 刘莉 叶鹏 Pokharel Y Tang F Jones PG Nambi V Bittner VA Hira RS Nasir K Chan PS Maddox TM Oetgen WJ Heidenreich PA Borden WB Spertus JA Petersen LA Ballantyne CM Virani SS | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 6 | PP2A regulatory subunit PP2A-B'counteracts S6K phosphorylation显示文摘 | Hahn K Miranda M Francis VA | 2010 | Cell Metabol2010，11，5： | 1 |
| 7 | Renal sodium-glucose transport : role in diabetes mellitus and potentialclinical implications 显示文摘 | Bakris GL* Fonseca VA Sharma K | 2009 | Kidney Int2009，75，12： | 1 |
| 8 | Autophagy proteins reg- ulate innate immune responses by inhibiting the release of mitoehon- drial DNA mediated by the NALP3 inflammasome显示文摘 | Nakahira K Haspel JA Rathinam VA | 2011 | Nat Immunol2011，12，3： | 1 |
| 9 | Progesterone is essential for maintenance and growth of uterine leiomyoma显示文摘 | Ishikawa H Ishi K Serna VA | 2010 | Endocrinol2010，151，6： | 1 |
| 10 | Brain abnormalities in neuromyelitis optica 显示文摘 | Pittock SJ Lennon VA Krecke K | 2006 | Arch Neurol2006，63，： | 1 |
| 11 | Aspiration cytology of pediatric solitary papillary hyperplastic thyroid nodule显示文摘 | K hurana KK Baloch ZW LiVolsi VA | 2001 | Arch Pathol Lab Med2001，25，12： | 1 |
| 12 | Severity of urinaryincontinence and effect on quality of life in women by in-continence type显示文摘 | Minassian VA Devore E Hagan K | 2013 | Obstet Gynecol2013，121，5： | 1 |
| 13 | Improving tribological properties of sputtered boron carbide coatings by process modifications 显示文摘 | Eckardt T Bewilogua K Va der Kolk G | 2000 | Surface & Coatings Technology2000，126，1： | 1 |
| 14 | Stimulation of hepa- tocyte glucose metabolism by novel small molecule glucokinase activators显示文摘 | Brocklehurst K J Payne VA Davies RA | 2004 | Diabetes2004，53，3： | 1 |
| 15 | Inhalative exposure to vanadium pentoxide causes DNA damage in workers:results of a multiple end point study显示文摘 | Ehrlich VA Nersesyan AK Atefie K | 2008 | Environ Health Perspect2008，116，： | 1 |
| 16 | Impaired vasodilator responses in obstructive sleep apnea are im- proved with continuous positive airway pressure therapy 显示文摘 | Imadojemu VA Gleeson K Quraishi SA | 2002 | Am J Respir Crit CareMed2002，165，： | 1 |
| 17 | Endovaginal ultrasound to exclude endometrial cancer and other endometrial abnormalities显示文摘 | Kerlikowsker K Feldstein VA | 1998 | JAMA1998，280，17： | 1 |
| 18 | A viral kinetic study using pegylated interferon alfa-2b and/or lamivudine in patients with chronic hepatitis B/HBeAg negative显示文摘 | Sypsa VA Mimidis K Tassopoulos NC | 2005 | Hepatology2005，42，1： | 1 |
| 19 | Lactic acidosis associated with met- formin use in treatment of type 2 diabetes mellitus 显示文摘 | DePalo VA Mailer K Yoburn D | 2005 | Geriatrics2005，60，： | 1 |
| 20 | Autophagy pro- teins regulate innate immune responses by inhibiting the release of mitoehondrial DNA mediated by the NALP3 inf/ammasome 显示文摘 | Nakahira K Haspel JA Rathinam VA | 2011 | Nat Immunol2011，12，3： | 1 |
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