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| 1 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 2 | Emotion recognition through facial expression analysis based on a neurofuzzy network显示文摘 | Spiros V Ioannou Amaryllis T RaouzAiou Vasilis A Tzouvaras Theofilos P MAilis Kostas C Karpouzis Stefanos D Kollias | 2005 | Neural Networks2005，，： | 1 |
| 3 | Laparoscopic Versus Open Surgery for Rectal Cancer:A Meta-Analysis显示文摘 | Omer A Vasilis C Paris PT | 2005 | Annals of Surgical Oncology2005，13，3： | 1 |
| 4 | Toxic effect of surfactants and probable products of their biodegradation on methanogenesis in an anaerobic microbial community 显示文摘 | Victoria A S Kestutis S L Vasily K A | 1999 | Chemosphere1999，39，11： | 1 |
| 5 | Aldehyde dehydrogenase gene superfamily : the 2002 update 显示文摘 | Sophos N A Vasiliou V | 2003 | Chem B iol Interact2003，14，： | 1 |
| 6 | Advanced computer aided design simulation of gear hobbing by means of three-dimensional kinematics modeling显示文摘 | Vasilis D Nectarios V Aristomenis A | 2007 | Journal of Manufacturing Science and Engineering2007，129，5： | 1 |
| 7 | Effects of two educational method of lecturing and role playing on knowledge and performance of high school students in first aid at emergency scene显示文摘 | Hassanzadeh A Vasili A Zare Z | 2010 | Iranian journal of nursing and midwifery research2010，15，1： | 1 |
| 8 | The effects of rosuvastatin alone or in combination with fenofibrate or omega 3 fatty acids on inflammation and oxidative stress in patients with mixed dyslipidemia显示文摘 | Aris P Agouridis Vasilis Tsimihodimos Theodosios D Filippatos Andromachi A Dimitriou Costantinos C Tellis Moses S Elisaf Dimitri P Mikhailidis Alexandros D Tselepis | 2011 | Expert Opinion on Pharmacotherapy2011，，17： | 1 |
| 9 | Efficiency improvement of AlGaInN LEDs advanced by ray-tracing analysis显示文摘 | Zabelin Vasily Zakheim Dmitri A Gurevich Sergey A | 2004 | IEEE Journal Of Quantum Electronics2004，40，12： | 1 |
| 10 | Rarefaction effects on gas viscosity in the Knudsen transition regime显示文摘 | VASILIS K MICHALIS A N KALARAKIS E D | 2010 | Microfluid Nanofluid2010，9，45： | 1 |
| 11 | Aldehyde dehydrogenase gene superfamily:the 2000 update显示文摘 | Sophos N A Pappa A Ziegler T L Vasiliou V | | 0，，： | 1 |
| 12 | Aldehyde dehydrogenase gene su- perfamily: the 2002 update 显示文摘 | SOPHOS N A VASILIOU V | 2003 | Chem Biol Interact2003，14，： | 1 |
| 13 | Eukaryotic aldehyde dehydrogenase (ALDH) genes:human polymorphisms,and recommended nomenclature based on divergent evolution and chromosomal mapping显示文摘 | Vasiliou V Bairoch A Tipton K F Nebert D W | | 0，，： | 1 |
| 14 | Minimal internal fixation augmented by small wire transfixion frames for high-energy tibial plateau fractures显示文摘 | Katsenis D Vasilis A Panayiotis | 2005 | J Orthop Trauma2005，19，4： | 1 |
| 15 | Laparoscopic Versus Open Surgery for Rectal Cancer : A Meta-Analysis 显示文摘 | Omer A Vasilis C Paris PT | 2005 | Annals of Surgical Oncolo- gy2005，13，3： | 1 |
| 16 | Coronary angioplasty in the elderly: immediate and long-term results显示文摘 | Vasilis V John A Anastasios S | 1993 | Angiology1993，44，： | 1 |
| 17 | Minimal internal fixation augmented by small wire transfixion frames for high-en- ergy tibial plateau fractures 显示文摘 | Katsenis D Vasilis A Panayiotis M | 2005 | JOrthop Trauma2005，19，4： | 1 |
| 18 | Toxic effcet of surfactams and probable products of their biodegradation on methanogenesis in ananaerobic microblal community 显示文摘 | VICFORIA A S KESTUTIS S L VASILY K A | 1999 | Chemosphere1999，39，11： | 1 |
| 19 | Involvement of the electrophile responsive element and p53 in the activation of hepatic stellate cells as a response to etectrophile menadione显示文摘 | Vasiliou V Qamar L Pappa A | 2003 | Arch Biochem Biophys2003，413，： | 1 |
| 20 | 查看详情显示文摘 | Gemma A Vasili H Tanel T | | 0，，： | 1 |
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