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| 1 | Association between polymorphisms in the Toll-like receptor 4,CD14,and CARD15/NOD2and inflammatory bowel disease in the Greek population显示文摘AIM: Crohn's disease(CD)and ulcerative colitis(UC)are multifactorial diseases with a significant genetic background.Apart from CARD15/NOD2 gene, evidence is accumulating that molecules related to the innate immune response such as CD14 or Toll-like receptor 4 (TLR4), are involved in their pathogenesis. In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp,Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.METHODS: DNA was obtained from 120 patients with CD,85 with UC and 100 healthy individuals. Genotyping was performed by allele specific PCR or by PCR-RFLP analysis.RESULTS: The 299Gly allele frequency of the TLR4 gene and the T allele and TT genotype frequendes of the CD14 promoter were significantly higher in CD patients only compared to healthy individuals (P = 0.026<0.05; P = 0.0048<0.01 and P= 0.047<0.05 respectively). Concerning the NOD2/CARD15mutations the overall presence in CD patients was significantly higher than that in UC patients or in controls.Additionally, 51.67% of the CD patients were carriers of a TLR4 and/or CD14 polymorphic allele and at least one variant of the NOD2/CARD15, compared to 27% of the UC patients. It should be pointed out that both frequencies significantly increased as compared with the 10% frequency of multiple carriers found in healthy controls. A possible interaction of the NOD2/CARD15 with TLR4 and especially CD14, increased the risk of developing inflammatory bowel disease (IBD).CONCLUSION: Our results indicate that co-existence of a mutation in either the TLR4 or CD14 gene, and in NOD2/CARD15is associated with an increased susceptibility to developing CD compared to UC, and to developing either CD or UC compared to healthy individuals. | Maria Gazouli Gerassimos Mantzaris Athanassios Kotsinas Panayotis Zacharatos Efstathios Papalambros Athanassios Archimandritis John Ikonomopoulos Vassilis G Gorgoulis | 2005 | World Journal of Gastroenterology2005，11，5： | 17 |
| 2 | LINX^(■) reflux management system to bridge the “treatment gap” in gastroesophageal reflux disease: A systematic review of 35 studies显示文摘BACKGROUND Gastroesophageal reflux disease(GERD) occurs when the reflux of stomach contents causes troublesome symptoms and/or complications. When medical therapy is insufficient, surgical therapy is indicated and, until now, Laparoscopic fundoplication(LF) constitutes the gold-standard method. However, magnetic sphincter augmentation(MSA) using the LINX^® Reflux Management System has recently emerged and disputes the standard therapeutic approach.AIM To investigate the device’s safety and efficacy in resolving GERD symptoms.METHODS This is a systematic review conducted in accordance to the PRISMA guidelines.We searched MEDLINE, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL databases from inception until September 2019.RESULTS Overall, 35 studies with a total number of 2511 MSA patients were included and analyzed. Post-operative proton-pump inhibitor(PPI) cessation rates reached 100%, with less bloating symptoms and a better ability to belch or vomit in comparison to LF. Special patient groups(e.g., bariatric or large hiatal-hernias)had promising results too. The most common postoperative complication was dysphagia ranging between 6% and 83%. Dilation due to dysphagia occurred in 8% of patients with typical inclusion criteria. Esophageal erosion may occur in up to 0.03% of patients. Furthermore, a recent trial indicated MSA as an efficient alternative to double-dose PPIs in moderate-to-severe GERD.CONCLUSION The findings of our review suggest that MSA has the potential to bridge the treatment gap between maxed-out medical treatment and LF. However, further studies with longer follow-up are needed for a better elucidation of these results. | Dimitrios Schizas Aikaterini Mastoraki Eleni Papoutsi Vassilis G Giannakoulis Prodromos Kanavidis Diamantis Tsilimigras Dimitrios Ntourakis Orestis Lyros Theodore Liakakos Dimitrios Moris | 2020 | World Journal of Clinical Cases2020，8，2： | 3 |
| 3 | Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice 显示文摘 | Vassiliou G S Cooper J L Rad R | 2011 | Nat Genet2011，43，5： | 1 |
| 4 | Activation of the DNA damage checkpoint and genomic instability in human pre- cancerous lesions 显示文摘 | Gorgoulis V G Vassiliou L V Karakaidos P | 2005 | Nature2005，434，7035： | 1 |
| 5 | Extended Hopfield models for combinatorial optimization显示文摘 | Vassilis Z | 1999 | IEEE Transactions on Neural Networks1999，10，1： | 1 |
| 6 | Adipocyte low density lipoprotein receptor - related protein gene expression and function is regulated by peroxisome proliferator - activated receptor显示文摘 | Gauthier A Vassiliou G Benoist F | 2003 | J Biol Chem2003，278，11： | 1 |
| 7 | Engrafting costimulator molecules onto tumor cell surfaces with chelator lipids:a potentially convenient approach in cancer vaccine development显示文摘 | van Broekhoven CL Parish CR Vassiliou G | 2000 | J Immunol2000，164，5： | 1 |
| 8 | The low density lipoprotein receptor- related protein contributes to selective uptake of high density lipoprotein cholesteryl esters by SW872 liposarcoma cells and primary human adipocytes显示文摘 | Vassiliou G Benoist F Lau P | 2001 | J Biol Chem2001，276，48： | 1 |
| 9 | Differential ex- pression of osteopontin and bone sialoprotein in bone metastasis of breast and prostate carcinoma显示文摘 | Carlinfante G Vassiliou D Svensson O | 2003 | Clin Exp Metastasis2003，20，5： | 1 |
| 10 | Fundamentals of lap- aroscopic surgery simulator training to proficiency improves laparo- scopic performance in the operating room-a randomized controlled triaJ显示文摘 | Sroka G Feldman LS Vassiliou MC | 2010 | Am J Surg2010，，： | 1 |
| 11 | Noniso- thermal melt-crystallization kinetics for in situ prepared poly (ethy- lene terephthalate)/monmorilonite (PET/OMMT) 显示文摘 | Antoniadis G Paraskevopoulos K M Vassiliou A A | 2011 | Thermo- chimica Acta2011，521，12： | 1 |
| 12 | A multiagent systemenhancing home-care health services for chronic disease management显示文摘 | VASSILIS'G K IOANNA C NICOS M | 2005 | IEEE Trans-Information Technology in Biomedicine2005，9，4： | 1 |
| 13 | Asymptotic behaviour of the survival probabilities in an inhomogeneous semi-Markov model for the migration process in credit risk显示文摘 | VASSILIOU P C G VASILEIOU A | 2013 | Linear Algebra and its Applications2013，438，7： | 1 |
| 14 | Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions 显示文摘 | GORGOULIS V G VASSILIOU L V KARAKAIDOS P | 2005 | Nature2005，434，7035： | 1 |
| 15 | Asymptotic behaviour of the survival probabilities in an inhomogencous scmi-markov model for the migration process in credit risk显示文摘 | Vassiliou P-C G Vasileiou A | 2013 | LinearAlgebra Appl2013，438，7： | 1 |
| 16 | Novel poly (propylene terephthalate-co-succinate)Random copolymers : synthesis, solid structure, and enzymatic degradation study 显示文摘 | Papageorgiou G Z Vassiliou A A Karavelidis V D | 2008 | Macromolecular2008，41，： | 1 |
| 17 | Fundamentals of lap- aroscopic surgery simulator training to proficiency improves laparo- scopic performance in the operating room-a randomized controlled trial显示文摘 | Sroka G Feldman L S Vassiliou M C | 2010 | The American journal of surgery2010，199，1： | 1 |
| 18 | General approach to block-matching motion estimation显示文摘 | Vassilis S Mohammad G | 1993 | Optical Engineering1993，32，7： | 1 |
| 19 | Treatment of real effluents from dyeing reactor: Experimental and modeling approach by adsorption onto chitosan显示文摘 | Kyzas G Z Kostoglou M Vassiliou A A | 2011 | Chemical Engineering Journal2011，168，2： | 1 |
| 20 | Removal of organic contaminants from coal conversion process condensates显示文摘 | Richard G Luthy Vassilis C Stamoudis James R Campbell | 1983 | Journal of Water Pollution Control Federation1983，55，2： | 1 |
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