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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 3 | Heavy metal sorption and desorption capacity of soils containing endogenous contaminants 显示文摘 | COVELO E F VEGA F A ANDRADE M L | 2007 | Journal of Hazardous Materials2007，143，： | 1 |
| 4 | Stress proteins induced by arsenic 显示文摘 | Del Razo L M QuintaniUa - Vega B Brambila - Colom- bres E | 2001 | Toxicology and Applied Pharmacology2001，177，2： | 1 |
| 5 | Graftversus-host disease,an eight case report and literature review 显示文摘 | de la Rosa Garcia E Bologna Molina R Vega Gonzflez Tde J | 2006 | Med Oral Patol Oral Cir Bucal2006，11，6： | 1 |
| 6 | MCP- 1, RANTES, and SDF- 1 polymorphisms in Mexican Patients with systemic lupus erythematosus 显示文摘 | Guadalupe L Soto - Vega E Atisha - Fregoso Y et al | 2007 | Hum Immunol2007，68，： | 1 |
| 7 | Antimicrobial resistance markers of Class 1 and Class 2 integron-bearing Escherichia from irrigation water and sediments显示文摘 | Roe MT Vega E Pillai SD | | 0，，07： | 1 |
| 8 | Autosomal recessive Alport's syndrome and benign familial hematuria are collagen type Ⅳdiseases显示文摘 | Vega BT Badenas C Ars E | 2003 | Am J Kidney Dis2003，42，： | 1 |
| 9 | Infectivity of a bulgarian and an American strain of Steinernema carpocapsae against codling moth显示文摘 | Vega F E Lacey L A Reid A P | | 0，，： | 1 |
| 10 | Acid sensing ionic-channel functional expression in the vestibular endorgans显示文摘 | Vega R Rodríguez U Soto E | 2009 | Neurosci Lett2009，463，3： | 1 |
| 11 | Insect pathology and fungal endophytes显示文摘 | VEGA F E | 2008 | Journal of Invertebrate Pathology2008，98，3： | 1 |
| 12 | Kinetics and mechanism of the reaction of carbon disulfide with piperidine in ethanol显示文摘 | Castro E A Santos G J Vega J C | 1982 | J Org Chem1982，47，19： | 1 |
| 13 | Competitive sorption and desorption of heavy metals by individual soil components显示文摘 | Covelo E F Vega F A Andrade M L | 2007 | Journal of Hazardous Materials2007，140，1： | 1 |
| 14 | Effect of soil recla- mation process on soil C fractions显示文摘 | ASENSIO V VEGA F A COVELO E F | 2014 | Chemosphere2014，95，10： | 1 |
| 15 | Histamine(H3)receptors modulate the excitatory amino acid receptor response of the vestibular afferents显示文摘 | Chavez H Vega R Soto E | 2005 | Brain Res2005，1064，12： | 1 |
| 16 | In -line monitoring of weight average molecular weight in solution polymerizations using intrinsic viscosity measurements显示文摘 | Vega M P Lima E L Pinto J C | 2001 | Polymer2001，42，8： | 1 |
| 17 | Preparation of spherical aggregates of taro starch granules 显示文摘 | Gonzalez-Soto R A Vega B de la Garcia-Suarez F J Agama-Acevedo E | 2011 | LWT-Food Science & Technology2011，44，10： | 1 |
| 18 | Hypocalci- uria during pregnancy as a risk factor of preeclampsia显示文摘 | SEGOVIA B L VEGA I T VILLARREAL E C | 2004 | Ginecol Obstet Mex2004，72，： | 1 |
| 19 | Deriving ecological risk based soil quality values in the Basque County显示文摘 | Urzela IA Vega M Angulo E | 2000 | The Science of the Total Environment2000，247，2： | 1 |
| 20 | Localization of mineral uptake by roots using Sr isotopes 显示文摘 | Dambrine E Loubet M Vega J A | 1997 | Plant and Soil1997，192，1： | 1 |
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