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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | Neurosurgical outcomes after intracerebral hemorrhage:results of the factor seven for acute hemorrhagic stroke trial(FAST)显示文摘 | Steiner T Vincent C Morris S | 2011 | J Stroke Cerebrovasc Dis2011，20，4： | 1 |
| 3 | Influence of carbide coatings on the oxidation behavior of carbon fibers显示文摘 | Piquero T Vincent H Vincent C | 1995 | Carbon1995，33，1： | 1 |
| 4 | High-throughput solution processing of large-scale graphene显示文摘 | Vincent C T Matthew J A Yang Y | 2009 | Nature Nano technology2009，4，： | 1 |
| 5 | Importance of the forest canopy to flux of methylmercury and total mercury to boreal ecosystems显示文摘 | Vincent L Louis S T John W M Kelly C A | 2001 | Environmental Science and Technology2001，35，： | 1 |
| 6 | Using vanishing points for camera calibratian显示文摘 | Bruno C Vincent T | 1990 | Computer Vision1990，4，2： | 1 |
| 7 | FRP-confined concrete in circular sections:Review and assessment of stress-strain models显示文摘 | Ozbakkaloglu T Jian C L Vincent T | 2013 | 49(2):1068-10882013，49，2： | 1 |
| 8 | The prolactin receptorgane is aasociated with increased litter size in pig显示文摘 | Evans G Shoa T H Southwood O I Plastow GS Tuggle C K and Rothschild M F | 1998 | Proceedings of the 6 th Wodd Congress on Genetics Applied to Livestock Production1998，27，： | 1 |
| 9 | Dynamics of spider colonization of apple orchards from adjacent deciduous forest显示文摘 | Sackett T E Buddle C M Vincent C | 2008 | Agriculture Ecosystems and Environment2008，129，1： | 1 |
| 10 | Neurosurgical outcomes after intracere- bral hemorrhage: results of the factor seven for acute hemorrhagic stroke trial (FAST) 显示文摘 | Steiner T Vincent C Morris S | 2011 | J Stroke Cerebrovase Dis2011，204，： | 1 |
| 11 | Neurosurgical outcomes after intraeerebral hemorrhage= results of the factor seven for acute hemorrhagic stroke trial (FAST) 显示文摘 | Steiner T Vincent C Morris S et aI | 2011 | J Stroke Cerebro- vase Dis2011，20，4： | 1 |
| 12 | Long-acting somatostatinanalogues decrease blood transfusion requirements in patients withrefractory gastrointestinal bleeding associated with angiodysplasia显示文摘 | Bon C Aparicio T Vincent M | 2012 | Aliment Pharmacol Ther2012，36，6： | 1 |
| 13 | Dose Planning Study of Target Volume Coverage with Intensity - Modulated Radio- therapy for Nasopharyngeal Carcinoma: Penang General Hospital Ex- perience显示文摘 | Vincent P C E Boon Seang T Ai Lian T | 2013 | Asian Pacific Journal of Cancer Prevention Apjcp2013，14，4： | 1 |
| 14 | Roughness Measurement of Metallic Surfaces Based on the Laser Speckle Contrast Method 显示文摘 | Lisa C L Vincent T | 1998 | Optics and Lasers in Engineering1998，30，： | 1 |
| 15 | Neurosurgical outcomes after in- tracerebral hemorrhage : results of the factor seven foracute hemorrhag- ic stroke trial (FAST) 显示文摘 | Steiner T Vincent C Morris S | 2010 | J Stroke Cerebro vasc Dis2010，20，： | 1 |
| 16 | Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA -induced Ca^2+ sensitization of contraction in vascular smooth muscle显示文摘 | Vincent S Helene L J Chrystelle C T | 2000 | J Bio Chem2000，275，21： | 1 |
| 17 | A benchmark problem for nonlinear control design 显示文摘 | ROBERT T B DENNIS S B VINCENT T C | 1998 | International Journal of Robust and Nonlinear Control1998，8，4： | 1 |
| 18 | Prevalence, mecha- nisms, and risk factors of carbapenem resistance in blood- stream isolates of Pseudornonas aeruginosa 显示文摘 | Vincent H Kai-Tai C Mark T | 2007 | Diagn Micro biol Infect Dis2007，58，： | 1 |
| 19 | Management of spent solvents by alkaline hydrolysis process显示文摘 | Manohar S Srinivas C Vincent T | 1999 | Waste Management1999，19，： | 1 |
| 20 | Neurosurgical outcomes after intracerebral hemorrhage:results of the fact or s even f or acute hemorrhagic stroke trial(FAST) 显示文摘 | Steiner T Vincent C Morris S | 2010 | Stroke Cere- brovasc Dis2010，32，16： | 1 |
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