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| 1 | Prediction of atrial fibrillation development and progression:current perspectives显示文摘Atrial fibrillation(AF) is the most common arrhythmia in clinical practice. Several conventional and novel predictors of AF development and progression(from paroxysmal to persistent and permanent types) have been reported. The most important predictor of AF progression is possibly the arrhythmia itself. The electrical, mechanical and structural remodeling determines the perpetuation of AF and the progression from paroxysmal to persistent and permanent forms. Common clinical scores such as the hypertension, age ≥ 75 years, transient ischemic attack or stroke, chronic obstructive pulmonary disease, and heart failure and the congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category scores as well as biomarkers related to inflammation may also add important information on this topic. There is now increasing evidence that even in patients with so-called lone or idiopathic AF, the arrhythmia is the manifestation of a structural atrial disease which has recently been defined and described as fibrotic atrial cardiomyopathy. Fibrosis results from a broad range of factors related to AF inducing pathologies such as cell stretch, neurohumoral activation, and oxidative stress. The extent of fibrosis as detected either by late gadolinium enhancement-magnetic resonance imaging or electroanatomic voltage mapping may guide the therapeutic approach based on the arrhythmia substrate. The knowledge of these risk factors may not only delay arrhythmia progression, but also reduce the arrhythmia burden in patients with first detected AF. The present review highlights on the conventional and novel risk factors of development and progression of AF. | Konstantinos Vlachos Konstantinos P Letsas Panagiotis Korantzopoulos Tong Liu Stamatis Georgopoulos Athanasios Bakalakos Nikolaos Karamichalakis Sotirios Xydonas Michael Efremidis Antonios Sideris | 2016 | World Journal of Cardiology2016，8，3： | 16 |
| 2 | Simple hematological predictors of AF recurrence in patients undergoing atrial fibrillation ablation显示文摘Backgound Red cell distribution width(RDW) and neutrophil-to-lymphocyte ratio(NLR) are simple hematologic indices that have been used to predict adverse outcomes in different clinical settings. The aim of our study is to determine whether RDW and NLR can predict atrial fibrillation(AF) recurrence in patients undergoing AF ablation. Methods Consecutive patients, without known hematological disorders, who underwent AF catheter ablation between January 2014 and April 2017 were enrolled into this study. Blood samples were taken one day before and five hours after the ablation procedure. Results A total of 346 patients(224 males(65%), mean age: 59 ± 11 years old) were included. After a mean follow up of 26.2 ± 12.1 months, 80(23.1%) patients experienced late AF recurrence(defined as any recurrence after the blanking period of three months), while 97(28%) patients experienced early AF recurrence during the blanking period. Univariate analysis showed that early arrhythmia recurrence, type of AF and NLR after the procedure were significantly associated with late AF recurrence, while early arrhythmia recurrence and NLR remained significant in multivariate analysis. RDW was not associated with late AF recurrence. None of the parameters above predicted early arrhythmia recurrence. Conclusions Simple and inexpensive hematological indices such as NLR should be evaluated for their ability to predict AF recurrence in patients undergoing catheter ablation in larger prospective studies. | George Bazoukis Konstantinos P Letsas Konstantinos Vlachos Athanasios Saplaouras Dimitrios Asvestas Konstantinos Tyrovolas Aikaterini Rokiza Eirini Pagkalidou Gary Tse Stavros Stavrakis Antonios Sideris Michael Efremidis | 2019 | Journal of Geriatric Cardiology2019，16，9： | 4 |
| 3 | Headache:An unusual presentation of acute myocardial infraction显示文摘Acute myocardial infarction should be diagnosed as early as possible for the appropriate management to salvage ischemic myocardium. Accurate diagnosis is typically based on the typical symptoms of angina. Headache is an unusual symptom in patients with acute myocardial infraction. We report a patient with ST-segment elevation acute myocardial infarction who presented to the emergency department complaining of severe occipital headache without chest discomfort. | Dimitrios Asvestas Konstantinos Vlachos Anastasios Salachas Konstantinos P Letsas Antonios Sideris | 2014 | World Journal of Cardiology2014，6，6： | 3 |
| 4 | Efficacy and safety of novel anticoagulants in the elderly显示文摘Atrial 纤维性颤动和静脉的 thromboembolism (VTE ) 是与有害 thrombotic 事件联系的普通混乱,特别地在老病人。Polypharmacy,合作病态,和改变的 pharmacokinetics,在这些病人经常在场,使抗凝剂的使用变为相当挑战性。新奇口头的抗凝剂(NOAC ) 最近作为维生素 K 对手(VKA ) 的选择出现了并且主要因为他们的更少药和食物相互作用和容易使用,逐渐地正在增加他们的流行。他们的有效性和安全在一般人口是生长得很好的但是在利益和伤害在之间的平衡老仍然是不清楚的。在这些病人的平淡的使用是不平常的。积累的数据证明了 NOAC 的利益在所有年龄组之中是一致的,展示在阻止 thrombotic 事件的相等或更大的功效。过量流血与与 VKA 相比的 NOAC 是更低的,但是为模式放血在他们之中并且面对面是迥异的比较不是可得到的。在老人口的新奇抗凝剂的功效和安全上的现在的评论热点。 | Nikolaos Karamichalakis Stamatis Georgopoulos Konstantinos Vlachos Ioarmis Liatakis Michael Efremidis Antonios Sideris Konstantinos P Letsas | 2016 | Journal of Geriatric Cardiology2016，13，8： | 3 |
| 5 | Corporate Social Responsibility:Attributions, Loyalty and the Mediating Role of Trust 显示文摘 | Pavlos A Vlachos Argiris Tsamakos Adam P Vrechopoulos Panagiotis K Avramidis | 2009 | Journal of the Academy of Marketing Science2009，，37： | 1 |
| 6 | Corporate Social Responsibility : Attributions, Loyalty, and the Mediating Role of Trust 显示文摘 | Vlachos P A Tsamakos A Vrechopoulos A P | 2009 | Jour- nal of the Academy of Marketing Science2009，37，2： | 1 |
| 7 | The effect of environmental parameters on product recovery显示文摘 | Georgiadis P Vlachos D | | 0，，： | 1 |
| 8 | Round gas jets submerged in water显示文摘 | Weiland C Vlachos P P | 2013 | International Journal of Muhiphase Flow2013，48，： | 1 |
| 9 | The Effect of Humidity on Tin-Oxide Thick-Film Gas Sensors in the Presence of Reducing and Combustible Gases 显示文摘 | Vlachos D S Skafidas P D Avafitsiutis J N | 1995 | Sensors and Actuators B1995，2425，： | 1 |
| 10 | Full-length p73a represses drug-induced apoptosis in small cell lung car- cinoma cells显示文摘 | Nyman U Sobczak-Pluta A Vlachos P | 2005 | J Biol Chem2005，280，34： | 1 |
| 11 | The cell cycle inhibitor p57 (Kip2) promotes cell death via the mitochondrial apoptotic pathway显示文摘 | Vlachos P Nyman U Hajji N Joseph B | 2007 | Cell Death Differ2007，14，8： | 1 |
| 12 | A System Dynamics Model for Dynamic Capacity Planning of Remenufacturing in Closed-loop Supply Chains 显示文摘 | Vlachos D Georgiadis P Iakovou E | 2007 | Computers & Operations Research2007，，34： | 1 |
| 13 | The Cdk inhibitor p57(Kip2) controls LIM- kinase 1 activity and regulates aetin eytoskeleton dynamics 显示文摘 | Vlachos P Joseph B | 2009 | Oncogene2009，28，47： | 1 |
| 14 | Corpo- rate Social Responsibility: Attributions, Loyalty, and the Me- diating Role of Trust 显示文摘 | Vlachos P A Tsamakos A Verchopoulos A P | 2009 | Journal of Academy of Marketing Science2009，37，2： | 1 |
| 15 | Catheter ablation of persistent atrial fibrillation:The importance of substrate modification显示文摘Accumulating data have shown that elimination of atrial fibrillation(AF) sources should be the goal in persistent AF ablation. Pulmonary vein isolation, linear lesions and complex fractionated atrial electrograms(CFAEs) ablation have shown limited efficacy in patients with persistent AF. A combined approach using voltage, CFAEs and dominant frequency(DF) mapping may be helpful for the identification of AF sources and subsequent focal substrate modification. The fibrillatory activity is maintained by intramural reentry centered on fibrotic patches. Voltage mapping may assist in the identification of fibrotic areas. Stable rotors display the higher DF and possibly drive AF. Furthermore, the single rotor is usually consistent with organized AF electrograms without fractionation. It is therefore quite possible that rotors are located at relatively 'healthy islands' within the patchy fibrosis. This is supported by the fact that high DF sites have been negatively correlated to the amount of fibrosis. CFAEs are located in areas adjacent to high DF. In conclusion, patchy fibrotic areas displaying the maximum DF along with high organization index and the lower fractionation index are potential targets of ablation. Prospective studies are required to validate the efficacy of substrate modification in left atrial ablation outcomes. | Konstantinos P Letsas Michael Efremidis Nikolaos P Sgouros Konstantinos Vlachos Dimitrios Asvestas Antonios Sideris | 2015 | World Journal of Cardiology2015，7，3： | 1 |
| 16 | Concept analysis and laboratory observations on a water piercing missile launcher显示文摘 | Weiland C J Vlachos P P Yagla J J | | 0，，： | 1 |
| 17 | Seram and cerebrospinal fluid concentrations of linezolid in neurosurgical patients显示文摘 | Myrianthefs P Markantonis S Vlachos K | 2006 | Antimicrob Agents Chemother2006，50，12： | 1 |
| 18 | A System Dynamics Model for Dynamic Capacity Planning of Remanufacturing in Closed-loop Supply Chains显示文摘 | Vlachos D Georgiadis P Iakovou E | 2007 | Computers & Operations Research2007，34，2： | 1 |
| 19 | Consumer-retailer love and attachment显示文摘 | VLACHOS P A VRECHOPOULOS A P | 2012 | Journal of retailing and consumer services2012，19，2： | 1 |
| 20 | The effect of free surface on the vortex shedding from inclined cir- cular cylinder 显示文摘 | Vlachos P P Telionis D P | 2008 | Journal of Fluid Engineering2008，130，2： | 1 |
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