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| 1 | Trans-arterial chemoperfusion for the treatment of liver metastases of breast cancer and colorectal cancer: Clinical results in palliative care patients显示文摘AIM To evaluate the clinical value and efficiency of transarterial chemoperfusion(TACP) in patients with liver metastases from breast cancer(BC) and colorectal cancer(CRC).METHODS We treated 36 patients with liver metastases of BC(n = 19, 19 females) and CRC(n = 17; 8 females, 9 males) with repeated TACP. The treatment interval was 4 wk. TACP was performed with gemcitabine(1000 mg/m2) and mitomycin(10 mg/m2), administered within 1 h after positioning the catheter tip in the hepatic artery. Before treatment, the size, location, tumour volume, vascularization and number of liver tumours were evaluated using magnetic resonance imaging(MRI). Tumour response was evaluated according to the Response Evaluation Criteria in Solid Tumors guidelines.RESULTS TACP using gemcitabine and mitomycin for metastases from CRC and BC was performed without any serious side effects. The follow-up MRI showed a therapeutic response in 84.2% of the BC patients-stable disease 47.4% and partial response 36.8%. A progression was seen in 15.8%.CRC patients showed a therapeutic response in 52.9% of cases. A progression of the disease was documented in 47.1% of the patients with CRC. These data show that TACP in patients with liver metastases of BC leads to a significantly better therapeutic response compared with CRC patients(P = 0.042). The median survival time was 13.2 mo for the BC patients, which is significantly longer than for CRC patients at 9.3 mo(P = 0.001).CONCLUSION TACP for liver metastases of BC appears to be a safe and effective palliative treatment with improved outcomes in comparison to patients with CRC. | Tatjana Gruber-Rouh Marcel Langenbach Nagy NN Naguib Nour-Eldin M Nour-Eldin Thomas J Vogl Stephan Zangos Martin Beeres | 2017 | World Journal of Clinical Oncology2017，8，4： | 7 |
| 2 | Association between facet joint osteoarthritis and the Oswestry Disability Index显示文摘AIM:To investigate the correlation of facet joint osteoarthritis(FJOA) at lumbar levels L4/L5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS:The study involved lumbar MRIs of 591 patients with a mean age of 47.3 years.The MRIs of the lumbar spine were performed on a 1.5 Tesla scanner(Magnetom Avanto,Siemens AG,Erlangen,Germany) using a dedicated receive only spine coil.After initial blinding,each dataset was evaluated by 2 board certified radiologist with more than 5 years experience in musculoskeletal imaging.In total 2364 facet joints were graded.Degenerative changes of the facet joints were evaluated according to the 4-point scale as proposed by Weishaupt et al Functional status was assessed using the ODI.The index is scored from 0 to 100 and interpreted as follows:0%-20%,minimaldisability; 20%-40%,moderate disability; 40%-60%,severe disability; 60%-80%,crippled; 80%-100%,patients are bedbound.Spearman's coefficient of rank correlation was used for statistical analysis,with significance set at P < 0.05.RESULTS:In total 2364 facet joints at lumbar levels L4/5 and L5/S1 were analysed in 591 individuals.FJOA was present in 97%(L4/L5) and 98%(L5/S1).At level L4/5(left/right) 17/15(2.9%/2.5%) were described as grade 0,146/147(24.7%/24.9%) as grade 1,290/302(49.1%/51.1%) as grade 2 and 138/127(23.4%/21.5%) as grade 3.At level L5/S1(left/right) 10/11(1.7%/1.9%) were described as grade 0,136/136(23.0%/23.0%) as grade 1,318/325(53.8%/55.0%) as grade 2 and 127/119(21.5%/20.1%) as grade 3.Regarding the ODI scores,patients' disability had a minimum of 0% and a maximum of 91.11% with an arithmetic mean of 32.77% ± 17.02%.The majority of patients(48.39%) had moderate functional disability(21%-40%).There was no significant correlation between FJOA and ODI on both sides of lumbar level L4/5 and on the left side of lumbar level L5/S1.A weak positive correlation was evaluated between ODI and FJOA on the right side of lumbar level L5/S1.CONCLUSION:The missing correlation of FJOA and ODI confirms our clinical experience that imaging alone is an insufficient approach explaining low back pain.Clinical correlation is imperative for an adequate diagnostic advance in patients with low back pain. | Adel Maataoui Thomas J Vogl Marcus Middendorp Konstantinos Kafchitsas M Fawad Khan | 2014 | World Journal of Radiology2014，6，11： | 6 |
| 3 | Correlation of lumbar lateral recess stenosis in magnetic resonance imaging and clinical symptoms显示文摘AIM To assess the correlation of lateral recess stenosis(LRS) of lumbar segments L4/5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS Nine hundred and twenty-seven patients with history of low back pain were included in this uncontrolled study.On magnetic resonance images(MRI) the lateral recesses(LR) at lumbar levels L4/5 and L5/S1 were evaluated and each nerve root was classified into a 4-point grading scale(Grade 0-3) as normal,not deviated,deviated or compressed.Patient symptoms and disability were assessed using ODI.The Spearman's rank correlation coefficient was used for statistical analysis(P < 0.05).RESULTS Approximately half of the LR revealed stenosis(grade 1-3;52% at level L4/5 and 42% at level L5/S1) with 2.2% and 1.9% respectively reveal a nerve root compression.The ODI score ranged from 0%-91.11% with an arithmetic mean of 34.06% ± 16.89%.We observed a very weak statistically significant positive correlation between ODI and LRS at lumbar levels L4/5 and L5/S1,each bilaterally(L4/5 left:rho < 0.105,P < 0.01;L4/5 right:rho < 0.111,P < 0.01;L5/S1 left:rho 0.128,P < 0.01;L5/S1 right:rho < 0.157,P < 0.001).CONCLUSION Although MRI is the standard imaging tool for diagnosing lumbar spinal stenosis,this study showed only a weak correlation of LRS on MRI and clinical findings.This can be attributed to a number of reasons outlined in this study,underlining that imaging findings alone are not sufficient to establish a reliable diagnosis for patients with LRS. | Annina SplettstoBer M Fawad Khan Bernd Zimmermann Thomas J Vogl Hanns Ackermann Marcus Middendorp Adel Maataoui | 2017 | World Journal of Radiology2017，9，5： | 4 |
| 4 | Magnetic resonance imaging-based interpretation of degenerative changes in the lower lumbar segments and therapeutic consequences显示文摘Intervertebral disc degeneration and facet joint osteoarthritis of the lumbar spine are, among others, wellknown as a cause of low back and lower extremity pain. Together with their secondary disorders they set a big burden on health care systems and economics worldwide. Despite modern imaging modalities, such as magnetic resonance imaging, for a large proportion of patients with low back pain(LBP) it remains difficult to provide a specific diagnosis. The fact that nearly all the lumbar structures are possible sources of LBP, may serve as a possible explanation. Furthermore, our clinical experience confirms, that imaging alone is not a sufficient approach explaining LBP. Here, the Oswestry Disability Index, as the most commonly used measure to quantify disability for LBP, may serve as an easy-toapply questionnaire to evaluate the patient's ability to cope with everyday life. For therapeutic purposes, among the different options, the lumbar facet joint intraarticular injection of corticosteroids in combination with an anaesthetic solution is one of the most frequently performed interventional procedures. Although widely used the clinical benefit of intra-articular steroid injections remains controversial. Therefore, prior to therapy, standardized diagnostic algorithms for an accurate assessment, classification and correlation of degenerative changes of the lumbar spine are needed. | Adel Maataoui Thomas J Vogl M Fawad Khan | 2015 | World Journal of Radiology2015，7，8： | 4 |
| 5 | The decoration of carbon nanotube by metal nanoparticles显示文摘 | Satishkumar B C Vogl E M Govindaraj A | 1996 | J Phys D:Apple Phys1996，29，： | 1 |
| 6 | Materials research 显示文摘 | Satishkuma B C Govindaraj A Vogl E M | 1997 | J Mater Res1997，12，： | 1 |
| 7 | Serun levels ofpregnenolone and 17-hydroxypregnenolone in patients with rheumatoid arthritis and systemic lupus erythematosus: relation to other adrenal hormones 显示文摘 | Vogl D Falk W Domer M | 2003 | J Rheumatol2003，30，2： | 1 |
| 8 | Noninvasive monitoring using serum amyloid A and serum neopterin in cardiac transplantation 显示文摘 | Muller T F Vogl M Neumann M C | 1998 | Clin Chim Acta1998，276，1： | 1 |
| 9 | Parotid space; plain and gadolinium-enhanced MR imaging显示文摘 | Vogl T J Dresel S H Spath M | 1990 | Radiology1990，177，3： | 1 |
| 10 | Effect of Chemical Fluorination of Carbon Anodes Electrochemical Properties in KF-2HF 显示文摘 | GROULT H DEVILLIERS D VOGLE M | 1997 | J Electrochem Soc1997，144，10： | 1 |
| 11 | The use of silicon nitride in buried contact solar cells显示文摘 | Vogl B Slade A M Pritchard S C | 2001 | Solar Energy Materials & Solar Cells2001，66，： | 1 |
| 12 | Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritis显示文摘 | Frosch M Vogl T Seeliger S | 2003 | Arthritis Rheum2003，48，9： | 1 |
| 13 | Oxide nanotubes prepared using carbon nanotubes as templates显示文摘 | Satishkumar B C Govindaraj A Vogl E M | 1997 | Mater Res1997，12，3： | 1 |
| 14 | Transarterial chemoembolization for hepatocellular carcinoma:volumetric and morphologic CT criteria for assessment of prognosis and therapeutic success-results from a liver transplantation center显示文摘 | Vogl T J Trapp M Schroeder H | 2000 | Radiology2000，214，2： | 1 |
| 15 | Multislice CT and CT angiography for non-invasive evaluation of bronchopulmonary sequestration显示文摘 | Ahmed M Jacobi V Vogl T J | | 0，，： | 1 |
| 16 | Bioceram- ic vertebral augmentation with a calcium sulphate / hydroxyapatite composite ( Cerament Spine Support) : in vertebral compression fractures due to osteoporosis 显示文摘 | Rauschmann M Vogl T Verheyden A | 2010 | Eur Spine J2010，19，6： | 1 |
| 17 | Can thrombin-activated platelet releasate compensate the age-induced decrease in cell proliferation of MSC?显示文摘 | Vogl M Fischer J J(a)ger M | 2013 | J Orthop Res2013，31，11： | 1 |
| 18 | Interventional MR: interstitial therapy显示文摘 | T. J. Vogl M. G. Mack P. K. Müller R. Straub K. Engelmann K. Eichler | 1999 | European Radiology1999，，8： | 1 |
| 19 | The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleu- kin-1 beta form a positive feedback mechanism in systemic-onset ju- venile idiopathic arthritis 显示文摘 | Frosch M Ahlmann M Vogl T | 2009 | Arthritis Rheum2009，60，3： | 1 |
| 20 | Parotid space: plain and gadolinium-enhanced MR imaging显示文摘 | Vogl TJ Dresel SH Spath M | 1990 | Radiology1990，177，3： | 1 |
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