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| 1 | 破裂动脉瘤-栓塞或夹闭疗效相当(英文)显示文摘In the May 2009 issue of The Lancet Neurology,the 5-year follow-up results of the International Subarachnoid Aneurysm Trial(ISAT) were published.The authors concluded that,although the significant difference between coiling and neurosurgical clipping of ruptured intracranial aneurysms in terms of death and severe disability after 1 year has vanished(primary endpoint),coiling should still be favored over neurosurgical clipping because mortality rates significantly favored coiling.In this commentary,it is this particular conclusion that is challenged by combining data from previous ISAT publications with the current 5-year follow-up results.This modified intent-to-treat analysis clearly demonstrates that the significant advantage in terms of mortality in favor of the endovascularly treated patients is no longer present,with a hazard ratio of 0.80 in favor of endovascular treatment(95% confidence interval: 0.60-1.05;P =.10).Therefore,for everyday clinical practice and decision making,coiling and clipping are to be considered equivalent in the long term. | Bakker NA Metzemaekers JD Groen RJ Mooij JJ Van Dijk JM | 2010 | 中华神经外科疾病研究杂志2010，9，3： | 41 |
| 2 | Emerging roles of the intestine in control of cholesterol metabolism显示文摘The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels. | Janine K Kruit Albert K Groen Theo J van Berkel Folkert Kuipers | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 3 | Pulmonary Angiogenesis in a Rat Model of Hepatopulmonary Syndrome显示文摘 | Junlan Zhang Bao Luo Liping Tang Yongming Wang Cecil R. Stockard Inga Kadish Thomas Van Groen William E. Grizzle Selvarangan Ponnazhagan Michael B. Fallon | 2009 | Gastroenterology2009，，3： | 2 |
| 4 | Morphology of the human internal vertebral venous plexus:a cadaver study after intravenous Araldite CY 221 injection显示文摘 | Groen RJ Groenewegen HJ Van Alphen HA | 1997 | Anat Rec1997，249，2： | 1 |
| 5 | Surgical clipp- ing as the preferred treatment for aneurysms of the middle cerebral artery 显示文摘 | van Dijk JM Groen RJ Ter Laan M | 2011 | Acta Neurochir (Wien)2011，153，11： | 1 |
| 6 | A newly discov-ered human pneumovirus isolated from young children with respiratorytract disease显示文摘 | Van Den Hoogen BG De Jong JC Groen J | 2001 | Nat Med2001，7，6： | 1 |
| 7 | A newly discovered human pneumovirus isolated from young children with respiratory tract disease显示文摘 | van den Hoogen BG de Jong JC Groen J | 2001 | Nat Med2001，7，6： | 1 |
| 8 | Use of recombinant nucleoproteins in enzyme-linked immunosorbent assays for detection of virus-specific immunoglobulin A or B infected patients显示文摘 | Voeten J T Groen J Van Alphen D | 1998 | J Clin Microbiol1998，36，12： | 1 |
| 9 | Randomised trial of endo- scopic balloon dilation versus endoscopic sphineterotomy for re- moval of bileduct stones显示文摘 | Bergman JJ Van Berkel AM Groen AK | 1997 | Lancet1997，349，9059： | 1 |
| 10 | A newly discovered human pneumovirus isolated from young respiratory tract disease 显示文摘 | van den Hoogen BG de Jong JC Groen J | 2001 | Nat Med2001，7，6： | 1 |
| 11 | Respiratory syncytial virus specific serum antibodies in infants under sixmonths of age:limited serological response upon infection显示文摘 | BRANDENBURG A H GROEN J VAN STEENSEL-MOLL H A | 1997 | Med Virol1997，52，1： | 1 |
| 12 | The prognostic value of histology in the assessment of patients with Budd–Chiari syndrome显示文摘 | Thjon J Tang Kenneth P Batts Piet C de Groen Bart van Hoek Elizabeth B Haagsma Wim C.J Hop Harry L.A Janssen | 2001 | Journal of Hepatology2001，，3： | 1 |
| 13 | A newlydiscovered human pneumovirus isolated from young childrenwith respiratory tract disease显示文摘 | van den Hoogen BG de Jong JC Groen J | 2001 | Nat Med2001，7，： | 1 |
| 14 | A newly discovered human pneum ovirus isolated from young children with respiratory tract disease显示文摘 | Van den Hoogen B G de Jong J C Groen J | 2001 | Nat Med2001，7，6： | 1 |
| 15 | A newly discovered human pneumovirus isolated from young children with respi- ratory tract disease 显示文摘 | VAN DEN HOOGEN BG DE JONG JC GROEN J | 2001 | Nature Med2001，7，6： | 1 |
| 16 | Microsatellite polymorphism in commercial broiler and layer lines estimated using pooled blood samples显示文摘 | Crooijmans R P Groen A F Van Kampen A J | 1996 | Poultry Science1996，75，7： | 1 |
| 17 | Guest editors introduction:entrepreneurship's role in commercializing disruptive technologies显示文摘 | GROEN A SIJDE VAN DER P WALSH S | 2008 | International Small Business Journal2008，26，1： | 1 |
| 18 | Plaque rapture in the carotid artery is localized at the high shear stress region: acase report显示文摘 | Groen HC Gijsen FJ van der Lugt A | 2007 | Stroke2007，38，8： | 1 |
| 19 | Operative treatment of spontaneous spinal epidural hematomas:a study of the factors determing postoperative outcome显示文摘 | Groen RJ van Alphen HA | 1996 | Neurosurgery1996，39，： | 1 |
| 20 | A newly discovered human pneumovirus isolated from young children with respiratory tract disease 显示文摘 | van den Hoogen B G de Jong J C Groen J | 2001 | Nat Med2001，7，6： | 1 |
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