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| 1 | 破裂动脉瘤-栓塞或夹闭疗效相当(英文)显示文摘In the May 2009 issue of The Lancet Neurology,the 5-year follow-up results of the International Subarachnoid Aneurysm Trial(ISAT) were published.The authors concluded that,although the significant difference between coiling and neurosurgical clipping of ruptured intracranial aneurysms in terms of death and severe disability after 1 year has vanished(primary endpoint),coiling should still be favored over neurosurgical clipping because mortality rates significantly favored coiling.In this commentary,it is this particular conclusion that is challenged by combining data from previous ISAT publications with the current 5-year follow-up results.This modified intent-to-treat analysis clearly demonstrates that the significant advantage in terms of mortality in favor of the endovascularly treated patients is no longer present,with a hazard ratio of 0.80 in favor of endovascular treatment(95% confidence interval: 0.60-1.05;P =.10).Therefore,for everyday clinical practice and decision making,coiling and clipping are to be considered equivalent in the long term. | Bakker NA Metzemaekers JD Groen RJ Mooij JJ Van Dijk JM | 2010 | 中华神经外科疾病研究杂志2010，9，3： | 41 |
| 2 | Co-localization hypothesis:A mechanism for the intrapancreatic activation of digestive enzymes during the early phases of acute pancreatitis显示文摘尖锐胰腺炎通常被相信是胰被它通常生产的消化酶在伤害的疾病。当是的不活跃的酶原通常仅仅在入口之上激活进十二指肠,但是在尖锐胰腺炎的早阶段期间,那些酶原变得过早地在胰以内并且,大概激活,大多数胰腺的腺泡房间生产的潜在地有害的消化酶被综合并且藏匿那激活发生在胰腺的腺泡房间以内。为消化酶酶原的细胞内部的激活负责的机制没与必然被阐明,但是根据一个广泛地公认的理论(“合作本地化假设”) ,消化酶酶原被 lysosomal 水疗院激活当酶的二种类型在一样的细胞内部的分隔空间以内变得 co 局部性时,放射激光。这评论集中于在胰腺炎的早阶段期间作为对消化酶激活的解释支持合作本地化假设的有效性的证据。调查结果,在这评论总结了,支持 lysosomal 水疗院的合作本地化与消化酶酶原戏放射激光的结论在允许导致腺泡房间损害和胰腺炎的消化酶的细胞内部的激活的一个关键角色。 | Gijs JD van Acker George Perides Michael L Steer | 2006 | World Journal of Gastroenterology2006，12，13： | 10 |
| 3 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 4 | Essential fatty acid status in neonates after fish-oil supplementation during late pregnancy显示文摘 | Van Houwelingen AC S φrensen JD Hornstra G | 1995 | Brit J Nutr1995，74，： | 2 |
| 5 | The efficacy of phytase in corn-soybean meal-based diets for laying hens显示文摘 | Van der Klis JD | 1997 | Poult Sci1997，76，： | 2 |
| 6 | Bladder-sphincter dysfunction in myelomeningocele 显示文摘 | van Gool JD Dik P de Jong TP | 2001 | Eur J Pediatr2001，160，7： | 1 |
| 7 | Longterm recurrent subarachnoid hemorrhage after adequate coiling versus clipping of ruptured intracranial aneurysms 显示文摘 | Schaafsma JD Sprengers ME van Rooij W J | 2009 | Strok2009，40，： | 1 |
| 8 | Visual analog scale (VAS) for assessment of acute mountain sickness (AMS) on Aconca~,ua 显示文摘 | Van Roo JD Lazio MP Pesce C | 2011 | Wilderness Environ Med2011，22，1： | 1 |
| 9 | Calcineurin and hypertrophic heart disease: novel insights and remaining questions显示文摘 | Bueno OF van Rooij E Molkentin JD | 2002 | Cardiovasc Res2002，53，4： | 1 |
| 10 | Orbital hemangiopericytoma and solitary fibrous tumor: a morphologic continuum显示文摘 | Goldsmith JD van de Riji M Syed N | 2001 | Int J Surg Pathol2001，9，4： | 1 |
| 11 | Molecular characterization of the plasmid-encoded eps gene clusler essential for exopolysaccharide biosynthesis in Lactococcus lactis显示文摘 | Van Kranenburg R Marugg JD van Swam I1 | 1995 | Mol Microbiol1995，24，： | 1 |
| 12 | A review of fine root dynamics in Populus plantations显示文摘 | Block RMA van Rees KCJ Knight JD | | 0，，： | 1 |
| 13 | Impaired emotion recognition in music in Parkinson,s disease显示文摘 | van Tricht MJ Smeding HM Speelman JD | 2010 | Brain Cogn2010，74，1： | 1 |
| 14 | Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology显示文摘 | Van Embden JD Cave MD Crawford JT | 1993 | J Clin Microbiol1993，31，2： | 1 |
| 15 | Endothelial signaling by Ig like cell adhesion molecules 显示文摘 | van Buul JD Kanters E Hordijk PL | 2007 | Arterioscler Thromb Vase Biol2007，27，9： | 1 |
| 16 | Loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition 显示文摘 | van der Aar AM Sylva-SteenLand RM Bos JD | 2007 | J Immunol2007，178，4： | 1 |
| 17 | Evaluation of contraindications and efficacy of oral Beta blockade before computed tomographic coronary angiography显示文摘 | DE GRAAF FR SCHUIJF JD VAN VELZEN JE | 2010 | Am J Cardiol2010，105，： | 1 |
| 18 | Different glucocorticoids vary in their genomic and non-genomic mechanism of action in A549 cells显示文摘 | Croxtall JD van Hal PT Choudhury Q | 2002 | Br J Pharmacol2002，135，2： | 1 |
| 19 | International staging system and metaphase cytogenetic abnormalities in the era of gene expression profiling data in multiple myeloma treated with total therapy 2 and 3 protocols 显示文摘 | Waheed S Shaughnessy JD van Rhee F | 2011 | Cancer2011，117，5： | 1 |
| 20 | The burden and determinants of neck pain in workers:results of the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders显示文摘 | Cote P Van DV Cassidy JD | 2009 | J Manipulative Physiol Ther2009，32，： | 1 |
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