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| 1 | Improving the outcomes in oncological colorectal surgery显示文摘During the last several decades,colorectal cancer surgery has experienced some major perioperative improvements.Preoperative risk-assessment of nutrition,frailty,and sarcopenia followed by interventions for patient optimization or an adapted surgical strategy,contributed to improved postoperative outcomes.Enhanced recovery programs or fast-track surgery also resulted in reduced length of hospital stay and overall complications without affecting patient safety.After an initially indecisive start due to uncertainty about oncological safety,the most significant improvement in intraoperative care was the introduction of laparoscopy.Laparoscopic surgery for colon and rectal cancer is associated with better short-term outcomes,whereas long-term outcomes regarding survival and recurrence rates are comparable.Nevertheless,long-term results in rectal surgery remain to be seen.Early recognition of anastomotic leakage remains a challenge,though multiple improvements have allowed better management of this complication. | Jeroen LA van Vugt Kostan W Reisinger Joep PM Derikx Djamila Boerma Jan HMB Stoot | 2014 | World Journal of Gastroenterology2014，20，35： | 13 |
| 2 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 3 | International R&D spillovers: A comment显示文摘 | Frank R Lichtenberg Bruno van Pottelsberghe de la Potterie | 1998 | European Economic Review1998，，8： | 3 |
| 4 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | The Lancet . 2005 (9454)2005，，： | 2 |
| 5 | The internationalisation of technology analysed with patent data显示文摘 | Dominique Guellec Bruno van Pottelsberghe de la Potterie | 2001 | Research Policy2001，，8： | 2 |
| 6 | Does Foreign Direct Investment Transfer Technology Across Borders?显示文摘 | Bruno van Pottelsberghe de la Potterie Frank Lichtenberg | 2001 | Review of Economics and Statistics2001，，： | 2 |
| 7 | The tolerance of rat spinal cord to interstitial irradiation显示文摘 | Van der plas M Ruifork AC | 1998 | Int J Radiat Oncol Biol Phys1998，40，： | 1 |
| 8 | Flavonoid genes in pentunia:addition of a limited number of gene copies may lead to a suppression of gene expression显示文摘 | Mur LA Beld M | 1990 | Plant Cell1990，2，： | 1 |
| 9 | Claiming more: The increased voluminosity of patent applications and its determinants 显示文摘 | Van Zeebroeck N van Pottelsberghe de la Potterie B Guellec D | 2009 | Research Policy2009，38，6： | 1 |
| 10 | Regulatory role of p27kip1 in the mouse and human testis显示文摘 | Beumer TL Kiyokawa H Roepers-Gajadien HL van den Bos LA Lock TM Gademan IS Rutgers DH Koff A de Rooij DG | | 0，，： | 1 |
| 11 | Cytomegalovirus as a cause of anterior uveitis in immunocompetent patients显示文摘 | van Boxtel LA van der Lelij A van der Meer J | 2007 | Ophthalmology2007，114，： | 1 |
| 12 | Prognos- tic value of galectin-3, a novel marker of fibrosis, in pa- tients with chronic heart failure:data from the DEAL-HF study显示文摘 | Lok DJ Van Der Meer P de la Porte PW | 2010 | Clin Res Cardiol2010，99，5： | 1 |
| 13 | Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish显示文摘 | Timme -Laragy AR Van Tiem LA Linney EA | 2009 | Toxicol Sci2009，109，2： | 1 |
| 14 | Fine-tuning of the piping model through small-scale,medium-scale and ijkdijk experiments 显示文摘 | SELLMEIJER J B LOPEZ de LA CRUZ J van BEEK V M KNOEFF J G | 2011 | European Journal of Environmental and Civil Engineering2011，15，8： | 1 |
| 15 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | 2005 (9454)2005，，9454： | 1 |
| 16 | Simultaneous nitrification/ denitrification in aerobic chemostat cultures of thiosphaera 显示文摘 | Robertson LA Van Niel EWJ Torremans RAM | 1988 | Applied and Environmental Microbiology1988，54，11： | 1 |
| 17 | Defining community acquired pneumonia severity on presentation to hospital:an international derivation and validation study显示文摘 | Lim WS van der Eerden MM Laing R | 2003 | Thorax2003，58，5： | 1 |
| 18 | Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-Tetrahydro-4-n-propyl-2H,5H- benzopyrano-1,4-oxazin-9-ol (PD 128907)显示文摘 | VAN VLIET LA RODENHUIS N DIJKSTRA D | 2000 | JMed Chem2000，43，15： | 1 |
| 19 | Evaluati- on of tests of central nervous system performance after hy- poxemia for a model for cognitive impairment显示文摘 | van der Post J Noordzij LA de Kam ML | 2002 | J Psy- chopharmacol2002，16，4： | 1 |
| 20 | From R&D to Productivity Growth: Do the Institutional Set- tings and the Source of Funds of R&D Matter显示文摘 | Guellec D van Pottelsberghe de la Potterie B | 2004 | Oxford Bulletin of Economics and Statistics2004，66，3： | 1 |
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