|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 3 | Interaction between cisplatin and gemcitabine in vitro and in vivo 显示文摘 | Peters G J Bergman A M Ruiz van Haperen V W | 1995 | Semin Oncol1995，22，411： | 1 |
| 4 | The relation between morphology and hydrotreating activity for supported MoS2 particles 显示文摘 | HENSEN E J M KOOYMAN P J Van der MEER Y Van der KRAAN A M de BEER V H J Van VEEN J A R Van SANTEN R A | 2001 | J Catal2001，199，2： | 1 |
| 5 | Errons and margins in radiotherapy显示文摘 | Van Herk M Remeijer P Lebesque J V | 2004 | Semin Radiat Oncol2004，14，1： | 1 |
| 6 | A combination of anti-CD3 and anti-CD7 ricin A-immunotoxins for the in vivo treatment of acute graft versus host disease 显示文摘 | Liesbeth van Emst Anton V M B Schattenberg | 2000 | Blood2000，95，12： | 1 |
| 7 | The effect of CYP3A5 and MDR1(ABCB1)polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients显示文摘 | Haufroid V Mourad M Van Kerckhove V | 2004 | Pharmacogenetics2004，14，3： | 1 |
| 8 | The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders显示文摘 | van der Stelt M Di Marzo V | 2003 | Eur J Pharmacol2003，480，1： | 1 |
| 9 | Randomized phase II comparison of dose-intense gem-citabine:thirty-minute infusion and fixed dose rate in-fusion in patients with pancreatic adenocarcinoma显示文摘 | Tempero M Plunkett W Ruiz Van Haperen V | 2003 | JClin Oncol2003，21，34： | 1 |
| 10 | Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitisB using HBsAg and HBV DNA levels 显示文摘 | Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL | 2010 | Hepatology2010，52，2： | 1 |
| 11 | Process mining for ubiquitous mobile systems: an overview and a concrete algorithm 显示文摘 | Ana K A d M Boudewijn F van D Wil M P v d A | 2004 | Ubiquitous Mobile Information and Collaboration Systems2004，3272，1： | 1 |
| 12 | Supply chain management in food chains:Im proving performance by reducing uncertainty显示文摘 | VAN D V BEULENS A J M WIT W D | 1998 | International Transactions in Operational Research1998，5，6： | 1 |
| 13 | Globai estimates of ambient fine particulate matter concentrations from satellite-based aerosol optical depth: Development and application显示文摘 | VAN DONKELAAR A MARTIN R V BRAUER M | 2010 | Environ Health Perspectives2010，118，6： | 1 |
| 14 | Fine-tuning of the piping model through small-scale,medium-scale and ijkdijk experiments 显示文摘 | SELLMEIJER J B LOPEZ de LA CRUZ J van BEEK V M KNOEFF J G | 2011 | European Journal of Environmental and Civil Engineering2011，15，8： | 1 |
| 15 | SIRT6 overexpression induces massive apoptosis in cancer cells but not in norm~ cells 显示文摘 | Van Meter M Mao Z Gorbunova V | 2011 | Cell Cycle2011，10，18： | 1 |
| 16 | Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson’s disease(NSTAPS study):a randomised controlled trial显示文摘 | Odekerken V J van Laar T Staal M J | 2013 | Lancet Neurol2013，12，1： | 1 |
| 17 | Errors and margins in radiotherapy 显示文摘 | VAN HERK M REMEIJER P LEBESQUE J V | 2004 | Semin Radiat Oncol2004，14，1： | 1 |
| 18 | Convergence Rates in Empirical Bayes Two-action Problems: Ⅱ Continuous Case显示文摘 | John M V Van Ryzin J | 1972 | Ann Math Statist1972，43，： | 1 |
| 19 | Synergistic interaction between ciaplatin and gemcitabine in vitro 显示文摘 | Bergman A M Ruiz van Haperen V W Veerman G | 1996 | Clin Cancer Res1996，2，3： | 1 |
| 20 | Wood forma- tion in poplar : identification, characterization, and seasonal variation of xylem proteins 显示文摘 | Mijnsbrugge K V Meyermans H Van Montagu M | 2000 | Planta2000，210，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员