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| 1 | 自我血压监测对轻中度高血压患者治疗依从性的影响显示文摘 | 张玲玉 叶鹏 van Onzenoort HA Verberk WJ Kroon AA | 2010 | 中华高血压杂志2010，18，8： | 5 |
| 2 | Aspirin responsive platelet thrombophilia in essential thrombocythemia and polycythemia vera显示文摘Essential thrombocythemia(ET) and polycythemia vera(PV) frequently present with erythromelalgia and acrocyanotic complications, migraine-like microvascular cerebral and ocular transient ischemic attacks(MIAs) and/or acute coronary disease. The spectrum of MIAs in ET range from poorly localized symptoms of transient unsteadiness, dysarthria and scintillating scotoma to focal symptoms of transient monocular blindness, transient mono- or hemiparesis or both. The attacks all have a sudden onset, occur sequentially rather than simultaneously, last for a few seconds to several minutes and are usually associated with a dull, pulsatile or migraine-like headache. Increased hematocrit and blood viscosity in PV patients aggravate the microvascular ischemic syndrome of thrombocythemia to major arterial and venous thrombotic complications. Phlebotomy to correct hematocrit to normal in PV significantly reduces major arterial and venous thrombotic complications, but fails to prevent the platelet-mediated erythromelalgia and MIAs. Complete long-term relief of the erythromelalgic microvascular disturbances, MIAs and major thrombosis in ET and PV patients can be obtained with low dose aspirin and platelet reduction to normal, but not with anticoagulation. Skin punch biopsies from the erythromelalgic area show fibromuscular intimal proliferation of arterioles complicated by occlusive plateletrich thrombi leading to acrocyanotic ischemia. Symptomatic ET patients with erythromelalgic microvascular disturbances have shortened platelet survival, increased platelet activation markers β-thromboglobulin(β-TG), platelet factor 4(PF4) and thrombomoduline(TM), increased urinary thromboxane B2(TXB2) excretion, and no activation of the coagulation markers thrombin fragments F1+2 and fibrin degradation products. Inhibition of platelet cyclooxygenase(COX1) by aspirin is followed by the disappearance and no recurrence of microvascular disturbances, increase in platelet number, correction of the shortened platelet survival times to normal, and reduction of increased plasma levels of β-TG, PF4, TM and urinary TXB2 excretion to normal. These results indicate that platelet-mediated fibromuscular intimal proliferation and platelet-rich thrombi in the peripheral, cerebral and coronary end-arterial microvasculature are responsible for the erythromelalgic ischemic complica-tions, MIAs and splanchnic vein thrombosis. Baseline platelet P-selectin levels and arachidonic acid induced COX1 mediated platelet activation showed a highly significant increase of platelet P-selectin expression(not seen in ADP and collagen stimulated platelets), which was significantly higher in JAK2V617 F mutated compared to JAK2 wild type ET. | Jan Jacques Michiels Fibo WJ Ten Kate Peter J Koudstaal Perry JJ Van Genderen | 2013 | World Journal of Hematology2013，2，2： | 4 |
| 3 | A new selfexpandable nitinol stem for the treatment of wide-neck aneurysms:initial clinical experience显示文摘 | Peluso JP Van Rooij WJ Sluzewski M | 2008 | AJNR2008，29，： | 1 |
| 4 | Cell transplantation for cardiac regenerarion:where do we stand? 显示文摘 | van den Bos E J van der Giessen WJ Duncker DJ | 2008 | Neth Heart J2008，16，3： | 1 |
| 5 | Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway显示文摘 | de Jonge WJ van der Zanden EP The FO | 2005 | Nat Immunol2005，6，8： | 1 |
| 6 | Presence of enteric viruses in source waters for drinking water production in The Netherlands 显示文摘 | Lodder WJ van den Berg HH Rutjes SA | 2010 | Appl Environ Microbiol2010，76，17： | 1 |
| 7 | Multifunctional drugs with different CNS targets for neuropsychiatric disorders显示文摘 | Van der Schyf CJ Geldenhuys WJ Youdim MB | 2006 | J Neurochem2006，99，4： | 1 |
| 8 | The role of lesional T cells in recalcitrant psoriasis during infliximab therapy显示文摘 | Bovenschen HJ Van De KerkhofPC Gerritsen WJ | | 0，，06： | 1 |
| 9 | No local recurrence of enchondroma after curettage and plaster filling 显示文摘 | Gaasbeek RD Rijnberg WJ van Loon CJ | 2005 | Arch Orthop Trauma Surg2005，1，： | 1 |
| 10 | A concise review of DNA damage checkpoints and repair in mammalian ceils 显示文摘 | Houtpraaf JH Versmissen J van der Giessen WJ | 2006 | Cardiovasc Revasc Med2006，7，3： | 1 |
| 11 | Cardiovascular risk assessment of the diabetic patient undergoing major noncardiac surgery显示文摘 | Hoeks S Flu WJ Van Kuijk JP | | Best Practice & Reserch Clinical Endocrinology & Metabolism0，，： | 1 |
| 12 | Similar effects of rofecoxib and indomethacin on the incidence of heterotopic ossification after hip arthroplasty 显示文摘 | van der Heide HJ Rijnberg WJ Van Sorge A | 2007 | Acta Orthop2007，78，1： | 1 |
| 13 | A concise review of DNA damage checkpoints and repair in mammalian cells显示文摘 | HOUTGRAAF JH VERSMISSEN J VAN DER GIESSEN WJ | 2006 | CardioRevasc Med2006，7，3： | 1 |
| 14 | Coiling of in- tracranial aneurysms: a systematic review on initial occlusion and reopening and treatment rates 显示文摘 | Ferns SP Sprenqers ME Van Rooij WJ | 2009 | Stroke2009，40，： | 1 |
| 15 | Relation between aneurysm volume, packing, and compaction in 145 cerebral aneurysms treated with coils 显示文摘 | Sluzewski M van Rooij WJ Slob M J | 2004 | Radiology2004，231，： | 1 |
| 16 | Endovascular treatment of ruptured intracranial aneurysms with detachable coils:long-term clinical and serial angiographic results 显示文摘 | Sluzewski M van Rooij WJ Rinkel GJ | 2003 | Radiology2003，227，3： | 1 |
| 17 | Mini extracorporeal circuit for coronary artery bypass gratring:initial clinical and biochemical results显示文摘 | Van Boven WJ Gerritsen WB Waanders FG | 2004 | Perfusion2004，19，： | 1 |
| 18 | Prenatal diagnosis of citrullinemia and argininosuecinic aciduria:evidence for a transmission ratio distortion in citrullinemia显示文摘 | Kleijer WJ Carritsen VH van der Sterre ML | 2006 | Prenat Diagn2006，26，3： | 1 |
| 19 | Sensory gating of auditory evoked potentials in rats:effects of repetitive stimulation and the interstimulus interval显示文摘 | De Bruin NM Ellenbroek BA Van Schaijk WJ | 2001 | Biological Psychology2001，55，： | 1 |
| 20 | Ribosome -inactivating proteins from plants: more than RNA N- glycosidases? 显示文摘 | Peumans WJ Hao Q Van Damme EJM | 2001 | The FASEB Journal2001，15，： | 1 |
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