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| 1 | MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines显示文摘AIM:To investigate expression of microRNA(miRNA)and potential targets in chemotherapy resistant esoph-ageal cancer cell lines.METHODS:An in-vitro model of acquired chemotherapy resistance in esophageal adeno-(EAC)and squamous cell carcinoma(ESCC)cells was used,and microRNA expression profiles for cisplatin or 5-fluorouracil(5-FU)resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction(PCR).The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.RESULTS:Chemotherapy resistant sublines were found to have specific miRNA signatures,and these miRNA signatures were different for the cisplatin vs 5-FU resistant cells from the same tumor cell line,and also for EAC vs ESCC cells with resistance to the same specific chemotherapy agent.Amongst others,miR-27b-3p,miR-193b-3p,miR-192-5p,miR-378 a-3p,miR-125a-5p and miR-18a-3p were dysregulated,consistent with negative posttranscriptional control of KRAS,TYMS,ABCC3,CBL-B and ERBB2 expression via these miRNAs.CONCLUSION:The current study supports the hypothesis that microRNA expression has an impact on chemotherapy resistance in esophageal cancer. | Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek Joerg Haier Damian J Hussey | 2014 | World Journal of Gastroenterology2014，20，40： | 8 |
| 2 | Industrial ecology framework for achieving cleaner production in the mining and minerals industry 显示文摘 | Arun J B Dirk J A van Z | 2006 | Journal of Cleaner Production2006，，34： | 1 |
| 3 | Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins显示文摘 | van der Velden J Papp Z Zaremba R | 2003 | Cardiovasc Res2003，57，1： | 1 |
| 4 | Farfield impact of water injection dredging in the Crouch River 显示文摘 | Winterwerp J C Wang Z B Kester J A Th M van | 2002 | Water & maritime engineering2002，，4： | 1 |
| 5 | The influence of top management team's corporate governance orientation on strategic renewal trajectories 显示文摘 | Kwee Z Van den Bosch F A J Volberda H W | 2011 | Journal of Management Studies2011，48，5： | 1 |
| 6 | Simian rotaviruses possess divergent gene constellations that originated from interspecies transmission and reas- sortment 显示文摘 | Matthijnssens J Taraporewala Z F Yang H Rao S Yuan L Cao D Hoshino Y Mertens P P Carner G R McNeal M Sestak K Van Ranst M Patton J T | 2010 | J Virol2010，84，4： | 1 |
| 7 | Cavitation, primary break-up and flash boiling of gaso- line, iso-octane and n-pentane with a real-size optical di- rect-injection nozzle 显示文摘 | Serras-Pereira J Van Romunde Z Aleiferis P G | 2010 | Fuel2010，89，9： | 1 |
| 8 | DNA phylogeny,morphology and pathogenicity of Botryosphaeria species on grapevines 显示文摘 | Van Niekerk J M Crous P W Groenewald J Z | 2004 | Mycologia2004，96，4： | 1 |
| 9 | Prevalence of vaeuolating eytotoxin production and distribution of Distint vaA alleles in Helieobaeter pylori from China 显示文摘 | Pan Z J Berg D E van Hulst D | 1998 | J Infeet Dis1998，178，1： | 1 |
| 10 | DNA phylogeny, morphology and pathogenicity of Botryosphaeria species on grapevines显示文摘 | Van Niekerk J M Crous P W Groenewald J Z | 2004 | Mycologia2004，96，4： | 1 |
| 11 | Consumer attitudes, knowledge, and consumption of organic yogurt显示文摘 | VAN LOO E J DIEM M N H PIENIAK Z | 2013 | Journal of Dairy Science2013，96，4： | 1 |
| 12 | Equally high prevalenees of infection with CagA2positive Helicobacter pylori in Chinese patients with peptic ulcer disease and those with chronic gastritis2 associated dyspepsia 显示文摘 | Pan Z J van den Hulst RWM Feller M | 1997 | J Clin Microbiol1997，35，： | 1 |
| 13 | Three- year outcome of sirolimus-eluting versus bare-metal stents for the treatment of ST-segment elevation myocardial infarction from the MISSION Intervention Study) 显示文摘 | ATARY J Z van der HOEVEN B L LIEM S S | 2010 | Am J Cardiol2010，106，1： | 1 |
| 14 | A comprehensive platform for quality control of botanical drugs (PhytomicsQC):a case study of Huangqin Tang (HQT) and PHY906显示文摘 | Tilton R Paiva A A Guan J Q Marathe R Jiang Z van Eyndhoven W Bjoraker J Prusoff Z Wang H Liu S H Cheng Y C | | 0，，30： | 1 |
| 15 | Crystal morphology engineering by 'tailor-made' inhibitors: A new probe to fine intermolecular interactions显示文摘 | Berkovitch-Yellin Z van Mil J Addadi L | 1985 | J Am Chem Soc1985，107，11： | 1 |
| 16 | Role of quinones in the biodegradation of priority pollutants, A review 显示文摘 | FISLD J A CERVANTES F J VAN der Z F P | 2000 | Water Sci Technol2000，42，： | 1 |
| 17 | Changes in grain size of sand in transport over foredune 显示文摘 | Arens S M Van Boxel J H Abuodha J O Z | 2002 | Earth Sur(ace Process and Landforms2002，27，： | 1 |
| 18 | Metabolic model for glycogen accumulating organisms in anaerobic/aerobic activated sludge systems显示文摘 | Zeng R J van Loosdrecht M C M Yuan Z G | 2003 | Biotechnol Bioeng2003，81，1： | 1 |
| 19 | Microbial gene functions enriched in the Deepwater Horizon deep-sea oil plume显示文摘 | Lu Z Deng Y Van Nostrand J D | 2011 | The ISME journal2011，6，2： | 1 |
| 20 | Cardiomyocyte stiffness in diastolic heart failure显示文摘 | BORBELY A VAN DER VELDEN J PAPP Z | 2005 | Circulation2005，111，： | 1 |
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